Synthesis and Structural and Functional Evaluation of a Protein Modified with a β-Turn Mimic

Fabienne Jean; Eric Buisine; Oleg Melnyk; Hervé Drobecq; Benoît Odaert; Michel Hugues; Guy Lippens; André Tartar

doi:10.1021/ja972346o

Synthesis and Structural and Functional Evaluation of a Protein Modified with a β-Turn Mimic

Journal of the American Chemical Society ◽

10.1021/ja972346o ◽

1998 ◽

Vol 120 (24) ◽

pp. 6076-6083 ◽

Cited By ~ 8

Author(s):

Fabienne Jean ◽

Eric Buisine ◽

Oleg Melnyk ◽

Hervé Drobecq ◽

Benoît Odaert ◽

...

Keyword(s):

Functional Evaluation ◽

Turn Mimic

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A method for the functional evaluation of disability

PsycEXTRA Dataset ◽

10.1037/e534562008-005 ◽

1960 ◽

Author(s):

Norris D. Vestre

Keyword(s):

Functional Evaluation

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Functional Evaluation of Integrated Passenger Transportation Hub Based on Fuzzy Comprehensive Evaluation Method

CICTP 2020 ◽

10.1061/9780784483053.225 ◽

2020 ◽

Author(s):

Jianyou Zhao ◽

Yi Li ◽

Yuntao Ye

Keyword(s):

Evaluation Method ◽

Comprehensive Evaluation ◽

Fuzzy Comprehensive Evaluation ◽

Functional Evaluation ◽

Fuzzy Comprehensive Evaluation Method ◽

Comprehensive Evaluation Method ◽

Passenger Transportation

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Safety And Preliminary Efficacy of Magnetic Stimulation of Pelvic Floor with Hifem Technology in Urinary Incontinence

Medical & Clinical Research ◽

10.33140/mcr.03.02.10 ◽

2018 ◽

Vol 3 (2) ◽

Keyword(s):

Urinary Incontinence ◽

Pelvic Floor ◽

Magnetic Stimulation ◽

Muscle Tone ◽

Pelvic Floor Muscle ◽

Neuromuscular Control ◽

Ultrasound Elastography ◽

Functional Evaluation ◽

Muscle Injuries ◽

Stimulation Of

Introduction: BTL EMSELLA™ utilizes High-Intensity Focused Electromagnetic technology (HIFEM) to cause deep pelvic floor muscles stimulation and restoration of the neuromuscular control. Key effectiveness is based on focused electromagnetic energy, in-depth penetration and stimulation of the entire pelvic floor area. A single BTL EMSELLA™ session brings thousands of supramaximal pelvic floor muscle contractions, which are extremely important in muscle reeducation of incontinent patients. Objective: Prospective study to evaluate the safety and preliminary effectiveness of the use of BTL EMSELLA magnetic stimulation in urinary incontinence. Method: Thirty-two patients with light and moderate urinary incontinence were recruited to perform 6 sessions of BTL EMSELLA during three weeks of initial treatment. Follow-up after three months. The patients received sessions lasting 28 minutes, completing the different treatment protocols. Initially the patients underwent a quality of life test before and after treatment, evaluation with advanced ultrasound using elastography to measure the initial tissue's elasticity and be able to compare after treatment, clinical functional evaluation and urodynamic test. Results: No adverse reactions were observed. All the patients finished the treatment sessions. Two patients reported increased pain after treatment in the first session corresponding to a VAS scale greater than 5 with duration greater than three hours. The treatment was highly satisfactory in 84,4% of the patients. After the first three months the improvement was maintained in 77% of the patients. No muscle injuries were observed. Elastographic changes and improvement of muscle tone were detected by advanced ultrasound (elastography) in 100% of patients. Conclusions: BTL EMSELLA is safe, well tolerated and effective for the treatment of mild and moderate urinary incontinence. The observed elastographic changes demonstrate the improvement of pelvic floor muscle tone after treatment. A reduction in the symptoms of urinary incontinence was demonstrated. Recommendations: Continue increasing the number of cases for research and increase the variables that we have decided to incorporate in the next research section such as MRI and pressure calculation.

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