Stimuli-Responsive Conformational Conversion of Peptide Gatekeepers for Controlled Release of Guests from Mesoporous Silica Nanocontainers

2014 ◽  
Vol 136 (37) ◽  
pp. 12880-12883 ◽  
Author(s):  
Jeonghun Lee ◽  
Hyunmi Kim ◽  
Songyi Han ◽  
Eunjung Hong ◽  
Keun-Hyeung Lee ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Stimuli Responsive ◽  
Conformational Conversion

Stimuli-Responsive Controlled-Release Delivery System Based on Mesoporous Silica Nanorods Capped with Magnetic Nanoparticles

2005 ◽  
Vol 117 (32) ◽  
pp. 5166-5172 ◽  
Author(s):  
Supratim Giri ◽  
Brian G. Trewyn ◽  
Michael P. Stellmaker ◽  
Victor S.-Y. Lin
Keyword(s):  
Magnetic Nanoparticles ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Silica Nanorods

Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles

2015 ◽  
Vol 44 (9) ◽  
pp. 4355-4361 ◽  
Author(s):  
Yu Xiao ◽  
Tao Wang ◽  
Yu Cao ◽  
Xue Wang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Release System ◽  
Controlled Release System

This work demonstrated the development of a novel controlled release system, which is sensitive to enzyme and voltage stimuli, based on mesoporous silica nanoparticles functionalized by a ferrocene moiety with β-cyclodextrin as the nanovalve.

Stimuli-responsive α-helical peptide gatekeepers for mesoporous silica nanocarriers

2017 ◽  
Vol 41 (15) ◽  
pp. 6969-6972 ◽  
Author(s):  
Jeonghun Lee ◽  
Seungjong Han ◽  
Jinyoung Lee ◽  
Minhyuek Choi ◽  
Chulhee Kim
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Lipid Membranes ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Helical Peptide ◽  
Conformational Conversion

A stimuli-responsive α-helical peptide, as a gatekeeper on the surface of mesoporous silica nanoparticles, efficiently controlled the release of entrapped drugs through triggered conformational conversion and effectively disrupted lipid membranes.

Smart mesoporous silica nanoparticles for controlled-release drug delivery

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Mahdi Karimi ◽  
Hamed Mirshekari ◽  
Masoumeh Aliakbari ◽  
Parham Sahandi-Zangabad ◽  
Michael R. Hamblin
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Capacity ◽  
Bioactive Molecules ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Stimulus Responsive ◽  
External Stimuli

AbstractStimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular “gatekeepers” or “nanovalves.” In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.

Temperature and ultrasound sensitive gatekeepers for the controlled release of chemotherapeutic drugs from mesoporous silica nanoparticles

2018 ◽  
Vol 6 (3) ◽  
pp. 428-439 ◽  
Author(s):  
T. S. Anirudhan ◽  
Anoop S. Nair
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Transdermal Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Chemotherapeutic Drugs ◽  
Stimuli Responsive ◽  
Internal Organs ◽  
Delivery Route

The copolymer chains were grafted onto the mesopores of silica nanoparticles and could act as stimuli responsive ‘smart’ gatekeepers. With the aid of a transdermal delivery route and ultrasound penetration, even malignant sites of internal organs can be set as targets.

scholarly journals Correction: Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles

2015 ◽  
Vol 44 (17) ◽  
pp. 8300-8300 ◽  
Author(s):  
Yu Xiao ◽  
Tao Wang ◽  
Yu Cao ◽  
Xue Wang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Dalton Trans ◽  
Release System ◽  
Controlled Release System

Correction for ‘Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles’ by Yu Xiao et al., Dalton Trans., 2015, 44, 4355–4361.

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