Chemical Synthesis and Preliminary Structural Characterization of a Nitrous Acid Interstrand Cross-Linked Duplex DNA

1999 ◽  
Vol 121 (21) ◽  
pp. 5081-5082 ◽  
Author(s):  
Eric A. Harwood ◽  
Snorri Th. Sigurdsson ◽  
N. B. Fredrik Edfeldt ◽  
Brian R. Reid ◽  
Paul B. Hopkins
Keyword(s):  
Chemical Synthesis ◽  
Structural Characterization ◽  
Nitrous Acid ◽  
Duplex Dna

scholarly journals Chemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA

2015 ◽  
Vol 43 (7) ◽  
pp. 3434-3441 ◽  
Author(s):  
Nathan E. Price ◽  
Michael J. Catalano ◽  
Shuo Liu ◽  
Yinsheng Wang ◽  
Kent S. Gates
Keyword(s):  
Structural Characterization ◽  
Duplex Dna ◽  
Abasic Sites ◽  
Interstrand Cross Links ◽  
Cross Links

Soft chemical synthesis and structural characterization of Y2HfxTi2−xO7

2015 ◽  
Vol 41 (4) ◽  
pp. 5309-5317 ◽  
Author(s):  
Linggen Kong ◽  
Zhaoming Zhang ◽  
Massey de los Reyes ◽  
Inna Karatchevtseva ◽  
Gregory R. Lumpkin ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Structural Characterization ◽  
Soft Chemical Synthesis

scholarly journals Location ofN-Unsubstituted Glucosamine Residues in Heparan Sulfate

2002 ◽  
Vol 277 (51) ◽  
pp. 49247-49255 ◽  
Author(s):  
Camilla Westling ◽  
Ulf Lindahl
Keyword(s):  
Heparan Sulfate ◽  
Functional Properties ◽  
Structural Characterization ◽  
Nitrous Acid ◽  
Human Aorta ◽  
Linkage Region ◽  
Hexuronic Acid ◽  
Functional Implications ◽  
Sulfation Pattern

Functional properties of heparan sulfate (HS) are generally ascribed to the sulfation pattern of the polysaccharide. However, recently reported functional implications of rareN-unsubstituted glucosamine (GlcNH2) residues in native HS prompted our structural characterization of sequences around such residues. HS preparations were cleaved with nitrous acid at eitherN-sulfated orN-unsubstituted glucosamine units followed by reduction with NaB3H4. The labeled products were characterized following complementary deamination steps. The proportion of GlcNH2units varied from 0.7–4% of total glucosamine in different HS preparations. The GlcNH2units occurred largely clustered at the polysaccharide-protein linkage region in intestinal HS, also more peripherally in aortic HS. They were preferentially located withinN-acetylated domains, or in transition sequences betweenN-acetylated andN-sulfated domains, only 20–30% of the adjacent upstream and downstream disaccharide units beingN-sulfated. The nearest downstream (toward the polysaccharide-protein linkage) hexuronic acid was invariably GlcUA, whereas the upstream neighbor could be either GlcUA or IdoUA. The highly sulfated butN-unsubstituted disaccharide unit, -IdoUA2S-GlcNH26S-, was detected in human renal and porcine intestinal HS, but not in HS from human aorta. These results are interpreted in terms of a biosynthetic mechanism, whereby GlcNH2residues are formed through regulated, incomplete action of anN-deacetylase/N-sulfotransferase enzyme.

Chemical synthesis and structural characterization of small AuZn nanoparticles

2007 ◽  
Vol 86 (4) ◽  
pp. 441-446 ◽  
Author(s):  
E. Juárez-Ruiz ◽  
U. Pal ◽  
J.A. Lombardero-Chartuni ◽  
A. Medina ◽  
J.A. Ascencio
Keyword(s):  
Chemical Synthesis ◽  
Structural Characterization

scholarly journals Chemical synthesis and structural characterization of the RGD-protein decorsin: A potent inhibitor of platelet aggregation

1998 ◽  
Vol 7 (2) ◽  
pp. 433-444 ◽  
Author(s):  
Patrizia Polverino De Laureto ◽  
Elena Scaramella ◽  
Vincezo De Filippis ◽  
Oriano Marin ◽  
Maria Gabriella Doni ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Chemical Synthesis ◽  
Structural Characterization ◽  
Potent Inhibitor

Chemical synthesis and structural characterization of the substitution compound LaFe1−xCuxO3 (x=0–0.40)

2009 ◽  
Vol 116 (2-3) ◽  
pp. 645-648 ◽  
Author(s):  
Tullio Caronna ◽  
Francesca Fontana ◽  
Isabella Natali Sora ◽  
Renato Pelosato
Keyword(s):  
Chemical Synthesis ◽  
Structural Characterization
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