scholarly journals A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic MoleculesJ.Am.Chem.Soc.1995,117, 5179−5197

1996 ◽  
Vol 118 (9) ◽  
pp. 2309-2309 ◽  
Author(s):  
Wendy D. Cornell ◽  
Piotr Cieplak ◽  
Christopher I. Bayly ◽  
Ian R. Gould ◽  
Kenneth M. Merz ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Force Field ◽  
Second Generation

scholarly journals A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1995 ◽  
Vol 117 (19) ◽  
pp. 5179-5197 ◽  
Author(s):  
Wendy D. Cornell ◽  
Piotr Cieplak ◽  
Christopher I. Bayly ◽  
Ian R. Gould ◽  
Kenneth M. Merz ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Force Field ◽  
Second Generation ◽  
Organic Molecules

Calibrating nucleic acids torsional energetics in force-field: insights from model compounds

2001 ◽  
Vol 537 (1-3) ◽  
pp. 283-305 ◽  
Author(s):  
D Bosch ◽  
N Foloppe ◽  
N Pastor ◽  
L Pardo ◽  
M Campillo
Keyword(s):  
Nucleic Acids ◽  
Force Field ◽  
Model Compounds

scholarly journals 110 Refinement of force field torsion parameters for nucleic acids based on inclusion of conformation-dependent solvation effects

2013 ◽  
Vol 31 (sup1) ◽  
pp. 70-70 ◽  
Author(s):  
Marie Zgarbová ◽  
Michal Otyepka ◽  
Pavel Banáš ◽  
F. Javier Luque ◽  
Thomas E. Cheatham ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Force Field ◽  
Solvation Effects

scholarly journals Refinement of the Cornell et al. Nucleic Acids Force Field Based on Reference Quantum Chemical Calculations of Glycosidic Torsion Profiles

2011 ◽  
Vol 7 (9) ◽  
pp. 2886-2902 ◽  
Author(s):  
Marie Zgarbová ◽  
Michal Otyepka ◽  
Jiří Šponer ◽  
Arnošt Mládek ◽  
Pavel Banáš ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Force Field ◽  
Quantum Chemical Calculations ◽  
Quantum Chemical

scholarly journals Bridged Nucleic Acids Reloaded

2019 ◽  
Author(s):  
Alfonso Soler-Bistué ◽  
Angeles Zorreguieta ◽  
Marcelo E. Tolmasky
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
First Generation ◽  
Second Generation ◽  
Nucleotide Analogs ◽  
Great Hope ◽  
Locked Nucleic Acids ◽  
Near Future

Oligonucleotides are key compounds widely used for research, diagnostics, and therapeutics. The rapid increase in oligonucleotide-based applications, together with the progress in nucleic acids research, led to the design of nucleotide analogs that when being part of these oligomers enhance their efficiency, bioavailability, or stability. One of the most useful nucleotide analogs are the first-generation bridge nucleic acids (BNA), also known as locked nucleic acids (LNA), which were used in combination with ribonucleotides, deoxyribonucleotides, or other analogs to construct oligomers with diverse applications. However, there is still room to improve their efficiency, bioavailability, stability, and, importantly, toxicity. A second generation BNA, BNANC (2'-O,4'-aminoethylene bridged nucleic acid), has been recently made available. Oligomers containing these analogs not only showed less toxicity when compared to LNA-containing compounds but in some cases also exhibited higher specificity. Although there are still few applications where BNANC-containing compounds were researched, the results are very promising warranting more efforts in incorporating these analogs for other applications. Furthermore, newer BNA compounds will be introduced in the near future offering great hope to oligonucleotide-based fields of research and applications.

scholarly journals Bridged Nucleic Acids Reloaded

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2297 ◽  
Author(s):  
Alfonso Soler-Bistué ◽  
Angeles Zorreguieta ◽  
Marcelo E. Tolmasky
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
First Generation ◽  
Second Generation ◽  
Nucleotide Analogs ◽  
Great Hope ◽  
Locked Nucleic Acids ◽  
Near Future

Oligonucleotides are key compounds widely used for research, diagnostics, and therapeutics. The rapid increase in oligonucleotide-based applications, together with the progress in nucleic acids research, has led to the design of nucleotide analogs that, when part of these oligomers, enhance their efficiency, bioavailability, or stability. One of the most useful nucleotide analogs is the first-generation bridged nucleic acids (BNA), also known as locked nucleic acids (LNA), which were used in combination with ribonucleotides, deoxyribonucleotides, or other analogs to construct oligomers with diverse applications. However, there is still room to improve their efficiency, bioavailability, stability, and, importantly, toxicity. A second-generation BNA, BNANC (2′-O,4′-aminoethylene bridged nucleic acid), has been recently made available. Oligomers containing these analogs not only showed less toxicity when compared to LNA-containing compounds but, in some cases, also exhibited higher specificity. Although there are still few applications where BNANC-containing compounds have been researched, the promising results warrant more effort in incorporating these analogs for other applications. Furthermore, newer BNA compounds will be introduced in the near future, offering great hope to oligonucleotide-based fields of research and applications.

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