scholarly journals One-Pot Multicomponent Coupling Methods for the Synthesis of Diastereo- and Enantioenriched (Z)-Trisubstituted Allylic Alcohols

2009 ◽  
Vol 131 (24) ◽  
pp. 8434-8445 ◽  
Author(s):  
Michael H. Kerrigan ◽  
Sang-Jin Jeon ◽  
Young K. Chen ◽  
Luca Salvi ◽  
Patrick J. Carroll ◽  
...  
Keyword(s):  
Allylic Alcohols ◽  
One Pot ◽  
Coupling Methods ◽  
Multicomponent Coupling

ChemInform Abstract: One-Pot Multicomponent Coupling Methods for the Synthesis of Diastereo- and Enantioenriched (Z)-Trisubstituted Allylic Alcohols.

ChemInform ◽  
2009 ◽  
Vol 40 (45) ◽  
Author(s):  
Michael H. Kerrigan ◽  
Sang-Jin Jeon ◽  
Young K. Chen ◽  
Luca Salvi ◽  
Patrick J. Carroll ◽  
...  
Keyword(s):  
Allylic Alcohols ◽  
One Pot ◽  
Coupling Methods ◽  
Multicomponent Coupling

A Domino Heck Coupling–Cyclization–Dehydrogenative Strategy for the One-Pot Synthesis of Quinolines

Synthesis ◽  
2021 ◽  
Author(s):  
Santanu Ghora ◽  
Chinnabattigalla Sreenivasulu ◽  
Gedu Satyanarayana
Keyword(s):  
Functional Group ◽  
Exchange Process ◽  
Palladium Catalysis ◽  
Allylic Alcohols ◽  
Heck Coupling ◽  
One Pot ◽  
Synthetic Process ◽  
Intramolecular Condensation ◽  
The One

AbstractAn efficient, one-pot, domino synthesis of quinolines via the coupling of iodoanilines with allylic alcohols facilitated by palladium catalysis is described. The overall synthetic process involves an intermolecular Heck coupling between 2-iodoanilines and allylic alcohols, intramolecular condensation of in situ generated ketones with an internal amine functional group, and a dehydrogenation sequence. Notably, this protocol occurs in water as a green solvent. Significantly, the method exhibits broad substrate scope and is applied for the synthesis of deuterated quinolines through a deuterium-exchange process.

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