scholarly journals Multiple Mechanisms Mapped in Aryl Alkyl Ether Cleavage via Aqueous Electrocatalytic Hydrogenation over Skeletal Nickel

2020 ◽  
Vol 142 (8) ◽  
pp. 4037-4050 ◽  
Author(s):  
Yuting Zhou ◽  
Grace E. Klinger ◽  
Eric L. Hegg ◽  
Christopher M. Saffron ◽  
James E. Jackson
Keyword(s):  
Alkyl Ether ◽  
Electrocatalytic Hydrogenation ◽  
Ether Cleavage ◽  
Skeletal Nickel

LAH Aryl Alkyl Ether Cleavage of BINOL Derivatives.

ChemInform ◽  
2005 ◽  
Vol 36 (18) ◽  
Author(s):  
Walter E. Kowtoniuk ◽  
Darren K. MacFarland
Keyword(s):  
Alkyl Ether ◽  
Ether Cleavage

Selective alkyl ether cleavage by cationic bis(phosphine)iridium complexes

2019 ◽  
Vol 17 (7) ◽  
pp. 1744-1748 ◽  
Author(s):  
Caleb A. H. Jones ◽  
Nathan D. Schley
Keyword(s):  
Functional Groups ◽  
Alkyl Ether ◽  
Iridium Complexes ◽  
Ether Cleavage ◽  
Mild Conditions

Simple cationic bis(phosphine)iridium complexes are shown to be highly selective catalysts for ether cleavage with silanes. Benzylic ethers can be cleaved under mild conditions in the presence of reductively-labile functional groups.

LAH aryl alkyl ether cleavage of BINOL derivatives

2005 ◽  
Vol 46 (3) ◽  
pp. 451-453 ◽  
Author(s):  
Walter E. Kowtoniuk ◽  
Darren K. MacFarland
Keyword(s):  
Alkyl Ether ◽  
Ether Cleavage

Electrocatalytic hydrogenation of alkenes on LaNi5 electrodes

2000 ◽  
Vol 487 (1) ◽  
pp. 31-36 ◽  
Author(s):  
G.M.R van Druten ◽  
E Labbé ◽  
V Paul-Boncour ◽  
J Périchon ◽  
A Percheron-Guégan
Keyword(s):  
Electrocatalytic Hydrogenation

Boron insertion into alkyl ether bonds via zinc/nickel tandem catalysis

Science ◽  
2021 ◽  
Vol 372 (6538) ◽  
pp. 175-182
Author(s):  
Hairong Lyu ◽  
Ilia Kevlishvili ◽  
Xuan Yu ◽  
Peng Liu ◽  
Guangbin Dong
Keyword(s):  
Nickel Catalyst ◽  
Bioactive Compounds ◽  
Cyclic Ethers ◽  
Alkyl Ether ◽  
Tandem Catalysis ◽  
Mechanistic Studies ◽  
Alkyl Ethers ◽  
Nitrogen Substitution ◽  
Zinc Nickel

Mild methods to cleave the carbon-oxygen (C−O) bond in alkyl ethers could simplify chemical syntheses through the elaboration of these robust, readily available precursors. Here we report that dibromoboranes react with alkyl ethers in the presence of a nickel catalyst and zinc reductant to insert boron into the C−O bond. Subsequent reactivity can effect oxygen-to-nitrogen substitution or one-carbon homologation of cyclic ethers and more broadly streamline preparation of bioactive compounds. Mechanistic studies reveal a cleavage-then-rebound pathway via zinc/nickel tandem catalysis.

scholarly journals Synthetic Alkyl-Ether-lipid promotes TRPV2 Channel trafficking trough PI3K/Akt-Girdin Axis in cancer cells and increases mammary tumor volume

Cell Calcium ◽  
2021 ◽  
pp. 102435
Author(s):  
Maxime Guéguinou ◽  
Romain Felix ◽  
Séverine Marionneau-Lambot ◽  
Thibault Oullier ◽  
Aubin Penna ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mammary Tumor ◽  
Tumor Volume ◽  
Ether Lipid ◽  
Alkyl Ether ◽  
Channel Trafficking

scholarly journals Synthesis of Valeric Acid by Selective Electrocatalytic Hydrogenation of Biomass-Derived Levulinic Acid

Catalysts ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 692
Author(s):  
Yan Du ◽  
Xiao Chen ◽  
Ji Qi ◽  
Pan Wang ◽  
Changhai Liang
Keyword(s):  
Levulinic Acid ◽  
Active Sites ◽  
Valeric Acid ◽  
Future Research ◽  
Adsorbed Hydrogen ◽  
Electrocatalytic Hydrogenation ◽  
Ambient Conditions ◽  
Metallic Lead ◽  
Faradaic Efficiency ◽  
Lead Electrode

The electrocatalytic hydrogenation (ECH) of biomass-derived levulinic acid (LA) is a promising strategy to synthetize fine chemicals under ambient conditions by replacing the thermocatalytic hydrogenation at high temperature and high pressure. Herein, various metallic electrodes were investigated in the ECH of LA in a H-type divided cell. The effects of potential, electrolyte concentration, reactant concentration, and temperature on catalytic performance and Faradaic efficiency were systematically explored. The high conversion of LA (93%) and excellent “apparent” selectivity to valeric acid (VA) (94%) with a Faradaic efficiency of 46% can be achieved over a metallic lead electrode in 0.5 M H2SO4 electrolyte containing 0.2 M LA at an applied voltage of −1.8 V (vs. Ag/AgCl) for 4 h. The combination of adsorbed LA and adsorbed hydrogen (Hads) on the surface of the metallic lead electrode is key to the formation of VA. Interestingly, the reaction performance did not change significantly after eight cycles, while the surface of the metallic lead cathode became rough, which may expose more active sites for the ECH of LA to VA. However, there was some degree of corrosion for the metallic lead cathode in this strong acid environment. Therefore, it is necessary to improve the leaching-resistance of the cathode for the ECH of LA in future research.

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