Synthesis and Surface Modification of Highly Monodispersed, Spherical Gold Nanoparticles of 50−200 nm

2009 ◽  
Vol 131 (47) ◽  
pp. 17042-17043 ◽  
Author(s):  
Steven D. Perrault ◽  
Warren C. W. Chan
Keyword(s):  
Gold Nanoparticles ◽  
Surface Modification ◽  
Spherical Gold Nanoparticles

Endocytosis and exocytosis processes of gold nanoparticle with erythrocyte ghosts

MRS Advances ◽  
2020 ◽  
Vol 5 (42) ◽  
pp. 2169-2172 ◽  
Author(s):  
Víctor Gómez Flores
Keyword(s):  
Gold Nanoparticles ◽  
Surface Modification ◽  
Sem Analysis ◽  
Erythrocyte Ghosts ◽  
Simple Diffusion ◽  
Membrane Interaction ◽  
Vis Spectroscopy ◽  
Plasmatic Membrane ◽  
Result Show ◽  
Spherical Gold Nanoparticles

AbstractThe interaction of spherical gold nanoparticles (AuNPs) of 20nm elaborated by Turkevich method with the erythrocytes ghosts (7-8 μm) cell membrane was evaluated. The AuNPs-Membrane interaction was determined using confocal microscope, Uv-Vis spectroscopy and SEM analysis. The result show that nanoparticles larger than 20nm are adhered to the erythrocyte ghost membrane due their size and surface modification. Smaller AuNPs enter onto the cell by simple diffusion through the plasmatic membrane voids, these data may favor the best design and application in the treatments applied in biomedicine.

scholarly journals Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ewelina Piktel ◽  
Łukasz Suprewicz ◽  
Joanna Depciuch ◽  
Sylwia Chmielewska ◽  
Karol Skłodowski ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Medical Devices ◽  
Multidrug Resistant ◽  
Resistance Mechanisms ◽  
Antimicrobial Spectrum ◽  
Antimicrobial Coatings ◽  
Low Toxicity ◽  
Spherical Gold Nanoparticles ◽  
Cost Efficient ◽  
Bactericidal Efficiency

AbstractMedical device-associated infections are a serious medical threat, particularly for patients with impaired mobility and/or advanced age. Despite a variety of antimicrobial coatings for medical devices being explored to date, only a limited number have been introduced for clinical use. Research into new bactericidal agents with the ability to eradicate pathogens, limit biofilm formation, and exhibit satisfactory biocompatibility, is therefore necessary and urgent. In this study, a series of varied-morphology gold nanoparticles in shapes of rods, peanuts, stars and spherical-like, porous ones with potent antibacterial activity were synthesized and thoroughly tested against spectrum of Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus clinical strains, as well as spectrum of uropathogenic Escherichia coli isolates. The optimization of gold nanoparticles synthesis allowed to develop nanomaterials, which are proved to be significantly more potent against tested microbes compared with the gold nanoformulations reported to date. Notably, their antimicrobial spectrum includes strains with different drug resistance mechanisms. Facile and cost-efficient synthesis of gold nanoparticles, remarkable bactericidal efficiency at nanogram doses, and low toxicity, underline their potential for development as a new coatings, as indicated by the example of urological catheters. The presented research fills a gap in microbial studies of non-spherical gold nanoparticles for the development of antimicrobial coatings targeting multidrug-resistant pathogens responsible for device-associated nosocomial infections.

Surface modification of gold nanoparticles and their monolayer behavior at the air/water interface

2011 ◽  
Vol 257 (7) ◽  
pp. 2756-2763 ◽  
Author(s):  
Chaio-Ling Hsu ◽  
Ke-Hsuan Wang ◽  
Chien-Hsiang Chang ◽  
Wen-Ping Hsu ◽  
Yuh-Lang Lee
Keyword(s):  
Gold Nanoparticles ◽  
Surface Modification ◽  
Water Interface ◽  
Air Water Interface
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