Catalytic Asymmetric Synthesis of α-Alkylidene-β-hydroxy Esters via Dynamic Kinetic Asymmetric Transformation Involving Ba-Catalyzed Direct Aldol Reaction

2009 ◽  
Vol 131 (31) ◽  
pp. 10842-10843 ◽  
Author(s):  
Akitake Yamaguchi ◽  
Shigeki Matsunaga ◽  
Masakatsu Shibasaki
Keyword(s):  
Asymmetric Synthesis ◽  
Aldol Reaction ◽  
Catalytic Asymmetric Synthesis ◽  
Direct Aldol Reaction ◽  
Hydroxy Esters ◽  
Catalytic Asymmetric ◽  
Asymmetric Transformation

scholarly journals Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3amide

2017 ◽  
Vol 8 (4) ◽  
pp. 3260-3269 ◽  
Author(s):  
Hidetoshi Noda ◽  
Fuyuki Amemiya ◽  
Karin Weidner ◽  
Naoya Kumagai ◽  
Masakatsu Shibasaki
Keyword(s):  
Asymmetric Synthesis ◽  
Hydroxamic Acid ◽  
Aldol Reaction ◽  
Propargylic Alcohols ◽  
Catalytic Asymmetric Synthesis ◽  
Direct Aldol Reaction ◽  
Catalytic Asymmetric

The catalyst comprising Cu(ii)/chiral hydroxamic acid was found to play a bifunctional role in the direct aldol reaction of α-N3amide to alkynyl CF3ketones.

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