Pterin-Centered Radical as a Mechanistic Probe of the Second Step of Nitric Oxide Synthase

2010 ◽  
Vol 132 (14) ◽  
pp. 5105-5113 ◽  
Author(s):  
Joshua J. Woodward ◽  
Yaser NejatyJahromy ◽  
R. David Britt ◽  
Michael A. Marletta
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Second Step ◽  
Mechanistic Probe ◽  
Oxide Synthase

The Second Step of the Nitric Oxide Synthase Reaction: Evidence for Ferric-Peroxo as the Active Oxidant

2009 ◽  
Vol 131 (1) ◽  
pp. 297-305 ◽  
Author(s):  
Joshua J. Woodward ◽  
Michelle M. Chang ◽  
Nathaniel I. Martin ◽  
Michael A. Marletta
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Second Step ◽  
Oxide Synthase ◽  
Ferric Peroxo

scholarly journals Methylated Nω-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction

Biochemistry ◽  
2013 ◽  
Vol 52 (18) ◽  
pp. 3062-3073 ◽  
Author(s):  
Kristin Jansen Labby ◽  
Huiying Li ◽  
Linda J. Roman ◽  
Pavel Martásek ◽  
Thomas L. Poulos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Second Step ◽  
Oxide Synthase

Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling

2018 ◽  
Vol 181 ◽  
pp. 28-40 ◽  
Author(s):  
Igor Shamovsky ◽  
Graham Belfield ◽  
Richard Lewis ◽  
Frank Narjes ◽  
Lena Ripa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Electron Tunneling ◽  
Second Step ◽  
Theoretical Studies ◽  
Oxide Synthase

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

Nitric oxide synthase and cellac disease

2001 ◽  
Vol 120 (5) ◽  
pp. A684-A684
Author(s):  
I DANIELS ◽  
I MURRAY ◽  
W GODDARD ◽  
R LONG
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase

Inhibitory effect of melatonin on nitric oxide synthase in rat enteric nervous system

2001 ◽  
Vol 120 (5) ◽  
pp. A176-A176
Author(s):  
P KOPPITZ ◽  
M STORR ◽  
D SAUR ◽  
M KURJAK ◽  
H ALLESCHER
Keyword(s):  
Nitric Oxide ◽  
Nervous System ◽  
Nitric Oxide Synthase ◽  
Enteric Nervous System ◽  
Inhibitory Effect ◽  
Oxide Synthase
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