Measurements of Molecular Electrostatic Field Effects in Edge-to-Face Aromatic Interactions and CH-π Interactions with Implications for Protein Folding and Molecular Recognition

1998 ◽  
Vol 120 (43) ◽  
pp. 11192-11193 ◽  
Author(s):  
Eun-il Kim ◽  
Sunil Paliwal ◽  
Craig S. Wilcox
Keyword(s):  
Protein Folding ◽  
Molecular Recognition ◽  
Electrostatic Field ◽  
Π Interactions ◽  
Field Effects ◽  
Aromatic Interactions

Carbohydrate-Aromatic Interactions: The Role of Curvature on XH···π Interactions

2010 ◽  
Vol 114 (12) ◽  
pp. 4313-4324 ◽  
Author(s):  
R. Mahesh Kumar ◽  
M. Elango ◽  
V. Subramanian
Keyword(s):  
Π Interactions ◽  
Aromatic Interactions

Aromatic interactions in Glycochemistry: from molecular recognition to catalysis

2021 ◽  
Vol 28 ◽  
Author(s):  
Andrés González Santana ◽  
Laura Díaz-Casado ◽  
Laura Montalvillo ◽  
Ester Jiménez-Moreno ◽  
Enrique Mann ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Transition States ◽  
Carbohydrate Binding ◽  
Potential Influence ◽  
Chemical Structures ◽  
Receptor Complexes ◽  
Binding Domains ◽  
Aromatic Interactions ◽  
Aromatic Complexes ◽  
Recognition Motifs

: Aromatic platforms are ubiquitous recognition motifs occurring in protein carbohydrate binding domains (CBDs), RNA receptors and enzymes. They stabilize the glycoside/receptor complexes by participating in stacking CH/ interactions with either the - or - face of the corresponding pyranose units. In addition, the role played by aromatic units in the stabilization of glycoside cationic transition states has started being recognized in recent years. Extensive studies carried out during the last decade have allowed to dissect the main contributing forces that stabilize the carbohydrate/aromatic complexes, while helping delineate not only the standing relationship between the glycoside/aromatic chemical structures and the strength of this interaction, but also their potential influence on glycoside reactivity.

Quantification of CH⋅⋅⋅π Interactions: Implications on How Substituent Effects Influence Aromatic Interactions

2010 ◽  
Vol 16 (41) ◽  
pp. 12357-12362 ◽  
Author(s):  
Benjamin W. Gung ◽  
Bright U. Emenike ◽  
Michael Lewis ◽  
Kristin Kirschbaum
Keyword(s):  
Substituent Effects ◽  
Π Interactions ◽  
Aromatic Interactions

Substituent effects by 19F nuclear magnetic resonance: Polar and π-electron effects

1976 ◽  
Vol 29 (12) ◽  
pp. 2571 ◽  
Author(s):  
W Adcock ◽  
BD Gupta ◽  
T Khor
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Electrostatic Field ◽  
Chemical Shifts ◽  
Substituent Effects ◽  
Important Conclusion ◽  
Field Effects ◽  
Electron Distributions ◽  
Electron Effects ◽  
Nuclear Magnetic

A number of model substituted bicyclic aryl fluorides, including three new fluorobenzocycloalkenes, have been synthesized and their fluorine- 19 spectra measured. An analysis of the data leads to the important conclusion that electrostatic-field effects play an important role in determining aryl 19F chemical shifts. Further the relative π-electron distributions of several benzocycloalkenes are indicated.

Molecular Recognition at the Active Site of Factor Xa: Cation-π Interactions, Stacking on Planar Peptide Surfaces, and Replacement of Structural Water

2011 ◽  
Vol 18 (1) ◽  
pp. 213-222 ◽  
Author(s):  
Laura M. Salonen ◽  
Mareike C. Holland ◽  
Philip S. J. Kaib ◽  
Wolfgang Haap ◽  
Jörg Benz ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Active Site ◽  
Factor Xa ◽  
Structural Water ◽  
Π Interactions

Electrostatic field effects manifested in ferrocenyl metal complexes and the crystal structure of [Fe(η5-C5H5)(η5-C5H4CHNNHC5H4N)]·HCl

2001 ◽  
Vol 637-639 ◽  
pp. 311-317 ◽  
Author(s):  
Jack Silver ◽  
George R. Fern ◽  
John R. Miller ◽  
Elizabeth Slade ◽  
Mustafa Ahmet ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Metal Complexes ◽  
Electrostatic Field ◽  
Field Effects
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