scholarly journals Escherichia coliAllows Efficient Modular Incorporation of Newly Isolated Quinomycin Biosynthetic Enzyme into Echinomycin Biosynthetic Pathway for Rational Design and Synthesis of Potent Antibiotic Unnatural Natural Product

2009 ◽  
Vol 131 (26) ◽  
pp. 9347-9353 ◽  
Author(s):  
Kenji Watanabe ◽  
Kinya Hotta ◽  
Mino Nakaya ◽  
Alex P. Praseuth ◽  
Clay C. C. Wang ◽  
...  
Keyword(s):  
Natural Product ◽  
Rational Design ◽  
Biosynthetic Pathway ◽  
Biosynthetic Enzyme ◽  
Design And Synthesis

scholarly journals Rational Design and Synthesis of Right-Handed d-Sulfono-γ-AApeptide Helical Foldamers as Potent Inhibitors of Protein–Protein Interactions

2020 ◽  
Vol 85 (16) ◽  
pp. 10552-10560
Author(s):  
Peng Sang ◽  
Yan Shi ◽  
Pirada Higbee ◽  
Minghui Wang ◽  
Sami Abdulkadir ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Rational Design ◽  
Protein Protein Interactions ◽  
Design And Synthesis

Rational design and synthesis of novel Syk-kinase inhibitors

2012 ◽  
Vol 22 (2) ◽  
pp. 73-74 ◽  
Author(s):  
Alexey A. Zeifman ◽  
Ilya Yu. Titov ◽  
Igor V. Svitanko ◽  
Tatiana V. Rakitina ◽  
Aleksey V. Lipkin ◽  
...  
Keyword(s):  
Rational Design ◽  
Kinase Inhibitors ◽  
Design And Synthesis ◽  
Syk Kinase

scholarly journals The Tripod for Bacterial Natural Product Discovery: Genome Mining, Silent Pathway Induction, and Mass Spectrometry-Based Molecular Networking

mSystems ◽  
2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Daniela B. B. Trivella ◽  
Rafael de Felicio
Keyword(s):  
Mass Spectrometry ◽  
Natural Products ◽  
Natural Product ◽  
Biosynthetic Pathway ◽  
Genome Mining ◽  
Chemical Compounds ◽  
Gene Clusters ◽  
Tandem Mass ◽  
Molecular Networking ◽  
Natural Product Discovery

ABSTRACT Natural products are the richest source of chemical compounds for drug discovery. Particularly, bacterial secondary metabolites are in the spotlight due to advances in genome sequencing and mining, as well as for the potential of biosynthetic pathway manipulation to awake silent (cryptic) gene clusters under laboratory cultivation. Further progress in compound detection, such as the development of the tandem mass spectrometry (MS/MS) molecular networking approach, has contributed to the discovery of novel bacterial natural products. The latter can be applied directly to bacterial crude extracts for identifying and dereplicating known compounds, therefore assisting the prioritization of extracts containing novel natural products, for example. In our opinion, these three approaches—genome mining, silent pathway induction, and MS-based molecular networking—compose the tripod for modern bacterial natural product discovery and will be discussed in this perspective.

Rational design and synthesis of multimorphology mesoporous carbon@silica nanoparticles with tailored structure

Carbon ◽  
2021 ◽  
Author(s):  
Yajuan Zhao ◽  
Haolin Lyu ◽  
Yujie Liu ◽  
Wenjie Liu ◽  
Yong Tian ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Mesoporous Carbon ◽  
Rational Design ◽  
Design And Synthesis

scholarly journals Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton′s Tyrosine Kinase (BTK), LFM-A13 [α-Cyano-β-Hydroxy-β-Methyl-N-(2,5-Dibromophenyl)Propenamide]

1999 ◽  
Vol 274 (14) ◽  
pp. 9587-9599 ◽  
Author(s):  
Sandeep Mahajan ◽  
Sutapa Ghosh ◽  
Elise A. Sudbeck ◽  
Yaguo Zheng ◽  
Suzanne Downs ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Rational Design ◽  
Design And Synthesis

3D hierarchically mesoporous Cu-doped NiO nanostructures as high-performance anode materials for lithium ion batteries

CrystEngComm ◽  
2015 ◽  
Vol 17 (48) ◽  
pp. 9336-9347 ◽  
Author(s):  
Jingyun Ma ◽  
Longwei Yin ◽  
Tairu Ge
Keyword(s):  
Porous Structure ◽  
Lithium Ion Batteries ◽  
Surface Area ◽  
Anode Materials ◽  
High Performance ◽  
Rational Design ◽  
Three Dimensional ◽  
Lithium Ion ◽  
Design And Synthesis ◽  
Hierarchically Porous Structure

We report on the rational design and synthesis of three dimensional (3D) Cu-doped NiO architectures with an adjustable chemical component, surface area, and hierarchically porous structure as anodes for lithium ion battery.

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