Effect of O6-Methylguanine on the Stability of G-Quadruplex DNA

2008 ◽  
Vol 130 (21) ◽  
pp. 6710-6711 ◽  
Author(s):  
Chongkham S. Mekmaysy ◽  
Luigi Petraccone ◽  
Nichola C. Garbett ◽  
Patricia A. Ragazzon ◽  
Robert Gray ◽  
...  
Keyword(s):  
Quadruplex Dna ◽  
G Quadruplex ◽  
The Stability

An in Silico Investigation of Binding Modes and Pathway of APTO-253 on c-KIT G-Quadruplex DNA

2020 ◽  
Author(s):  
Saikat Pal ◽  
Sandip Paul
Keyword(s):  
Cancer Therapy ◽  
In Silico ◽  
Binding Modes ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
The Stability

The stability of c-KIT G-quadruplex DNA by ligands has been a significant concern in the growing field of cancer therapy. Thus, it is very important to understand the mechanism behind...

The effect of interaction between loop bases and ions on the stability of G-quadruplex DNA

2020 ◽  
Author(s):  
Han-Zhen Qiao ◽  
Yuan-Yan Wu ◽  
Yusong Tu ◽  
Cong-Min Ji
Keyword(s):  
Quadruplex Dna ◽  
G Quadruplex ◽  
The Stability

Theoretical Investigation of Conformational Deviation of the Human Parallel Telomeric G-quadruplex DNA in Presence of Different Salt Concentrations and Temperatures Under Confinement

2021 ◽  
Author(s):  
Saikat Pal ◽  
Sandip Paul
Keyword(s):  
Conformational Change ◽  
Theoretical Investigation ◽  
Metal Organic Frameworks ◽  
Water Pool ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Metal Organic ◽  
The Stability

Various experimental reports address the stability of G-quadruplex DNA inside a close confinement such as α-hemolysin, nanocavity water pool and different metal-organic-frameworks (MOFs). To understand the conformational change of G-quadruplex...

Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators

2020 ◽  
Vol 27 (1) ◽  
pp. 154-169 ◽  
Author(s):  
Claudiu N. Lungu ◽  
Bogdan Ionel Bratanovici ◽  
Maria Mirabela Grigore ◽  
Vasilichia Antoci ◽  
Ionel I. Mangalagiu
Keyword(s):  
Experimental Data ◽  
Antimicrobial Properties ◽  
Qsar Model ◽  
Therapeutic Effectiveness ◽  
Computational Results ◽  
Pyridine Derivatives ◽  
Quadruplex Dna ◽  
Dna Intercalators ◽  
Structure Activity ◽  
G Quadruplex

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy

2017 ◽  
Vol 22 (44) ◽  
pp. 6612-6624 ◽  
Author(s):  
Graziella Cimino-Reale ◽  
Nadia Zaffaroni ◽  
Marco Folini
Keyword(s):  
Anticancer Therapy ◽  
Quadruplex Dna ◽  
G Quadruplex
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