PAMAM Dendrimers Undergo pH Responsive Conformational Changes without Swelling

2009 ◽  
Vol 131 (8) ◽  
pp. 2798-2799 ◽  
Author(s):  
Yi Liu ◽  
Vyacheslav S. Bryantsev ◽  
Mamadou S. Diallo ◽  
William A. Goddard III
Keyword(s):  
Conformational Changes ◽  
Pamam Dendrimers ◽  
Ph Responsive

Unusual pH-Dependent Polarity Changes in PAMAM Dendrimers:  Evidence for pH-Responsive Conformational Changes

2000 ◽  
Vol 33 (25) ◽  
pp. 9169-9172 ◽  
Author(s):  
Wei Chen ◽  
Donald A. Tomalia ◽  
James L. Thomas
Keyword(s):  
Conformational Changes ◽  
Pamam Dendrimers ◽  
Ph Responsive ◽  
Ph Dependent

Graphene oxide based DNA nanoswitches as a programmable pH-responsive biosensor

2016 ◽  
Vol 8 (38) ◽  
pp. 6982-6985 ◽  
Author(s):  
Fengyan Luo ◽  
Qiang Xi ◽  
Jianhui Jiang ◽  
Ruqin Yu
Keyword(s):  
Graphene Oxide ◽  
Conformational Changes ◽  
Selective Adsorption ◽  
Dna Probes ◽  
Ph Responsive

We developed a programmable pH-responsive biosensor by combining the conformational changes of DNA probes and GO-mediated selective adsorption.

Conformational Changes of Polyamidoamine (PAMAM) Dendrimers Adsorbed on Silica Substrates

2011 ◽  
Vol 44 (13) ◽  
pp. 5069-5071 ◽  
Author(s):  
Laura Mureşan ◽  
Plinio Maroni ◽  
Ionel Popa ◽  
Maria Porus ◽  
Rémi Longtin ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Pamam Dendrimers ◽  
Silica Substrates

scholarly journals Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 162 ◽  
Author(s):  
Mengen Zhang ◽  
Jingyi Zhu ◽  
Yun Zheng ◽  
Rui Guo ◽  
Shige Wang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Drug Release ◽  
Cancer Cells ◽  
Pamam Dendrimers ◽  
In Vitro Cytotoxicity ◽  
Morphological Observation ◽  
Acidic Ph ◽  
Ph Responsive ◽  
Targeted Inhibition

We present here the development of multifunctional doxorubicin (DOX)-conjugated poly(amidoamine) (PAMAM) dendrimers as a unique platform for pH-responsive drug release and targeted chemotherapy of cancer cells. In this work, we covalently conjugated DOX onto the periphery of partially acetylated and folic acid (FA)-modified generation 5 (G5) PAMAM dendrimers through a pH-sensitive cis-aconityl linkage to form the G5.NHAc-FA-DOX conjugates. The formed dendrimer conjugates were well characterized using different methods. We show that DOX release from the G5.NHAc-FA-DOX conjugates follows an acid-triggered manner with a higher release rate under an acidic pH condition (pH = 5 or 6, close to the acidic pH of tumor microenvironment) than under a physiological pH condition. Both in vitro cytotoxicity evaluation and cell morphological observation demonstrate that the therapeutic activity of dendrimer-DOX conjugates against cancer cells is absolutely related to the DOX drug released. More importantly, the FA conjugation onto the dendrimers allowed a specific targeting to cancer cells overexpressing FA receptors (FAR), and allowed targeted inhibition of cancer cells. The developed G5.NHAc-FA-DOX conjugates may be used as a promising nanodevice for targeted cancer chemotherapy.

A pH responsive fluorescent probe based on dye modified i-motif nucleic acids

2018 ◽  
Vol 16 (48) ◽  
pp. 9402-9408 ◽  
Author(s):  
Pan Li ◽  
Zhe Chen ◽  
Yishun Huang ◽  
Jing Li ◽  
Fan Xiao ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Fluorescent Probe ◽  
Conformational Changes ◽  
Ph Responsive ◽  
Ph Variation

DNA-AIEgen hybrids show pH-responsive AIE effects induced by the conformational changes of DNA upon pH variation.

Influence of Calcium Ions on the Plant Cell Surface: Membrane Fusions and Conformational Changes

1974 ◽  
Vol 32 ◽  
pp. 154-155
Author(s):  
D. James Morré ◽  
Charles E. Bracker ◽  
William J. VanDerWoude
Keyword(s):  
Cell Wall ◽  
Cell Surface ◽  
Conformational Changes ◽  
Calcium Ions ◽  
Surface Membrane ◽  
Carboxyl Groups ◽  
Cross Linking ◽  
Ultrastructural Evidence ◽  
Glycine Max L ◽  
Wall Extensibility

Calcium ions in the concentration range 5-100 mM inhibit auxin-induced cell elongation and wall extensibility of plant stems. Inhibition of wall extensibility requires that the tissue be living; growth inhibition cannot be explained on the basis of cross-linking of carboxyl groups of cell wall uronides by calcium ions. In this study, ultrastructural evidence was sought for an interaction of calcium ions with some component other than the wall at the cell surface of soybean (Glycine max (L.) Merr.) hypocotyls.

Role of spectrin in membrane fusion and in shape change of human erythrocyte ghost

1978 ◽  
Vol 36 (2) ◽  
pp. 328-329
Author(s):  
Hideo Hayashi ◽  
Yoshikazu Hirai ◽  
John T. Penniston
Keyword(s):  
Conformational Changes ◽  
Human Erythrocyte ◽  
Shape Change ◽  
Membrane Surface ◽  
Slight Modification ◽  
Active Role ◽  
Main Role ◽  
Bank Blood ◽  
Human Erythrocyte Ghost

Spectrin is a membrane associated protein most of which properties have been tentatively elucidated. A main role of the protein has been assumed to give a supporting structure to inside of the membrane. As reported previously, however, the isolated spectrin molecule underwent self assemble to form such as fibrous, meshwork, dispersed or aggregated arrangements depending upon the buffer suspended and was suggested to play an active role in the membrane conformational changes. In this study, the role of spectrin and actin was examined in terms of the molecular arrangements on the erythrocyte membrane surface with correlation to the functional states of the ghosts.Human erythrocyte ghosts were prepared from either freshly drawn or stocked bank blood by the method of Dodge et al with a slight modification as described before. Anti-spectrin antibody was raised against rabbit by injection of purified spectrin and partially purified.

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