Mechanism of Montmorillonite Catalysis in the Formation of RNA Oligomers

2009 ◽  
Vol 131 (37) ◽  
pp. 13369-13374 ◽  
Author(s):  
Prakash C. Joshi ◽  
Michael F. Aldersley ◽  
John W. Delano ◽  
James P. Ferris
Keyword(s):  
Rna Oligomers

scholarly journals Harnessing Chemical Energy for the Activation and Joining of Prebiotic Building Blocks

2019 ◽  
Author(s):  
Ziwei Liu ◽  
Long-Fei Wu ◽  
Jianfeng Xu ◽  
Claudia Bonfio ◽  
David Russell ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Carboxylic Acid ◽  
Peptide Nucleic Acid ◽  
Reactive Intermediates ◽  
Building Blocks ◽  
Acid System ◽  
Rna Oligomers ◽  
Prebiotic Activation ◽  
Simultaneous Activation ◽  
Acid Anhydrides

Simultaneous activation of carboxylates and phosphates provides multiple pathways for the generation of reactive intermediates, including mixed carboxylic acid-phosphoric acid anhydrides, for the synthesis of peptidyl-RNAs, peptides, RNA oligomers and primordial phospholipids. These results indicate that unified prebiotic activation chemistry could have enabled the joining of building blocks in aqueous solution from a common pool and enabled the progression of a system towards higher complexity foreshadowing the modern encapsulated peptide-nucleic acid system

A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Hao Jia ◽  
Ao Zhang ◽  
Yuquan Yang ◽  
Yaqi Cui ◽  
Jianrong Xu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Rapid Detection ◽  
Innovative Approach ◽  
Sensor System ◽  
System P ◽  
Rna Oligomers ◽  
Optical Microfiber

COVID-19 is a new strain of highly contagious coronavirus. Now, an innovative approach to detect it by combining DNA/RNA oligomers as aptamers and a GO coated optical microfiber as a sensor system.

scholarly journals Hydration effects on the duplex stability of phosphoramidate DNA--RNA oligomers

1997 ◽  
Vol 25 (4) ◽  
pp. 830-835 ◽  
Author(s):  
D. Barsky ◽  
M. E. Colvin ◽  
G. Zon ◽  
S. M. Gryaznov
Keyword(s):  
Duplex Stability ◽  
Rna Oligomers

Synthesis, physico-chemical and biological properties of DNA and RNA oligonucleotides containing short alkylamino internucleotide bond

2011 ◽  
Vol 76 (12) ◽  
pp. 1471-1486
Author(s):  
Milena Sobczak ◽  
Katarzyna Kubiak ◽  
Magdalena Janicka ◽  
Malgorzata Sierant ◽  
Barbara Mikolajczyk ◽  
...  
Keyword(s):  
Biological Properties ◽  
Protecting Group ◽  
Dna And Rna ◽  
Double Stranded Dna ◽  
Physico Chemical ◽  
Rna Oligomers ◽  
Phosphate Linkage ◽  
Sirna Molecule ◽  
Fetal Bovine ◽  
The Stability

The condensation of the 5′-O-DMT-3′-deoxy-3′-aminothymidine with 3′-O-TBDMS-thymidine- 5′-aldehyde, followed by reduction of the resultant imine derivative and removal of tert-butyldimethylsilyl (TBDMS) protecting group, provided a dimer (denoted as TNHT), which is a congener of dithymidine phosphate with the phosphate linkage 3′-O-P(O)(OH)-O-5′ replaced with an amino group (–NH–). After phosphitylation of the 3′-OH group, the dimer TNHT was introduced (by the standard phosphoramidite approach) into a central part of the nonadecathymidylate. This oligomer exhibited lower affinity to the complementary single and double stranded DNA complements as compared to unmodified T19 oligonucleotide. The cleavage of modified oligomer with the snake venom and calf spleen phosphodiesterases was completely suppressed at the site of modification. RNA oligomers containing the TNHT dimer were used for preparation of siRNA molecules directed towards mRNA of BACE1 (beta-site amyloid precursor protein cleaving enzyme). The presence of the TNHT units at the 3′-ends of the RNA strands of the siRNA molecule (the siRNA itself is an effective gene expression inhibitor for BACE1) preserved the gene silencing activity and improved the stability of the modified siRNA in 10% fetal bovine serum.

Crystal structure of the left-handed helical RNA oligomers

1984 ◽  
Vol 40 (a1) ◽  
pp. C45-C45
Author(s):  
K. Tomita ◽  
Y. Nakamura ◽  
A. Nishimura ◽  
S. Fujii ◽  
S. Uesugi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Left Handed ◽  
Rna Oligomers

An efficient approach for conversion of 5-substituted 2-thiouridines built in RNA oligomers into corresponding desulfured 4-pyrimidinone products

2015 ◽  
Vol 25 (16) ◽  
pp. 3100-3104 ◽  
Author(s):  
Anna Chwialkowska ◽  
Ewelina Wielgus ◽  
Grazyna Leszczynska ◽  
Milena Sobczak ◽  
Barbara Mikolajczyk ◽  
...  
Keyword(s):  
Efficient Approach ◽  
Rna Oligomers
Sign in / Sign up

Export Citation Format

Share Document