Design and Synthesis of a Competent Pyrrolinone−Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1

Amos B. Smith; Andrew B. Benowitz; Paul A. Sprengeler; Joseph Barbosa; Mark C. Guzman; Ralph Hirschmann; Edwin J. Schweiger; David R. Bolin; Zoltan Nagy; Robert M. Campbell; Donald C. Cox; Gary L. Olson

doi:10.1021/ja991251e

Design and Synthesis of a Competent Pyrrolinone−Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1

Journal of the American Chemical Society ◽

10.1021/ja991251e ◽

1999 ◽

Vol 121 (40) ◽

pp. 9286-9298 ◽

Cited By ~ 30

Author(s):

Amos B. Smith ◽

Andrew B. Benowitz ◽

Paul A. Sprengeler ◽

Joseph Barbosa ◽

Mark C. Guzman ◽

...

Keyword(s):

Major Histocompatibility Complex ◽

Class Ii ◽

Major Histocompatibility ◽

Design And Synthesis ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein

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Determinants of the Peptide-induced Conformational Change in the Human Class II Major Histocompatibility Complex Protein HLA-DR1

Journal of Biological Chemistry ◽

10.1074/jbc.275.3.2165 ◽

2000 ◽

Vol 275 (3) ◽

pp. 2165-2173 ◽

Cited By ~ 60

Author(s):

Aaron K. Sato ◽

Jennifer A. Zarutskie ◽

Mia M. Rushe ◽

Aleksey Lomakin ◽

Sateesh K. Natarajan ◽

...

Keyword(s):

Major Histocompatibility Complex ◽

Conformational Change ◽

Class Ii ◽

Major Histocompatibility ◽

Human Class ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein

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Interactions of the human class II major histocompatibility complex protein HLA-DR4 with a peptide ligand demonstrated by affinity capillary electrophoresis

Journal of Chromatography A ◽

10.1016/s0021-9673(97)00487-1 ◽

1997 ◽

Vol 781 (1-2) ◽

pp. 91-97 ◽

Cited By ~ 23

Author(s):

Niels H.H. Heegaard ◽

Bjarke E. Hansen ◽

Arne Svejgaard ◽

Lars H. Fugger

Keyword(s):

Capillary Electrophoresis ◽

Major Histocompatibility Complex ◽

Class Ii ◽

Peptide Ligand ◽

Major Histocompatibility ◽

Human Class ◽

Affinity Capillary Electrophoresis ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein

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Saturation mutagenesis of a major histocompatibility complex protein domain: identification of a single conserved amino acid important for allorecognition.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.85.10.3535 ◽

1988 ◽

Vol 85 (10) ◽

pp. 3535-3539 ◽

Cited By ~ 11

Author(s):

R. Murray ◽

C. A. Hutchison ◽

J. A. Frelinger

Keyword(s):

Major Histocompatibility Complex ◽

Amino Acid ◽

Protein Domain ◽

Saturation Mutagenesis ◽

Major Histocompatibility ◽

Domain Identification ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein

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Positive Selection of TcRalphabeta Thymocytes: Is Cortical Thymic Epithelium an Obligatory Participant in the Presentation of Major Histocompatibility Complex Protein?

Immunological Reviews ◽

10.1111/j.1600-065x.1993.tb00647.x ◽

1993 ◽

Vol 135 (1) ◽

pp. 133-155 ◽

Cited By ~ 29

Author(s):

Patrice Hugo ◽

John W. Kappler ◽

Philippa C. Marrack

Keyword(s):

Major Histocompatibility Complex ◽

Positive Selection ◽

Major Histocompatibility ◽

Thymic Epithelium ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein ◽

Selection Of

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Nonapeptide Analogues Containing (R)-3-Hydroxybutanoate and β-Homoalanine Oligomers: Synthesis and Binding Affinity to a Class I Major Histocompatibility Complex Protein

Journal of Medicinal Chemistry ◽

10.1021/jm981123l ◽

1999 ◽

Vol 42 (13) ◽

pp. 2318-2331 ◽

Cited By ~ 22

Author(s):

Sorana Poenaru ◽

José R. Lamas ◽

Gerd Folkers ◽

José A. López de Castro ◽

Dieter Seebach ◽

...

Keyword(s):

Major Histocompatibility Complex ◽

Binding Affinity ◽

Class I ◽

Major Histocompatibility ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein

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T-cell-mediated association of peptide antigen and major histocompatibility complex protein detected by energy transfer in an evanescent wave-field

Nature ◽

10.1038/320179a0 ◽

1986 ◽

Vol 320 (6058) ◽

pp. 179-181 ◽

Cited By ~ 134

Author(s):

Tania H. Watts ◽

Hermann E. Gaub ◽

Harden M. McConnell

Keyword(s):

Energy Transfer ◽

Major Histocompatibility Complex ◽

T Cell ◽

Wave Field ◽

Evanescent Wave ◽

Major Histocompatibility ◽

Peptide Antigen ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein

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The analysis of peptide affinity and its binding kinetics to DR1DW1 major histocompatibility complex protein

Biophysical Chemistry ◽

10.1016/s0301-4622(99)00024-1 ◽

1999 ◽

Vol 77 (2-3) ◽

pp. 183-194 ◽

Cited By ~ 5

Author(s):

Leonid M. Berezhkovskiy

Keyword(s):

Major Histocompatibility Complex ◽

Binding Kinetics ◽

Major Histocompatibility ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein ◽

Peptide Affinity

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An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.88.24.11276 ◽

1991 ◽

Vol 88 (24) ◽

pp. 11276-11280 ◽

Cited By ~ 112

Author(s):

T. J. Tsomides ◽

B. D. Walker ◽

H. N. Eisen

Keyword(s):

T Cells ◽

Major Histocompatibility Complex ◽

Cd8 T Cells ◽

Class I ◽

Major Histocompatibility ◽

Intact Cells ◽

Viral Peptide ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein

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Loss of T Cell Antigen Recognition Arising from Changes in Peptide and Major Histocompatibility Complex Protein Flexibility: Implications for Vaccine Design

Biophysical Journal ◽

10.1016/j.bpj.2012.11.370 ◽

2013 ◽

Vol 104 (2) ◽

pp. 60a

Author(s):

Francis K. Insaidoo ◽

Oleg Y. Borbulevych ◽

Moushumi Hossain ◽

Sujatha M. Santhanagopolan ◽

Tifany K. Baxter ◽

...

Keyword(s):

Major Histocompatibility Complex ◽

T Cell ◽

Protein Flexibility ◽

Vaccine Design ◽

Antigen Recognition ◽

Major Histocompatibility ◽

Cell Antigen ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein

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Peptide Modulation of Class I Major Histocompatibility Complex Protein Molecular Flexibility and the Implications for Immune Recognition

Journal of Biological Chemistry ◽

10.1074/jbc.m113.490664 ◽

2013 ◽

Vol 288 (34) ◽

pp. 24372-24381 ◽

Cited By ~ 33

Author(s):

William F. Hawse ◽

Brian E. Gloor ◽

Cory M. Ayres ◽

Kevin Kho ◽

Elizabeth Nuter ◽

...

Keyword(s):

Major Histocompatibility Complex ◽

Class I ◽

Immune Recognition ◽

Major Histocompatibility ◽

Molecular Flexibility ◽

Histocompatibility Complex ◽

Major Histocompatibility Complex Protein ◽

Complex Protein

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