MgF3−and α-Galactose 1-Phosphate in the Active Site of β-Phosphoglucomutase Form a Transition State Analogue of Phosphoryl Transfer

Nicola J. Baxter; Andrea M. Hounslow; Matthew W. Bowler; Nicholas H. Williams; G. Michael Blackburn; Jonathan P. Waltho

doi:10.1021/ja905972m

MgF3−and α-Galactose 1-Phosphate in the Active Site of β-Phosphoglucomutase Form a Transition State Analogue of Phosphoryl Transfer

Journal of the American Chemical Society ◽

10.1021/ja905972m ◽

2009 ◽

Vol 131 (45) ◽

pp. 16334-16335 ◽

Cited By ~ 24

Author(s):

Nicola J. Baxter ◽

Andrea M. Hounslow ◽

Matthew W. Bowler ◽

Nicholas H. Williams ◽

G. Michael Blackburn ◽

...

Keyword(s):

Transition State ◽

Active Site ◽

Phosphoryl Transfer ◽

Transition State Analogue

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X-ray absorption analysis of the active site of Streptomyces antibioticus Tyrosinase upon binding of transition state analogue inhibitors

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2007.07.008 ◽

2007 ◽

Vol 465 (2) ◽

pp. 320-327 ◽

Cited By ~ 15

Author(s):

Luigi Bubacco ◽

Roberto Spinazze ◽

Stefano della Longa ◽

Maurizio Benfatto

Keyword(s):

Transition State ◽

Active Site ◽

Absorption Analysis ◽

X Ray ◽

Streptomyces Antibioticus ◽

Transition State Analogue ◽

Transition State Analogue Inhibitors ◽

X Ray Absorption

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Stabilization of a Transition-State Analogue at the Active Site of Yeast Cytosine Deaminase: Importance of Proton Transfers

The Journal of Physical Chemistry B ◽

10.1021/jp0670743 ◽

2007 ◽

Vol 111 (23) ◽

pp. 6501-6506 ◽

Cited By ~ 12

Author(s):

Qin Xu ◽

Haobo Guo ◽

Andrey Gorin ◽

Hong Guo

Keyword(s):

Transition State ◽

Active Site ◽

Cytosine Deaminase ◽

Transition State Analogue ◽

Proton Transfers ◽

Yeast Cytosine Deaminase

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Physical Nature of Intermolecular Interactions within cAMP-Dependent Protein Kinase Active Site: Differential Transition State Stabilization in Phosphoryl Transfer Reaction

The Journal of Physical Chemistry B ◽

10.1021/jp8040633 ◽

2008 ◽

Vol 112 (37) ◽

pp. 11819-11826 ◽

Cited By ~ 23

Author(s):

Pawel Szarek ◽

Edyta Dyguda-Kazimierowicz ◽

Akitomo Tachibana ◽

W. Andrzej Sokalski

Keyword(s):

Protein Kinase ◽

Transition State ◽

Intermolecular Interactions ◽

Active Site ◽

Transfer Reaction ◽

Physical Nature ◽

Phosphoryl Transfer ◽

Dependent Protein Kinase ◽

Transition State Stabilization ◽

Dependent Protein

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Does the Active Site Arginine Change the Nature of the Transition State for Alkaline Phosphatase-Catalyzed Phosphoryl Transfer?

Journal of the American Chemical Society ◽

10.1021/ja9932582 ◽

1999 ◽

Vol 121 (47) ◽

pp. 11022-11023 ◽

Cited By ~ 30

Author(s):

Patrick J. O'Brie ◽

Daniel Herschlag

Keyword(s):

Alkaline Phosphatase ◽

Transition State ◽

Active Site ◽

Phosphoryl Transfer

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Binding of a possible transition state analogue to the active site of carboxypeptidase A.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.82.20.6840 ◽

1985 ◽

Vol 82 (20) ◽

pp. 6840-6844 ◽

Cited By ~ 44

Author(s):

D. W. Christianson ◽

W. N. Lipscomb

Keyword(s):

Transition State ◽

Active Site ◽

Carboxypeptidase A ◽

Transition State Analogue

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Do Electrostatic Interactions with Positively Charged Active Site Groups Tighten the Transition State for Enzymatic Phosphoryl Transfer?

Journal of the American Chemical Society ◽

10.1021/ja0480421 ◽

2004 ◽

Vol 126 (38) ◽

pp. 11814-11819 ◽

Cited By ~ 33

Author(s):

Ivana Nikolic-Hughes ◽

Douglas C. Rees ◽

Daniel Herschlag

Keyword(s):

Transition State ◽

Active Site ◽

Electrostatic Interactions ◽

Phosphoryl Transfer ◽

Positively Charged

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Role of Glutamate-104 in Generating a Transition State Analogue Inhibitor at the Active Site of Cytidine Deaminase†

Biochemistry ◽

10.1021/bi951498y ◽

1996 ◽

Vol 35 (3) ◽

pp. 948-954 ◽

Cited By ~ 20

Author(s):

Dean C. Carlow ◽

Steven A. Short ◽

Richard Wolfenden

Keyword(s):

Transition State ◽

Active Site ◽

Cytidine Deaminase ◽

Transition State Analogue

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A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0604448103 ◽

2006 ◽

Vol 103 (40) ◽

pp. 14732-14737 ◽

Cited By ~ 56

Author(s):

N. J. Baxter ◽

L. F. Olguin ◽

M. Golicnik ◽

G. Feng ◽

A. M. Hounslow ◽

...

Keyword(s):

Transition State ◽

Active Site ◽

Trojan Horse ◽

Enzyme Active Site ◽

Transition State Analogue

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Faculty Opinions recommendation of High-energy intermediate or stable transition state analogue: theoretical perspective of the active site and mechanism of beta-phosphoglucomutase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1020107.228481 ◽

2004 ◽

Author(s):

Arieh Warshel

Keyword(s):

Transition State ◽

Active Site ◽

Theoretical Perspective ◽

High Energy ◽

Transition State Analogue

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Thermodynamics of a Transition State Analogue Inhibitor Binding toEscherichia coliChorismate Mutase: Probing the Charge State of an Active Site Residue and Its Role in Inhibitor Binding and Catalysis†,‡

Biochemistry ◽

10.1021/bi980217u ◽

1998 ◽

Vol 37 (25) ◽

pp. 9052-9057 ◽

Cited By ~ 3

Author(s):

Angela Y. Lee ◽

Sheng Zhang ◽

Palangpon Kongsaeree ◽

Jon Clardy ◽

Bruce Ganem ◽

...

Keyword(s):

Transition State ◽

Charge State ◽

Active Site ◽

Active Site Residue ◽

Inhibitor Binding ◽

Transition State Analogue

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