Bioorganometallic Chemistry. 8. The Molecular Recognition of Aromatic and Aliphatic Amino Acids and Substituted Aromatic and Aliphatic Carboxylic Acid Guests with Supramolecular (η5-Pentamethylcyclopentadienyl)rhodium−Nucleobase, Nucleoside, and Nucleotide Cyclic Trimer Hosts via Non-Covalent π−π and Hydrophobic Interactions in Water:  Steric, Electronic, and Conformational Parameters

1996 ◽  
Vol 118 (21) ◽  
pp. 4993-5001 ◽  
Author(s):  
Hong Chen ◽  
Seiji Ogo ◽  
Richard H. Fish
Keyword(s):  
Amino Acids ◽  
Carboxylic Acid ◽  
Molecular Recognition ◽  
Hydrophobic Interactions ◽  
Aliphatic Carboxylic Acid ◽  
Bioorganometallic Chemistry ◽  
Cyclic Trimer

Bio-organometallic Peptide Conjugates: Recent Advances in Their Synthesis and Prospects for Biomedical Application

2020 ◽  
Vol 24 (21) ◽  
pp. 2508-2523
Author(s):  
Johana Gómez ◽  
Diego Sierra ◽  
Constanza Cárdenas ◽  
Fanny Guzmán
Keyword(s):  
Amino Acids ◽  
Biomedical Application ◽  
Structural Diversity ◽  
Biological Properties ◽  
Therapeutic Agents ◽  
Organometallic Complexes ◽  
Chemical Behavior ◽  
Metal Compounds ◽  
Bioorganometallic Chemistry ◽  
Pharmacological Control

One area of organometallic chemistry that has attracted great interest in recent years is the syntheses, characterization and study of organometallic complexes conjugated to biomolecules with different steric and electronic properties as potential therapeutic agents against cancer and malaria, as antibiotics and as radiopharmaceuticals. This minireview focuses on the unique structural diversity that has recently been discovered in α- amino acids and the reactions of metallocene complexes with peptides having different chemical behavior and potential medical applications. Replacing α-amino acids with metallocene fragments is an effective way of selectively influencing the physicochemical, structural, electrochemical and biological properties of the peptides. Consequently, research in the field of bioorganometallic chemistry offers the opportunity to develop bioactive metal compounds as an innovative and promising approach in the search for pharmacological control of different diseases.

Aliphatic Carboxylic Acid as Hydrogen-Bond Donor for Converting CO2 and Epoxide into Cyclic Carbonate under Mild Conditions

2021 ◽  
Author(s):  
Zheng Wang ◽  
Yajun Wang ◽  
Qianjie Xie ◽  
Zhiying Fan ◽  
Yehua Shen
Keyword(s):  
Hydrogen Bond ◽  
Carboxylic Acid ◽  
Value Added ◽  
Cyclic Carbonate ◽  
Hydrogen Bond Donor ◽  
Title Reaction ◽  
Aliphatic Carboxylic Acid ◽  
Mild Conditions ◽  
Atmospheric Carbon

The coupling of CO2 and epoxide is promising way to reduce atmospheric carbon by converting it into value-added cyclic carbonate. Pursuing efficient catalysts is highly attractive for the title reaction....

Synthesis and Antibacterial Potency of 4-Methyl-2,7-dioxo-1,2,3,4,7,10- hexahydropyrido[2,3-ƒ]quinoxaline-8-carboxylic acid, Selected [a]-Fused Heterocyles and Acyclic Precursors

2007 ◽  
Vol 62 (11) ◽  
pp. 1453-1458 ◽  
Author(s):  
Yusuf M. Al-Hiari ◽  
Ali M. Qaisia ◽  
Mohammad Y.Abu Shuheil ◽  
Mustafa M. El-Abadelah ◽  
Wolfgang Voelter
Keyword(s):  
Amino Acids ◽  
Carboxylic Acid ◽  
Antibacterial Activities ◽  
Sodium Dithionite ◽  
E Coli ◽  
Pipecolinic Acid

The reaction of 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (7) with each of sarcosine and (±)-pipecolinic acid afforded the corresponding N-(4- oxoquinolin-7-yl)-α-amino acids 8 and 9. Reductive lactamization of the latter with sodium dithionite gave hexahydropyrido[2,3- f ]quinoxaline (10) and octahydrodipyrido[1,2-a : 2,3- f ]quinoxaline (11) derivatives, respectively. Compounds 8 - 11 and their homologs 1 - 6, accessible from (S)-proline, (2S, 4R)-4-hydroxyproline and (S)-tetrahydroisoquinoline-3-carboxylic acid exhibit good to excellent antibacterial activities against E. coli and S. aureus.

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