Oxidative DNA Cleavage by the Antitumor Antibiotic Leinamycin and Simple 1,2-Dithiolan-3-one 1-Oxides:  Evidence for Thiol-Dependent Conversion of Molecular Oxygen to DNA-Cleaving Oxygen Radicals Mediated by Polysulfides

1997 ◽  
Vol 119 (48) ◽  
pp. 11691-11692 ◽  
Author(s):  
Kaushik Mitra ◽  
Woongki Kim ◽  
J. Scott Daniels ◽  
Kent S. Gates
Keyword(s):  
Molecular Oxygen ◽  
Dna Cleavage ◽  
Oxygen Radicals ◽  
Antitumor Antibiotic ◽  
Dna Cleaving ◽  
Oxidative Dna Cleavage

scholarly journals Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage

2015 ◽  
Vol 51 (62) ◽  
pp. 12395-12398 ◽  
Author(s):  
C. Wende ◽  
N. Kulak
Keyword(s):  
Dna Cleavage ◽  
Metal Ion ◽  
Fluorescent Reporter ◽  
Dna Cleaving ◽  
Oxidative Dna Cleavage

A Cu(ii)-based peptidic DNA cleaving agent equipped with a Cu(ii)-sensing fluorescent reporter allows monitoring the fate of the nucleolytic metal ion.

Oxidative DNA cleavage by copper ternary complexes of 1,10-phenanthroline and ethylenediamine-sulfonamide derivatives

Polyhedron ◽  
2009 ◽  
Vol 28 (13) ◽  
pp. 2537-2544 ◽  
Author(s):  
Andreea Bodoki ◽  
Adriana Hangan ◽  
Luminita Oprean ◽  
Gloria Alzuet ◽  
Alfonso Castiñeiras ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Ternary Complexes ◽  
Oxidative Dna Cleavage

Studies related to antitumor antibiotics. Part VII. Synthesis of streptonigrin analogues and their single strand scission of DNA

1976 ◽  
Vol 54 (16) ◽  
pp. 2563-2572 ◽  
Author(s):  
J. William Lown ◽  
Soo-Khoon Sim
Keyword(s):  
Antitumor Activity ◽  
Dna Cleavage ◽  
Single Strand ◽  
Antitumor Antibiotic ◽  
Antitumor Antibiotics ◽  
Substitution Pattern ◽  
Circular Dna ◽  
Strand Scission ◽  
Independent Synthesis ◽  
Selective Catalysis

The syntheses of a group of 2-(o-nitrophenyl)- and 2-(o-aminophenyl)-5,8-quinolinediones which are structurally related to the antitumor antibiotic streptonigrin are described. Ambiguities in the position of required nucleophilic displacements are resolved by independent synthesis. The rates of single strand cleavage of PM2 ccc-DNA (covalently-closed circular-DNA) induced by these compounds are compared, which correlates with antitumor activity. The 2-(o-nitrophenyl) derivatives give consistently more rapid DNA cleavage than the 2-(o-aminophenyl) compounds. The autoxidations of the dihydroxyquinolines are subject to selective catalysis by Cu2+ on. 2-(o-Aminophenyl)-7-amino-6-methoxy-5,6-quinolinedione which has a substitution pattern most closely resembling streptonigrin also closely parallels the rate of scission of DNA of the latter in the presence of NADPH.

scholarly journals The Inhibition of Phenylhydroquinone-Induced Oxidative DNA Cleavage by Constituents of Moutan Cortex and Paeoniae Radix.

2000 ◽  
Vol 23 (2) ◽  
pp. 199-203 ◽  
Author(s):  
Tomoko OKUBO ◽  
Fumiko NAGAI ◽  
Takako SETO ◽  
Kanako SATOH ◽  
Keiko USHIYAMA ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Moutan Cortex ◽  
Paeoniae Radix ◽  
Oxidative Dna Cleavage

ChemInform Abstract: UCE1022, a New Antitumor Antibiotic with Topoisomerase I Mediated DNA Cleavage Activity, from Paecilomyces.

ChemInform ◽  
2010 ◽  
Vol 26 (11) ◽  
pp. no-no
Author(s):  
N. FUJII ◽  
Y. YAMASHITA ◽  
K. ANDO ◽  
T. AGATSUMA ◽  
Y. SAITOH ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Antitumor Antibiotic ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

Acid-accelerated DNA-cleaving activities of antitumor antibiotic varacin

2002 ◽  
pp. 2112-2113 ◽  
Author(s):  
Alex H. F. Lee ◽  
Albert S. C. Chan ◽  
Tianhu Li
Keyword(s):  
Antitumor Antibiotic ◽  
Dna Cleaving
Sign in / Sign up

Export Citation Format

Share Document