scholarly journals High Resolution Heteronuclear Correlation NMR Spectroscopy of an Antimicrobial Peptide in Aligned Lipid Bilayers: Peptide−Water Interactions at the Water−Bilayer Interface

2009 ◽  
Vol 131 (31) ◽  
pp. 10830-10831 ◽  
Author(s):  
Riqiang Fu ◽  
Eric D. Gordon ◽  
Daniel J. Hibbard ◽  
Myriam Cotten
Keyword(s):  
Nmr Spectroscopy ◽  
High Resolution ◽  
Antimicrobial Peptide ◽  
Lipid Bilayers ◽  
Heteronuclear Correlation

Oligomerization of the antimicrobial peptide Protegrin-5 in a membrane-mimicking environment. Structural studies by high-resolution NMR spectroscopy

2016 ◽  
Vol 46 (3) ◽  
pp. 293-300 ◽  
Author(s):  
Konstantin S. Usachev ◽  
Olga A. Kolosova ◽  
Evelina A. Klochkova ◽  
Aidar R. Yulmetov ◽  
Albert V. Aganov ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
High Resolution ◽  
Antimicrobial Peptide ◽  
Structural Studies ◽  
High Resolution Nmr

scholarly journals On the Rational Drug Design for Hypertension through NMR Spectroscopy

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 12
Author(s):  
Eleni Chontzopoulou ◽  
Andreas G. Tzakos ◽  
Thomas Mavromoustakos
Keyword(s):  
Drug Delivery ◽  
Solid State ◽  
Nmr Spectroscopy ◽  
High Resolution ◽  
Lipid Bilayers ◽  
Rational Design ◽  
Peptide Hormone ◽  
Rational Drug Design ◽  
Rational Drug ◽  
The Stability

Antagonists of the AT1receptor (AT1R) are beneficial molecules that can prevent the peptide hormone angiotensin II from binding and activating the specific receptor causing hypertension in pathological states. This review article summarizes the multifaced applications of solid and liquid state high resolution nuclear magnetic resonance (NMR) spectroscopy in antihypertensive commercial drugs that act as AT1R antagonists. The 3D architecture of these compounds is explored through 2D NOESY spectroscopy and their interactions with micelles and lipid bilayers are described using solid state 13CP/MAS, 31P and 2H static solid state NMR spectroscopy. Due to their hydrophobic character, AT1R antagonists do not exert their optimum profile on the AT1R. Therefore, various vehicles are explored so as to effectively deliver these molecules to the site of action and to enhance their pharmaceutical efficacy. Cyclodextrins and polymers comprise successful examples of effective drug delivery vehicles, widely used for the delivery of hydrophobic drugs to the active site of the receptor. High resolution NMR spectroscopy provides valuable information on the physical-chemical forces that govern these drug:vehicle interactions, knowledge required to get a deeper understanding on the stability of the formed complexes and therefore the appropriateness and usefulness of the drug delivery system. In addition, it provides valuable information on the rational design towards the synthesis of more stable and efficient drug formulations.

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