Reduced or Diminished Stabilization of the Telomere G-Quadruplex and Inhibition of Telomerase by Small Chemical Ligands under Molecular Crowding Condition

2009 ◽  
Vol 131 (30) ◽  
pp. 10430-10438 ◽  
Author(s):  
Zhao Chen ◽  
Ke-wei Zheng ◽  
Yu-hua Hao ◽  
Zheng Tan
Keyword(s):  
Molecular Crowding ◽  
G Quadruplex ◽  
Small Chemical

Molecular Crowding Regulates the Structural Switch of the DNA G-Quadruplex†

Biochemistry ◽  
2002 ◽  
Vol 41 (50) ◽  
pp. 15017-15024 ◽  
Author(s):  
Daisuke Miyoshi ◽  
Akihiro Nakao ◽  
Naoki Sugimoto
Keyword(s):  
Molecular Crowding ◽  
G Quadruplex

Incorporation of O6-methylguanine restricts the conformational conversion of the human telomere G-quadruplex under molecular crowding conditions

2016 ◽  
Vol 52 (9) ◽  
pp. 1903-1906 ◽  
Author(s):  
Andong Zhao ◽  
Chuanqi Zhao ◽  
Hisae Tateishi-Karimata ◽  
Jinsong Ren ◽  
Naoki Sugimoto ◽  
...  
Keyword(s):  
Parallel Structure ◽  
Molecular Crowding ◽  
G Quadruplex ◽  
Human Telomere ◽  
Conformational Conversion

O6-methylguanine incorporation impeded the conformational conversion of G-quadruplex from a hybrid to a parallel structure under molecular crowding conditions.

scholarly journals The Effects of Molecular Crowding on the Structure and Stability of G-Quadruplexes with an Abasic Site

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Takeshi Fujimoto ◽  
Shu-ichi Nakano ◽  
Daisuke Miyoshi ◽  
Naoki Sugimoto
Keyword(s):  
Site Effects ◽  
Enthalpy Change ◽  
Molecular Crowding ◽  
Abasic Site ◽  
Structure And Stability ◽  
Quadruplex Structure ◽  
Abasic Sites ◽  
Crowding Effects ◽  
G Quadruplex ◽  
Quadruplex Formation

Both cellular environmental factors and chemical modifications critically affect the properties of nucleic acids. However, the structure and stability of DNA containing abasic sites under cell-mimicking molecular crowding conditions remain unclear. Here, we investigated the molecular crowding effects on the structure and stability of the G-quadruplexes including a single abasic site. Structural analysis by circular dichroism showed that molecular crowding by PEG200 did not affect the topology of the G-quadruplex structure with or without an abasic site. Thermodynamic analysis further demonstrated that the degree of stabilization of the G-quadruplex by molecular crowding decreased with substitution of an abasic site for a single guanine. Notably, we found that the molecular crowding effects on the enthalpy change for G-quadruplex formation had a linear relationship with the abasic site effects depending on its position. These results are useful for predicting the structure and stability of G-quadruplexes with abasic sites in the cell-mimicking conditions.

Hsa‐miR‐1587 G‐quadruplex formation and dimerization induced by NH4+, molecular crowding environment and jatrorrhizine derivatives

Talanta ◽  
2018 ◽  
Vol 179 ◽  
pp. 337-343 ◽  
Author(s):  
Wei Tan ◽  
Long Yi ◽  
Zhentao Zhu ◽  
Lulu Zhang ◽  
Jiang Zhou ◽  
...  
Keyword(s):  
Molecular Crowding ◽  
G Quadruplex ◽  
Quadruplex Formation

Human Telomeric DNA Forms Parallel-Stranded Intramolecular G-Quadruplex in K+Solution under Molecular Crowding Condition

2007 ◽  
Vol 129 (36) ◽  
pp. 11185-11191 ◽  
Author(s):  
Yong Xue ◽  
Zhong-yuan Kan ◽  
Quan Wang ◽  
Yuan Yao ◽  
Jiang Liu ◽  
...  
Keyword(s):  
Molecular Crowding ◽  
Telomeric Dna ◽  
G Quadruplex

Study on effects of molecular crowding on G-quadruplex-ligand binding and ligand-mediated telomerase inhibition

Methods ◽  
2013 ◽  
Vol 64 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Hidenobu Yaku ◽  
Takashi Murashima ◽  
Hisae Tateishi-Karimata ◽  
Shu-ichi Nakano ◽  
Daisuke Miyoshi ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Molecular Crowding ◽  
Telomerase Inhibition ◽  
G Quadruplex

The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: Biophysical and molecular modeling studies

Biochimie ◽  
2011 ◽  
Vol 93 (8) ◽  
pp. 1318-1327 ◽  
Author(s):  
Luigi Petraccone ◽  
Iolanda Fotticchia ◽  
Annunziata Cummaro ◽  
Bruno Pagano ◽  
Luca Ginnari-Satriani ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Molecular Crowding ◽  
Parallel Form ◽  
Modeling Studies ◽  
G Quadruplex ◽  
Molecular Modeling Studies

Conformational change of a G-quadruplex under molecular crowding conditions

2019 ◽  
Vol 38 (9) ◽  
pp. 2575-2581
Author(s):  
Ji Hoon Han ◽  
Ji Hoon Kim ◽  
Seog K. Kim ◽  
Yoon Jung Jang
Keyword(s):  
Conformational Change ◽  
Molecular Crowding ◽  
G Quadruplex
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