Chemical Simulation of Biogenesis of the 2,4,5-Trihydroxyphenylalanine Quinone Cofactor of Copper Amine Oxidases:  Mechanistic Distinctions Point toward a Unique Role of the Active Site in theo-Quinone Water Addition Step†

2000 ◽  
Vol 122 (15) ◽  
pp. 3574-3584 ◽  
Author(s):  
Subrata Mandal ◽  
Younghee Lee ◽  
Matthew M. Purdy ◽  
Lawrence M. Sayre
Keyword(s):  
Active Site ◽  
Amine Oxidases ◽  
Water Addition ◽  
Unique Role ◽  
Chemical Simulation ◽  
Trihydroxyphenylalanine Quinone ◽  
Copper Amine Oxidases ◽  
Copper Amine

ChemInform Abstract: The Reductive and Oxidative Half-Reactions and the Role of Copper Ions in Plant and Mammalian Copper-Amine Oxidases.

ChemInform ◽  
2001 ◽  
Vol 32 (11) ◽  
pp. no-no
Author(s):  
Alessandra Padiglia ◽  
Rosaria Medda ◽  
Andrea Bellelli ◽  
Enzo Agostinelli ◽  
Laura Morpurgo ◽  
...  
Keyword(s):  
Copper Ions ◽  
Amine Oxidases ◽  
Copper Amine Oxidases ◽  
Copper Amine

scholarly journals Unique protonation states of aspartate and topaquinone in the active site of copper amine oxidase

RSC Advances ◽  
2020 ◽  
Vol 10 (63) ◽  
pp. 38631-38639
Author(s):  
Mitsuo Shoji ◽  
Takeshi Murakawa ◽  
Mauro Boero ◽  
Yasuteru Shigeta ◽  
Hideyuki Hayashi ◽  
...  
Keyword(s):  
Biogenic Amines ◽  
Active Site ◽  
Amine Oxidase ◽  
First Principle ◽  
Amine Oxidases ◽  
Oxidative Deamination ◽  
Copper Amine Oxidase ◽  
First Principle Calculations ◽  
Copper Amine Oxidases ◽  
Copper Amine

Copper amine oxidases catalyze the oxidative deamination of biogenic amines. We investigated the unique protonation states in the active site using first-principle calculations.

The Reductive and Oxidative Half-Reactions and the Role of Copper Ions in Plant and Mammalian Copper−Amine Oxidases

2001 ◽  
Vol 2001 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Alessandra Padiglia ◽  
Rosaria Medda ◽  
Andrea Bellelli ◽  
Enzo Agostinelli ◽  
Laura Morpurgo ◽  
...  
Keyword(s):  
Copper Ions ◽  
Amine Oxidases ◽  
Copper Amine Oxidases ◽  
Copper Amine

scholarly journals The Copper Amine Oxidase AtCuAOδ Participates in Abscisic Acid-Induced Stomatal Closure in Arabidopsis

Plants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 183 ◽  
Author(s):  
Ilaria Fraudentali ◽  
Sandip A. Ghuge ◽  
Andrea Carucci ◽  
Paraskevi Tavladoraki ◽  
Riccardo Angelini ◽  
...  
Keyword(s):  
Abscisic Acid ◽  
Amine Oxidase ◽  
Stomatal Closure ◽  
H2o2 Production ◽  
Amine Oxidases ◽  
Wild Type ◽  
Copper Amine Oxidase ◽  
Copper Amine Oxidases ◽  
Copper Amine

Plant copper amine oxidases (CuAOs) are involved in wound healing, defense against pathogens, methyl-jasmonate-induced protoxylem differentiation, and abscisic acid (ABA)-induced stomatal closure. In the present study, we investigated the role of the Arabidopsis thaliana CuAOδ (AtCuAOδ; At4g12290) in the ABA-mediated stomatal closure by genetic and pharmacological approaches. Obtained data show that AtCuAOδ is up-regulated by ABA and that two Atcuaoδ T-DNA insertional mutants are less responsive to this hormone, showing reduced ABA-mediated stomatal closure and H2O2 accumulation in guard cells as compared to the wild-type (WT) plants. Furthermore, CuAO inhibitors, as well as the hydrogen peroxide (H2O2) scavenger N,N1-dimethylthiourea, reversed most of the ABA-induced stomatal closure in WT plants. Consistently, AtCuAOδ over-expressing transgenic plants display a constitutively increased stomatal closure and increased H2O2 production compared to WT plants. Our data suggest that AtCuAOδ is involved in the H2O2 production related to ABA-induced stomatal closure.

scholarly journals Tyrosine codon corresponds to topa quinone at the active site of copper amine oxidases.

1992 ◽  
Vol 267 (12) ◽  
pp. 7979-7982
Author(s):  
D Mu ◽  
S.M. Janes ◽  
A.J. Smith ◽  
D.E. Brown ◽  
D.M. Dooley ◽  
...  
Keyword(s):  
Active Site ◽  
Amine Oxidases ◽  
Topa Quinone ◽  
Copper Amine Oxidases ◽  
Copper Amine

The active site of copper amine oxidases

1984 ◽  
Vol 23 (2-3) ◽  
pp. 325-330 ◽  
Author(s):  
Bruno Mondoví ◽  
Stefania Sabatini ◽  
Olivia Befani
Keyword(s):  
Active Site ◽  
Amine Oxidases ◽  
Copper Amine Oxidases ◽  
Copper Amine
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