Visible Light Excitable Zn2+Fluorescent Sensor Derived from an Intramolecular Charge Transfer Fluorophore and Its in Vitro and in Vivo Application

2009 ◽  
Vol 131 (4) ◽  
pp. 1460-1468 ◽  
Author(s):  
Fang Qian ◽  
Changli Zhang ◽  
Yumin Zhang ◽  
Weijiang He ◽  
Xiang Gao ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Visible Light ◽  
Intramolecular Charge Transfer ◽  
Fluorescent Sensor

scholarly journals A Novel Dialkylamino GFP Chromophore as an Environment-Polarity Sensor Reveals the Role of Twisted Intramolecular Charge Transfer

Chemosensors ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 234
Author(s):  
Cheng Chen ◽  
Sean A. Boulanger ◽  
Anatolii I. Sokolov ◽  
Mikhail S. Baranov ◽  
Chong Fang
Keyword(s):  
Charge Transfer ◽  
Transient Absorption ◽  
Fluorescent Protein ◽  
Intramolecular Charge Transfer ◽  
Multivariable Analysis ◽  
Solvent Polarity ◽  
Dimethylamino Group ◽  
Twisted Intramolecular Charge Transfer

We discovered a novel fluorophore by incorporating a dimethylamino group (–NMe2) into the conformationally locked green fluorescent protein (GFP) scaffold. It exhibited a marked solvent-polarity-dependent fluorogenic behavior and can potentially find broad applications as an environment-polarity sensor in vitro and in vivo. The ultrafast femtosecond transient absorption (fs-TA) spectroscopy in combination with quantum calculations revealed the presence of a twisted intramolecular charge transfer (TICT) state, which is formed by rotation of the –NMe2 group in the electronic excited state. In contrast to the bright fluorescent state (FS), the TICT state is dark and effectively quenches fluorescence upon formation. We employed a newly developed multivariable analysis approach to the FS lifetime in various solvents and showed that the FS → TICT reaction barrier is mainly modulated by H-bonding capability instead of viscosity of the solvent, accounting for the observed polarity dependence. These deep mechanistic insights are further corroborated by the dramatic loss of fluorogenicity for two similar GFP-derived chromophores in which the rotation of the –NMe2 group is inhibited by structural locking.

Extending the excitation wavelength from UV to visible light for a europium complex-based mitochondria targetable luminescent probe for singlet oxygen

2018 ◽  
Vol 47 (37) ◽  
pp. 12852-12857 ◽  
Author(s):  
Hua Ma ◽  
Xin Wang ◽  
Bo Song ◽  
Liu Wang ◽  
Zhixin Tang ◽  
...  
Keyword(s):  
Visible Light ◽  
Singlet Oxygen ◽  
Europium Complex ◽  
Excitation Wavelength ◽  
Luminescent Probe ◽  
Luminescence Detection

A visible-light-excitable Eu3+ complex-based luminescent probe for the time-gated luminescence detection of singlet oxygen in vitro and in vivo.

A new visible-light-excitable ICT-CHEF-mediated fluorescence ‘turn-on’ probe for the selective detection of Cd2+ in a mixed aqueous system with live-cell imaging

2015 ◽  
Vol 44 (12) ◽  
pp. 5763-5770 ◽  
Author(s):  
Shyamaprosad Goswami ◽  
Krishnendu Aich ◽  
Sangita Das ◽  
Chitrangada Das Mukhopadhyay ◽  
Deblina Sarkar ◽  
...  
Keyword(s):  
Visible Light ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Aqueous System ◽  
Live Cell ◽  
Selective Detection ◽  
Turn On ◽  
Fluorescence Turn On

A new quinoline based sensor was developed and applied for the selective detection of Cd2+ both in vitro and in vivo.

Protective Effect of Fucoxanthin Isolated from Laminaria japonica against Visible Light-Induced Retinal Damage Both in Vitro and in Vivo

2016 ◽  
Vol 64 (2) ◽  
pp. 416-424 ◽  
Author(s):  
Yixiang Liu ◽  
Meng Liu ◽  
Xichun Zhang ◽  
Qingchou Chen ◽  
Haixiu Chen ◽  
...  
Keyword(s):  
Visible Light ◽  
Protective Effect ◽  
Laminaria Japonica ◽  
Retinal Damage

scholarly journals Red Room-Temperature Phosphorescent Diimides: Molecular Design and Application

2019 ◽  
Author(s):  
Jiajun Du ◽  
Fan Liao ◽  
Ziye Wu ◽  
Wenhuan Huang ◽  
Fei Li ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Room Temperature ◽  
Molecular Design ◽  
Intramolecular Charge Transfer ◽  
Imaging Studies ◽  
Oxygen Sensitive ◽  
Photo Induced Electron Transfer ◽  
Naphthalene Diimides ◽  
Transfer State

N-Substituted naphthalene diimides (NDIs) were explored as purely organic room temperature phosphorescence (RTP) materials based on the strategy of intramolecular charge-transfer (ICT) mediation. A series of NDIs were designed and investigated for their luminescence properties. All emissive NDIs exhibited similar red RTP (emission range from ~600 to ~800 nm) in solid state media; the quantum yield (QY) of the obtained RTP relies heavily on the N-substitution. From poor to moderate to strong donor moieties, the QY increases but suddenly disappears. First-principle calculations reveal that a “sweet spot” for strong NDI RTP exists: while a suitable charge-transfer state can enhance RTP, a strong donor may cause total triplet quenching through the photo-induced electron transfer (PET) mechanism. Furthermore, combining NDI aggregation effects, we realized the reddest RTP ever reported for purely organic materials (Max emission = 675 nm, QY = 21.7%). Given the red emission, respectable QY and oxygen sensitive properties for some of the NDIs, they were tested as imaging agents for in vivo imaging studies.

Facial Control Intramolecular Charge Transfer of Quinoid Conjugated Polymers for Efficient in Vivo NIR-II Imaging

2019 ◽  
Vol 11 (18) ◽  
pp. 16311-16319 ◽  
Author(s):  
Wansu Zhang ◽  
Ting Huang ◽  
Jiewei Li ◽  
Pengfei Sun ◽  
Yufeng Wang ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Conjugated Polymers ◽  
Intramolecular Charge Transfer

scholarly journals Visible-light-induced intramolecular charge transfer in the radical spirocyclisation of indole-tethered ynones

2020 ◽  
Vol 11 (5) ◽  
pp. 1353-1360 ◽  
Author(s):  
Hon Eong Ho ◽  
Angela Pagano ◽  
James A. Rossi-Ashton ◽  
James R. Donald ◽  
Ryan G. Epton ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Visible Light ◽  
Electron Donor ◽  
Intramolecular Charge Transfer ◽  
Thiyl Radical ◽  
Acceptor Complex ◽  
Donor Acceptor ◽  
Radical Generation ◽  
Induced Charge

Indole-tethered ynones form an intramolecular electron donor–acceptor complex that can undergo visible-light-induced charge transfer to promote thiyl radical generation from thiols.

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