Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation

2014 ◽  
Vol 136 (27) ◽  
pp. 9701-9709 ◽  
Author(s):  
Jianan Liu ◽  
Yong Liu ◽  
Wenbo Bu ◽  
Jiwen Bu ◽  
Yong Sun ◽  
...  
Keyword(s):  
Near Infrared ◽  
Upconversion Nanoparticles ◽  
Hypoxia Imaging ◽  
Infrared Excitation

Quasi-Continuous Wave Near-Infrared Excitation of Upconversion Nanoparticles for Optogenetic Manipulation ofC. elegans

Small ◽  
2016 ◽  
Vol 12 (13) ◽  
pp. 1732-1743 ◽  
Author(s):  
Akshaya Bansal ◽  
Haichun Liu ◽  
Muthu Kumara Gnanasammandhan Jayakumar ◽  
Stefan Andersson-Engels ◽  
Yong Zhang
Keyword(s):  
Near Infrared ◽  
Continuous Wave ◽  
Upconversion Nanoparticles ◽  
Infrared Excitation

A new near-infrared excitation PDT photosensitizer in vivo

2021 ◽  
Author(s):  
Yueshu Feng ◽  
Binyu Li ◽  
Yulin Huang
Keyword(s):  
Near Infrared ◽  
Infrared Excitation

Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation

2019 ◽  
Vol 7 (46) ◽  
pp. 7306-7313 ◽  
Author(s):  
Jinhua Wu ◽  
Shanshan Du ◽  
Yuhua Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Rare Earth ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Great Promise ◽  
Upconversion Nanoparticles ◽  
Oxygen Species ◽  
Infrared Excitation

Rare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT).

In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe

2016 ◽  
Vol 254 (12) ◽  
pp. 2373-2385 ◽  
Author(s):  
Shinichi Fukuda ◽  
Kensuke Okuda ◽  
Genichiro Kishino ◽  
Sujin Hoshi ◽  
Itsuki Kawano ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Hypoxia Imaging

scholarly journals Upconversion Nanoparticles Decorated with Polysialic Acid for Solid Tumors Visualization In Vivo

2021 ◽  
Author(s):  
P. A. Demina ◽  
N. V. Sholina ◽  
R. A. Akasov ◽  
D. A. Khochenkov ◽  
A. V. Nechaev ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Near Infrared ◽  
Signal To Noise Ratio ◽  
Polysialic Acid ◽  
Lymphatic Drainage ◽  
Circulation Time ◽  
High Signal ◽  
Upconversion Nanoparticles ◽  
Nonspecific Protein Adsorption

Abstract Upconversion nanoparticles (UCNPs) are a promising nanoplatform for bioreagent formation for in vivo imaging, which emit UV and blue light under the action of near-infrared radiation, providing deep tissue penetration and maintaining a high signal-to-noise ratio. In the case of solid tumor visualization, the UCNP surface functionalization is required to ensure a long circulation time, biocompatibility, and non-toxicity. The effective UCNP accumulation in the solid tumors is determined by the disturbed architecture of the vascular network and lymphatic drainage. This work demonstrates an approach to the UCNP biofunctionalization with endogenous polysialic acid for in vivo bioreagent formation. Bioreagents possess a low level of nonspecific protein adsorption and macrophage uptake, which allow the prolongation of the circulation time in the bloodstream up to 3 h. This leads to an intense photoluminescent signal in the tumor.

scholarly journals Nanocurcumin-Loaded UCNPs for Cancer Theranostics: Physicochemical Properties, In Vitro Toxicity, and In Vivo Imaging Studies

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2234
Author(s):  
Anbharasi Lakshmanan ◽  
Roman A. Akasov ◽  
Natalya V. Sholina ◽  
Polina A. Demina ◽  
Alla N. Generalova ◽  
...  
Keyword(s):  
Near Infrared ◽  
Therapeutic Potential ◽  
Ex Vivo ◽  
Laboratory Animals ◽  
In Vitro Toxicity ◽  
Upconversion Nanoparticles ◽  
Lewis Lung Cancer ◽  
Spectral Bands

Formulation of promising anticancer herbal drug curcumin as a nanoscale-sized curcumin (nanocurcumin) improved its delivery to cells and organisms both in vitro and in vivo. We report on coupling nanocurcumin with upconversion nanoparticles (UCNPs) using Poly (lactic-co-glycolic Acid) (PLGA) to endow visualisation in the near-infrared transparency window. Nanocurcumin was prepared by solvent-antisolvent method. NaYF4:Yb,Er (UCNP1) and NaYF4:Yb,Tm (UCNP2) nanoparticles were synthesised by reverse microemulsion method and then functionalized it with PLGA to form UCNP-PLGA nanocarrier followed up by loading with the solvent-antisolvent process synthesized herbal nanocurcumin. The UCNP samples were extensively characterised with XRD, Raman, FTIR, DSC, TGA, UV-VIS-NIR spectrophotometer, Upconversion spectrofluorometer, HRSEM, EDAX and Zeta Potential analyses. UCNP1-PLGA-nanocurcumin exhibited emission at 520, 540, 660 nm and UCNP2-PLGA-nanocurmin showed emission at 480 and 800 nm spectral bands. UCNP-PLGA-nanocurcumin incubated with rat glioblastoma cells demonstrated moderate cytotoxicity, 60–80% cell viability at 0.12–0.02 mg/mL marginally suitable for therapeutic applications. The cytotoxicity of UCNPs evaluated in tumour spheroids models confirmed UCNP-PLGA-nanocurcumin therapeutic potential. As-synthesised curcumin-loaded nanocomplexes were administered in tumour-bearing laboratory animals (Lewis lung cancer model) and showed adequate contrast to enable in vivo and ex vivo study of UCNP-PLGA-nanocurcumin bio distribution in organs, with dominant distribution in the liver and lungs. Our studies demonstrate promise of nanocurcumin-loaded upconversion nanoparticles for theranostics applications.

A new near-infrared excitation/emission fluorescent probe for the detection of β-galactosidase in living cells and in vivo

Talanta ◽  
2022 ◽  
Vol 237 ◽  
pp. 122952
Author(s):  
Yin Li ◽  
Feiyan Liu ◽  
Dongrong Zhu ◽  
Tianyu Zhu ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Infrared Excitation

scholarly journals Hyaluronate modified upconversion nanoparticles for near infrared light-triggered on–off tattoo systems

RSC Advances ◽  
2017 ◽  
Vol 7 (24) ◽  
pp. 14805-14808 ◽  
Author(s):  
Seulgi Han ◽  
Songeun Beack ◽  
Sanghwa Jeong ◽  
Byung Woo Hwang ◽  
Myeong Hwan Shin ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light

We successfully developed an NIR light-triggered in vivo on–off tattoo system using hyaluronate modified upconversion nanoparticles for various biomedical applications.

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