Theoretical Studies of Fundamental Pathways for Alkaline Hydrolysis of Carboxylic Acid Esters in Gas Phase

2000 ◽  
Vol 122 (7) ◽  
pp. 1522-1530 ◽  
Author(s):  
Chang-Guo Zhan ◽  
Donald W. Landry ◽  
Rick L. Ornstein
1958 ◽  
Vol 12 ◽  
pp. 1492-1506 ◽  
Author(s):  
Edith Heilbronn ◽  
William Taub ◽  
David Ginsburg ◽  
K. Hartiala ◽  
S. Veige ◽  
...  

1971 ◽  
Vol 49 (17) ◽  
pp. 2797-2802 ◽  
Author(s):  
D. E. Horning ◽  
G. Lacasse ◽  
J. M. Muchowski

The sulfuric acid catalyzed acylation of 2-methyl-5-nitroisocarbostyril with carboxylic acid anhydrides gave the corresponding 4-acylated derivatives 3, which underwent reductive cyclization to 2-substituted derivatives of 4-methyl-1,3,4,5-tetrahydropyrrolo[4.3.2.de]isoquinolin-5-one (4). Alkaline hydrolysis of the six-membered lactam in 4 was accompanied by a retro-Mannich reaction to produce 2-substituted indole-4-carboxylic acids in about 40 % overall yield from 3.


2003 ◽  
Vol 24 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Jiaqing Xie ◽  
Yi Zhang ◽  
Juan Du ◽  
Xian‐cheng Zeng ◽  
Ying‐jin Liu ◽  
...  

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