Mesoporous Silica Nanospheres as Highly Efficient MRI Contrast Agents

2008 ◽  
Vol 130 (7) ◽  
pp. 2154-2155 ◽  
Author(s):  
Kathryn M. L. Taylor ◽  
Jason S. Kim ◽  
William J. Rieter ◽  
Hongyu An ◽  
Weili Lin ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Silica Nanospheres ◽  
Mri Contrast ◽  
Highly Efficient ◽  
Mesoporous Silica Nanospheres

scholarly journals Multifunctional Mesoporous Silica Nanospheres with Cleavable Gd(III) Chelates as MRI Contrast Agents: Synthesis, Characterization, Target-Specificity, and Renal Clearance

Small ◽  
2011 ◽  
Vol 7 (24) ◽  
pp. 3519-3528 ◽  
Author(s):  
Juan L. Vivero-Escoto ◽  
Kathryn M. L. Taylor-Pashow ◽  
Rachel C. Huxford ◽  
Joseph Della Rocca ◽  
Christie Okoruwa ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Contrast Agents ◽  
Renal Clearance ◽  
Mri Contrast Agents ◽  
Silica Nanospheres ◽  
Target Specificity ◽  
Mri Contrast ◽  
Mesoporous Silica Nanospheres

Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T1/T2 MRI Contrast Agents

2012 ◽  
Vol 124 (36) ◽  
pp. 9253-9256 ◽  
Author(s):  
Thomas Courant ◽  
Valérie Gaëlle Roullin ◽  
Cyril Cadiou ◽  
Maïté Callewaert ◽  
Marie Christine Andry ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Highly Efficient ◽  
T2 Mri

Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T1/T2 MRI Contrast Agents

2012 ◽  
Vol 51 (36) ◽  
pp. 9119-9122 ◽  
Author(s):  
Thomas Courant ◽  
Valérie Gaëlle Roullin ◽  
Cyril Cadiou ◽  
Maïté Callewaert ◽  
Marie Christine Andry ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Highly Efficient ◽  
T2 Mri

Preparation of Highly Efficient MRI Contrast Agents through Complexation of Cationic GdIII-Containing Metallosurfactant with Biocompatible Polyelectrolytes

2014 ◽  
Vol 20 (39) ◽  
pp. 12477-12482 ◽  
Author(s):  
Yingying Chen ◽  
Qin Zhu ◽  
Xinghui Cui ◽  
Weijun Tang ◽  
Heng Yang ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Highly Efficient

scholarly journals Gd/Y Hydroxide Nanosheets as Highly Efficient T1/T2 MRI Contrast Agents

Nanomaterials ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
Xin Li ◽  
Zhenhai Xue ◽  
Jinfeng Xia ◽  
Guohong Zhou ◽  
Danyu Jiang ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Relaxation Times ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Force Microscopy ◽  
Highly Efficient ◽  
Transmission Electron ◽  
Magnetic Resonance Imaging Mri ◽  
Cytotoxicity Assessment ◽  
T2 Mri

To develop highly efficient T1/T2 magnetic resonance imaging (MRI) contrast agents (CAs), Gd/Y hydroxide nanosheets were synthesized by a simple exfoliation method from layer compounds using sodium polyacrylate (PAA) as a dispersant and stabilizer. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) results revealed the excellent performance of monolayer nanosheets with thicknesses of up to 1.5 nm. The MRI results of the T1 and T2 relaxation times showed that all of the Gd/Y hydroxide nanosheets have high longitudinal and transverse relaxivities (r1 and r2). In particular, the 10% Gd-LRH nanosheets exhibited excellent MRI performance (r1 = 103 mM−1 s−1, r2 = 372 mM−1 s−1), which is rarely reported. Based on the relationship between the structure of 10% Gd-LRH nanosheets and their MRI performances, and the highly efficient MRI of spaced Gd atoms in the nanosheets, a special model to explain the outstanding MRI performance of the 10% Gd-LRH nanosheets is suggested. The cytotoxicity assessment of the 10% Gd-LRH nanosheets, evaluated by CCK-8 assays on HeLa cells, indicated no significant cytotoxicity. This study presents a significant advancement in 2D nanomaterial MRI CA research, with Gd-doped nanosheets positioned as highly efficient T1/T2 MRI CA candidates.

High-Throughput Preparation of Hexagonally Ordered Mesoporous Silica and Gadolinosilicate Nanoparticles for use as MRI Contrast Agents

2012 ◽  
Vol 14 (8) ◽  
pp. 443-450 ◽  
Author(s):  
Nicholas M. K. Tse ◽  
Danielle F. Kennedy ◽  
Bradford A. Moffat ◽  
Nigel Kirby ◽  
Rachel A. Caruso ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Contrast Agents ◽  
High Throughput ◽  
Mri Contrast Agents ◽  
Ordered Mesoporous Silica ◽  
Mri Contrast ◽  
Ordered Mesoporous ◽  
Hexagonally Ordered

Generation of Superparamagnetic Liposomes Revealed as Highly Efficient MRI Contrast Agents for in Vivo Imaging

2005 ◽  
Vol 127 (30) ◽  
pp. 10676-10685 ◽  
Author(s):  
Marie-Sophie Martina ◽  
Jean-Paul Fortin ◽  
Christine Ménager ◽  
Olivier Clément ◽  
Gillian Barratt ◽  
...  
Keyword(s):  
Contrast Agents ◽  
In Vivo Imaging ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Highly Efficient
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