Determination of Statherin N-Terminal Peptide Conformation on Hydroxyapatite Crystals

2000 ◽  
Vol 122 (8) ◽  
pp. 1709-1716 ◽  
Author(s):  
Wendy J. Shaw ◽  
Joanna R. Long ◽  
John L. Dindot ◽  
Allison A. Campbell ◽  
Patrick S. Stayton ◽  
...  
Keyword(s):  
Peptide Conformation ◽  
Hydroxyapatite Crystals

NMR and CD conformational studies of bradykinin and its agonists and antagonists: application to receptor binding

1998 ◽  
Vol 76 (2-3) ◽  
pp. 257-266 ◽  
Author(s):  
George Kotovych ◽  
John R Cann ◽  
John M Stewart ◽  
Hitoshi Yamamoto
Keyword(s):  
Receptor Binding ◽  
Biological Function ◽  
Peptide Conformation ◽  
Biologically Active ◽  
New Drugs ◽  
Conformational Studies ◽  
Physiological Processes ◽  
Bradykinin Antagonists ◽  
Specific Receptors

Most physiological processes are regulated by peptides that perform their functions by interacting with specific receptors on cells. Specific conformations of the peptides are required for correct interactions to take place, and a knowledge of the biologically important conformation is vital for the understanding of biological function. Over the last few years extensive studies using nuclear magnetic resonance and circular dichroism have been carried out on bradykinin (Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9) and its antagonists with the objective of developing new drugs to combat severe pathologies associated with its production. In the present review, these techniques for the determination of peptide conformation are reviewed and applied to the study of bradykinin and its antagonists. Modeling of these conformational data in the presence of the B2 receptor or an antibody allows the biologically active conformations to be deduced and these are presented in this review.Key words: bradykinin antagonists, conformational analysis, NMR, CD, B2 receptor binding.

scholarly journals Methods of peptide conformation studies.

2001 ◽  
Vol 48 (4) ◽  
pp. 1091-1099 ◽  
Author(s):  
A Bierzyński
Keyword(s):  
Hydrogen Exchange ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Peptide Conformation ◽  
Short Review ◽  
Experimental Methods ◽  
Conformational Space ◽  
Conformational Studies ◽  
Leading Role

In solution most of the peptides assume multiple flexible conformations. Determination of the dominant conformers and evaluation of their populations is the aim of peptide conformation studies, in which theoretical and experimental methods play complementary roles. Molecular dynamics or Monte Carlo methods are quite effective in searching the conformational space accessible to a peptide but they are not able to estimate, precisely enough, the populations of various conformations. Therefore, they must be supplemented by experimental data. In this paper, a short review of the experimental methods, most widely used in peptide conformational studies, is presented. Among them NMR plays the leading role. Valuable information is also obtained from hydrogen exchange, fluorescence resonance energy transfer, and circular dichroism measurements. The advantages and shortcomings of these methods are discussed.

HRTEM simulation in determination of thickness and grain misorientation for hydroxyapatite crystals

2004 ◽  
Vol 49 (3) ◽  
pp. 343-352 ◽  
Author(s):  
E. I. Suvorova ◽  
P. A. Stadelmann ◽  
P. -A. Buffat
Keyword(s):  
Grain Misorientation ◽  
Hydroxyapatite Crystals

Galactic orbits of stars

1966 ◽  
Vol 25 ◽  
pp. 93-97
Author(s):  
Richard Woolley
Keyword(s):  
Globular Cluster ◽  
Potential Field ◽  
High Velocity ◽  
Velocity Vector ◽  
Variable Stars ◽  
The Sun ◽  
Proper Motions ◽  
Rr Lyrae ◽  
The Galaxy

It is now possible to determine proper motions of high-velocity objects in such a way as to obtain with some accuracy the velocity vector relevant to the Sun. If a potential field of the Galaxy is assumed, one can compute an actual orbit. A determination of the velocity of the globular clusterωCentauri has recently been completed at Greenwich, and it is found that the orbit is strongly retrograde in the Galaxy. Similar calculations may be made, though with less certainty, in the case of RR Lyrae variable stars.

Distance to SN 1987A and the LMC

1999 ◽  
Vol 190 ◽  
pp. 549-554
Author(s):  
Nino Panagia
Keyword(s):  
Angular Size ◽  
Large Magellanic Cloud ◽  
Magellanic Cloud ◽  
Light Curves ◽  
Distance Modulus ◽  
Absolute Size ◽  
Sn 1987A

Using the new reductions of the IUE light curves by Sonneborn et al. (1997) and an extensive set of HST images of SN 1987A we have repeated and improved Panagia et al. (1991) analysis to obtain a better determination of the distance to the supernova. In this way we have derived an absolute size of the ringRabs= (6.23 ± 0.08) x 1017cm and an angular sizeR″ = 808 ± 17 mas, which give a distance to the supernovad(SN1987A) = 51.4 ± 1.2 kpc and a distance modulusm–M(SN1987A) = 18.55 ± 0.05. Allowing for a displacement of SN 1987A position relative to the LMC center, the distance to the barycenter of the Large Magellanic Cloud is also estimated to bed(LMC) = 52.0±1.3 kpc, which corresponds to a distance modulus ofm–M(LMC) = 18.58±0.05.

International determination of the total motion of the pole

1961 ◽  
Vol 13 ◽  
pp. 29-41
Author(s):  
Wm. Markowitz
Keyword(s):  
Secular Motion ◽  
The Future

A symposium on the future of the International Latitude Service (I. L. S.) is to be held in Helsinki in July 1960. My report for the symposium consists of two parts. Part I, denoded (Mk I) was published [1] earlier in 1960 under the title “Latitude and Longitude, and the Secular Motion of the Pole”. Part II is the present paper, denoded (Mk II).

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