scholarly journals 1,3-Dipolar Cycloaddition Reactivities of Perfluorinated Aryl Azides with Enamines and Strained Dipolarophiles

2015 ◽  
Vol 137 (8) ◽  
pp. 2958-2966 ◽  
Author(s):  
Sheng Xie ◽  
Steven A. Lopez ◽  
Olof Ramström ◽  
Mingdi Yan ◽  
K. N. Houk
Keyword(s):  
Dipolar Cycloaddition ◽  
Aryl Azides

Simple, stepwise and alternative syntheses of indolyl triazoles via Huisgen,s 1, 3-dipolar cycloaddition reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Ch. Venkata Ramana Reddy ◽  
G. Ganga Reddy
Keyword(s):  
Reaction Time ◽  
Addition Reaction ◽  
Click Reaction ◽  
Cycloaddition Reaction ◽  
Sodium Ascorbate ◽  
Dipolar Cycloaddition ◽  
Spectroscopic Methods ◽  
Aryl Azides ◽  
Simple Processing ◽  
High Yields

: A series of new 2-((1-((1-(4-methoxy-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)methyl)1H-indol-3-yl)me thylene)malononitrile derivatives were synthesized by the 1,3 dipolar cyclo addition reaction (click reaction) of 2-((1-(prop-2-yn-1-yl)-1H-indol-3-yl)methylene)malononitrile with different aryl azides in the presence of sodium ascorbate and copper sulphate in good yields. The advantages of this method are efficient, clean, high yields, easy workup procedures and shorter reaction time. These reactions are very facile giving products by simple processing that does not require purification by column chromatography. All the newly synthesized compounds were confirmed by spectroscopic methods.

1,3-Dipolar Cycloaddition of Aza-Propargylglycine with Aryl Azides

Synfacts ◽  
2010 ◽  
Vol 2010 (11) ◽  
pp. 1311-1311 ◽  
Author(s):  
W. Lubell ◽  
C. Proulx
Keyword(s):  
Dipolar Cycloaddition ◽  
Aryl Azides

ChemInform Abstract: 1,3-Dipolar Cycloaddition of Aryl Azides to 1-Aryl-3-phenylprop-2-yn-1-ones.

ChemInform ◽  
1989 ◽  
Vol 20 (24) ◽  
Author(s):  
F. A. E. FOULI ◽  
M. E. SHABAN ◽  
E. I. EL-NAGDY ◽  
A. S. A. YOUSSEF
Keyword(s):  
Dipolar Cycloaddition ◽  
Aryl Azides

ChemInform Abstract: Azide-Enolate 1,3-Dipolar Cycloaddition as an Efficient Approach for the Synthesis of 1,5-Disubstituted 1,2,3-Triazoles from Alkyl/Aryl Azides and β-Ketophosphonates.

ChemInform ◽  
2016 ◽  
Vol 47 (25) ◽  
Author(s):  
Davir Gonzalez-Calderon ◽  
Aydee Fuentes-Benites ◽  
Eduardo Diaz-Torres ◽  
Carlos A. Gonzalez-Gonzalez ◽  
Carlos Gonzalez-Romero
Keyword(s):  
Dipolar Cycloaddition ◽  
Aryl Azides ◽  
Alkyl Aryl ◽  
Efficient Approach

scholarly journals Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3249
Author(s):  
Han Luo ◽  
Yong-Feng Lv ◽  
Hong Zhang ◽  
Jiang-Miao Hu ◽  
Hong-Mei Li ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cycloaddition Reaction ◽  
Cancer Cell Lines ◽  
Dipolar Cycloaddition ◽  
Human Cancer Cell ◽  
Aryl Azides ◽  
Human Cancer Cell Lines ◽  
Mcf 7

A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.

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