Molecular Basis for the DNA Sequence Selectivity of Ecteinascidin 736 and 743:  Evidence for the Dominant Role of Direct Readout via Hydrogen Bonding

1998 ◽  
Vol 120 (50) ◽  
pp. 13028-13041 ◽  
Author(s):  
Frederick C. Seaman ◽  
Laurence H. Hurley
Keyword(s):  
Hydrogen Bonding ◽  
Dna Sequence ◽  
Molecular Basis ◽  
Dominant Role ◽  
Sequence Selectivity ◽  
Direct Readout

DNA Sequence-Specific Reading by Echinomycin: Role of Hydrogen Bonding and Stacking Interactions

1994 ◽  
Vol 37 (11) ◽  
pp. 1602-1609 ◽  
Author(s):  
Jose Gallego ◽  
F. J. Luque ◽  
Modesto Orozco ◽  
Carolina Burgos ◽  
Julio Alvarez-Builla ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Dna Sequence ◽  
Stacking Interactions ◽  
Specific Reading

Bioinspired Insights into Silicic Acid Stabilization Mechanisms: The Dominant Role of Polyethylene Glycol-Induced Hydrogen Bonding

2014 ◽  
Vol 136 (11) ◽  
pp. 4236-4244 ◽  
Author(s):  
Melina Preari ◽  
Katrin Spinde ◽  
Joëlle Lazic ◽  
Eike Brunner ◽  
Konstantinos D. Demadis
Keyword(s):  
Hydrogen Bonding ◽  
Polyethylene Glycol ◽  
Silicic Acid ◽  
Dominant Role

Chronic Pain: Fundamental Scientific Considerations, Specifically for Legal Claims

2013 ◽  
Vol 18 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Robert J. Barth
Keyword(s):  
Health Outcomes ◽  
Pain Perception ◽  
Driving Forces ◽  
Psychological Treatment ◽  
Dominant Role ◽  
Meta Analysis ◽  
General Medicine ◽  
Pain Syndrome ◽  
Problematic Relationship

Abstract Scientific findings have indicated that psychological and social factors are the driving forces behind most chronic benign pain presentations, especially in a claim context, and are relevant to at least three of the AMA Guides publications: AMA Guides to Evaluation of Disease and Injury Causation, AMA Guides to Work Ability and Return to Work, and AMA Guides to the Evaluation of Permanent Impairment. The author reviews and summarizes studies that have identified the dominant role of financial, psychological, and other non–general medicine factors in patients who report low back pain. For example, one meta-analysis found that compensation results in an increase in pain perception and a reduction in the ability to benefit from medical and psychological treatment. Other studies have found a correlation between the level of compensation and health outcomes (greater compensation is associated with worse outcomes), and legal systems that discourage compensation for pain produce better health outcomes. One study found that, among persons with carpal tunnel syndrome, claimants had worse outcomes than nonclaimants despite receiving more treatment; another examined the problematic relationship between complex regional pain syndrome (CRPS) and compensation and found that cases of CRPS are dominated by legal claims, a disparity that highlights the dominant role of compensation. Workers’ compensation claimants are almost never evaluated for personality disorders or mental illness. The article concludes with recommendations that evaluators can consider in individual cases.

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