Enantioselective Construction of Tetrasubstituted Stereogenic Carbons through Brønsted Base Catalyzed Michael Reactions: α′-Hydroxy Enones as Key Enoate Equivalent

2014 ◽  
Vol 136 (51) ◽  
pp. 17869-17881 ◽  
Author(s):  
Eider Badiola ◽  
Béla Fiser ◽  
Enrique Gómez-Bengoa ◽  
Antonia Mielgo ◽  
Iurre Olaizola ◽  
...  
Keyword(s):  
Michael Reactions ◽  
Brønsted Base

Chiral Bicyclic Guanidine as a Versatile Brønsted Base Catalyst for the Enantioselective Michael Reactions of Dithiomalonates and β-Keto Thioesters

2007 ◽  
Vol 349 (16) ◽  
pp. 2454-2458 ◽  
Author(s):  
Weiping Ye ◽  
Zhiyong Jiang ◽  
Yujun Zhao ◽  
Serena Li Min Goh ◽  
Dasheng Leow ◽  
...  
Keyword(s):  
Base Catalyst ◽  
Michael Reactions ◽  
Brønsted Base

Brønsted Base-Catalyzed Tandem Isomerization-Michael Reactions of Alkynes: Synthesis of Oxacycles and Azacycles

2010 ◽  
Vol 352 (18) ◽  
pp. 3373-3379 ◽  
Author(s):  
Hongjun Liu ◽  
Wei Feng ◽  
Choon Wee Kee ◽  
Dasheng Leow ◽  
Wei-Tian Loh ◽  
...  
Keyword(s):  
Michael Reactions ◽  
Brønsted Base

Enantioselective Synthesis of 5,5-Disubstituted Hydantoins by Brønsted Base/H-Bond Catalyst Assisted Michael Reactions of a Design Template

2018 ◽  
Vol 24 (28) ◽  
pp. 7217-7227 ◽  
Author(s):  
Joseba Izquierdo ◽  
Julen Etxabe ◽  
Eider Duñabeitia ◽  
Aitor Landa ◽  
Mikel Oiarbide ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Michael Reactions ◽  
Brønsted Base

Enantioselective Michael Addition of Malonates to Enones

2020 ◽  
Vol 24 (7) ◽  
pp. 746-773
Author(s):  
Péter Bakó ◽  
Tamás Nemcsok ◽  
Zsolt Rapi ◽  
György Keglevich
Keyword(s):  
Michael Addition ◽  
Activity Relationship ◽  
Chalcone Derivatives ◽  
Michael Additions ◽  
Michael Reactions ◽  
Structure Activity ◽  
Cyclic Enones ◽  
Michael Acceptors ◽  
Relationship Of ◽  
Enantioselective Catalysts

: Many catalysts were tested in asymmetric Michael additions in order to synthesize enantioenriched products. One of the most common reaction types among the Michael reactions is the conjugated addition of malonates to enones making it possible to investigate the structure–activity relationship of the catalysts. The most commonly used Michael acceptors are chalcone, substituted chalcones, chalcone derivatives, cyclic enones, while typical donors may be dimethyl, diethyl, dipropyl, diisopropyl, dibutyl, di-tert-butyl and dibenzyl malonates. This review summarizes the most important enantioselective catalysts applied in these types of reactions.

scholarly journals Synthesis and Catalytic Activities of 3-Decyl-β-proline for Michael Reactions in Water without an Organic Solvent

ACS Omega ◽  
2021 ◽  
Author(s):  
Kazuhiro Nagata ◽  
Chihiro Nakagawa ◽  
Wakana Yokoyama ◽  
Haruka Usui ◽  
Rikako Mochizuki ◽  
...  
Keyword(s):  
Organic Solvent ◽  
Catalytic Activities ◽  
Michael Reactions

Boric acid catalyzed thia-Michael reactions in water or alcohols

2007 ◽  
Vol 269 (1-2) ◽  
pp. 214-217 ◽  
Author(s):  
Mihir K. Chaudhuri ◽  
Sahid Hussain
Keyword(s):  
Boric Acid ◽  
Michael Reactions ◽  
Acid Catalyzed
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