scholarly journals Correction to “Selective Recognition of Highly Hydrophilic Molecules in Water by Endo-Functionalized Molecular Tubes”

2020 ◽  
Vol 142 (11) ◽  
pp. 5446-5446
Author(s):  
Guo-Bao Huang ◽  
Sheng-Hua Wang ◽  
Hua Ke ◽  
Liu-Pan Yang ◽  
Wei Jiang
Keyword(s):  
Selective Recognition ◽  
Molecular Tubes

Selective Recognition of Highly Hydrophilic Molecules in Water by Endo-Functionalized Molecular Tubes

2016 ◽  
Vol 138 (44) ◽  
pp. 14550-14553 ◽  
Author(s):  
Guo-Bao Huang ◽  
Sheng-Hua Wang ◽  
Hua Ke ◽  
Liu-Pan Yang ◽  
Wei Jiang
Keyword(s):  
Selective Recognition ◽  
Molecular Tubes

scholarly journals Selective recognition of aromatic hydrocarbons by endo-functionalized molecular tubes via C/N-H⋅⋅⋅ π interactions

2018 ◽  
Vol 29 (1) ◽  
pp. 91-94 ◽  
Author(s):  
Guo-Bao Huang ◽  
Wei-Er Liu ◽  
Arto Valkonen ◽  
Huan Yao ◽  
Kari Rissanen ◽  
...  
Keyword(s):  
Aromatic Hydrocarbons ◽  
Selective Recognition ◽  
Π Interactions ◽  
Molecular Tubes

scholarly journals Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 106
Author(s):  
Joana N. Martins ◽  
João Carlos Lima ◽  
Nuno Basílio
Keyword(s):  
Amino Acids ◽  
Selective Recognition ◽  
Great Promise ◽  
Macrocyclic Compounds ◽  
Synthetic Receptors ◽  
Small Peptides ◽  
Molecular Imprinted Polymers ◽  
Polymeric Systems ◽  
Physiological Conditions ◽  
Level Information

To this day, the recognition and high affinity binding of biomolecules in water by synthetic receptors remains challenging, while the necessity for systems for their sensing, transport and modulation persists. This problematic is prevalent for the recognition of peptides, which not only have key roles in many biochemical pathways, as well as having pharmacological and biotechnological applications, but also frequently serve as models for the study of proteins. Taking inspiration in nature and on the interactions that occur between several receptors and peptide sequences, many researchers have developed and applied a variety of different synthetic receptors, as is the case of macrocyclic compounds, molecular imprinted polymers, organometallic cages, among others, to bind amino acids, small peptides and proteins. In this critical review, we present and discuss selected examples of synthetic receptors for amino acids and peptides, with a greater focus on supramolecular receptors, which show great promise for the selective recognition of these biomolecules in physiological conditions. We decided to focus preferentially on small synthetic receptors (leaving out of this review high molecular weight polymeric systems) for which more detailed and accurate molecular level information regarding the main structural and thermodynamic features of the receptor biomolecule assemblies is available.

scholarly journals Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xuesong Wang ◽  
Willem Jespers ◽  
Rubén Prieto-Díaz ◽  
Maria Majellaro ◽  
Adriaan P. IJzerman ◽  
...  
Keyword(s):  
Radioligand Binding ◽  
Structural Data ◽  
Binding Mode ◽  
Selective Recognition ◽  
Chiral Hplc ◽  
Binding Assays ◽  
Structural Determinants ◽  
X Ray Crystallography ◽  
Adenosine Receptor Antagonist ◽  
Energy Perturbation

AbstractThe four adenosine receptors (ARs) A1AR, A2AAR, A2BAR, and A3AR are G protein-coupled receptors (GPCRs) for which an exceptional amount of experimental and structural data is available. Still, limited success has been achieved in getting new chemical modulators on the market. As such, there is a clear interest in the design of novel selective chemical entities for this family of receptors. In this work, we investigate the selective recognition of ISAM-140, a recently reported A2BAR reference antagonist. A combination of semipreparative chiral HPLC, circular dichroism and X-ray crystallography was used to separate and unequivocally assign the configuration of each enantiomer. Subsequently affinity evaluation for both A2A and A2B receptors demonstrate the stereospecific and selective recognition of (S)-ISAM140 to the A2BAR. The molecular modeling suggested that the structural determinants of this selectivity profile would be residue V2506.51 in A2BAR, which is a leucine in all other ARs including the closely related A2AAR. This was herein confirmed by radioligand binding assays and rigorous free energy perturbation (FEP) calculations performed on the L249V6.51 mutant A2AAR receptor. Taken together, this study provides further insights in the binding mode of these A2BAR antagonists, paving the way for future ligand optimization.

Bowl-like mesoporous polydopamine with size exclusion for highly selective recognition of endogenous glycopeptides

Talanta ◽  
2021 ◽  
pp. 122468
Author(s):  
Yuyan Yan ◽  
Renlu Han ◽  
Yafei Hou ◽  
Huijun Zhang ◽  
Jiancheng Yu ◽  
...  
Keyword(s):  
Size Exclusion ◽  
Selective Recognition

Synthesis of polyethylene glycol functional bonded silica gel for selective recognition and separation of α-cyclodextrin

2021 ◽  
Vol 1639 ◽  
pp. 461917
Author(s):  
Xinying Zheng ◽  
Yang Qin ◽  
Xiaobing Meng ◽  
Zhengyu Jin ◽  
Liuping Fan ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Silica Gel ◽  
Selective Recognition

scholarly journals Correction: Selective recognition of DNA defects by cyclometalated Ir(iii) complexes

2021 ◽  
Author(s):  
David Paul Elisa Dayanidhi ◽  
Rosaria Pinky Malapati ◽  
Vaidyanathan Vaidyanathan Ganesan
Keyword(s):  
Selective Recognition ◽  
Dalton Trans

Correction for ‘Selective recognition of DNA defects by cyclometalated Ir(iii) complexes’ by David Paul Elisa Dayanidhi et al., Dalton Trans., 2019, 48, 13536–13540, DOI: 10.1039/C9DT01225G.

Multilevel/hierarchical nanocomposite imprinted regenerated cellulose membranes for high-efficiency separation: A selective recognition method with Au/PDA-loaded surface

2021 ◽  
Author(s):  
Ming Yan ◽  
Yilin Wu ◽  
Rongxin Lin ◽  
Faguang Ma ◽  
Zhongyi Jiang
Keyword(s):  
Molecular Imprinting ◽  
High Efficiency ◽  
Selective Separation ◽  
Selective Recognition ◽  
Regenerated Cellulose ◽  
Separation Performance ◽  
Recognition Method ◽  
Membrane Materials ◽  
Loaded Surface ◽  
Cellulose Membranes

Although many researchers have done lots of studies on improving the selective separation performance of membrane materials, conceptions and applications of membrane-based molecular imprinting separation&recognition with both high permselectivity and...

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