Extended String Binding Mode of the Phosphorylated Transactivation Domain of Tumor Suppressor p53

2014 ◽  
Vol 136 (40) ◽  
pp. 14143-14152 ◽  
Author(s):  
Masahiko Okuda ◽  
Yoshifumi Nishimura
Keyword(s):  
Tumor Suppressor ◽  
Binding Mode ◽  
Transactivation Domain ◽  
Tumor Suppressor P53

scholarly journals Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

2008 ◽  
Vol 105 (15) ◽  
pp. 5762-5767 ◽  
Author(s):  
M. Wells ◽  
H. Tidow ◽  
T. J. Rutherford ◽  
P. Markwick ◽  
M. R. Jensen ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Transactivation Domain ◽  
Tumor Suppressor P53 ◽  
Intrinsically Disordered

Chemical Synthesis of the Multiply Phosphorylated and Biotinylated N-Terminal Transactivation Domain of Human p53 (p53TAD)

Synlett ◽  
2017 ◽  
Vol 28 (15) ◽  
pp. 1917-1922 ◽  
Author(s):  
Zhongping Tan ◽  
Xiaoyang Guan ◽  
Patrick Chaffey ◽  
Yuan Ruan ◽  
Connor Hurd ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Chemical Synthesis ◽  
Native Chemical Ligation ◽  
Methionine Oxidation ◽  
Phosphorylation Sites ◽  
Transactivation Domain ◽  
Biological Functions ◽  
Tumor Suppressor P53 ◽  
Chemical Ligation ◽  
Metal Free

Phosphorylation of the N-terminal transactivation domain (TAD) of tumor suppressor p53 (p53TAD) helps regulate many of p53’s biological functions. Chemical synthesis of the p53TAD sequence with various phosphorylation patterns, through native chemical ligation and metal-free desulfurization, would facilitate studies of p53TAD phosphorylation and its role in regulating p53 function. Here, unphosphorylated, mono- and pentaphosphorylated p53TAD constructs were chemically synthesized. During the synthesis, methionine oxidation was found to be a serious problem and reduction was required at different stages, according to the number of phosphorylation sites.

Dense Liquid Condensates Host the Nucleation of Tumor Suppressor p53 Fibrils

2018 ◽  
Author(s):  
Mohammad S. Safari ◽  
Zhiqing Wang ◽  
Kunaal Tailor ◽  
Anatoly B. Kolomeisky ◽  
Jacinta C. Conrad ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor P53 ◽  
Dense Liquid

The Sumoylation Modulated Tumor Suppressor p53 Regulates Cell Cycle Checking Genes to Mediate Lens Differentiation

2019 ◽  
Vol 18 (8) ◽  
pp. 556-565 ◽  
Author(s):  
Xiangcheng Tang ◽  
Zhigang Chen ◽  
Mi Deng ◽  
Ling Wang ◽  
Qian Nie ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Suppressor ◽  
Tumor Suppressor P53

p22/PACAP Response Gene 1 (PRG1): A Putative Target Gene for the Tumor Suppressor p53

1998 ◽  
Vol 865 (1 VIP, PACAP, A) ◽  
pp. 27-36 ◽  
Author(s):  
HEINER SCHAFER ◽  
ANNA TRAUZOLD ◽  
THORSTEN SEBENS ◽  
WOLFGANG DEPPERT ◽  
ULRICH R. FOLSCH ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Target Gene ◽  
Tumor Suppressor P53 ◽  
Putative Target Gene ◽  
Response Gene ◽  
Putative Target
Sign in / Sign up

Export Citation Format

Share Document