Thermal Gating in Lipid Membranes Using Thermoresponsive Cyclic Peptide–Polymer Conjugates

2014 ◽  
Vol 136 (22) ◽  
pp. 8018-8026 ◽  
Author(s):  
Maarten Danial ◽  
Carmen M.-N. Tran ◽  
Katrina A. Jolliffe ◽  
Sébastien Perrier
Keyword(s):  
Lipid Membranes ◽  
Cyclic Peptide ◽  
Polymer Conjugates

Hierarchical Assembly of Branched Supramolecular Polymers from (Cyclic Peptide)–Polymer Conjugates

2014 ◽  
Vol 15 (11) ◽  
pp. 4002-4011 ◽  
Author(s):  
Ming Liang Koh ◽  
Katrina A. Jolliffe ◽  
Sébastien Perrier
Keyword(s):  
Cyclic Peptide ◽  
Supramolecular Polymers ◽  
Hierarchical Assembly ◽  
Polymer Conjugates

scholarly journals Diastereoisomeric analogues of gramicidin S: structure, biological activity and interaction with lipid bilayers

2000 ◽  
Vol 349 (3) ◽  
pp. 747-755 ◽  
Author(s):  
Masood JELOKHANI-NIARAKI ◽  
Leslie H. KONDEJEWSKI ◽  
Susan W. FARMER ◽  
Robert E. W. HANCOCK ◽  
Cyril M. KAY ◽  
...  
Keyword(s):  
Biological Activity ◽  
Lipid Bilayers ◽  
Lipid Membranes ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Cd Spectra ◽  
Gramicidin S ◽  
Sds Micelles ◽  
Related Approach ◽  
Relationship Of

Analogues of a structurally equivalent version of the antimicrobial decameric cyclic peptide gramicidin S, GS10 [cyclo-(Val-Lys-Leu-D-Tyr-Pro)2], were designed to study the effect of distortion in the β-sheet/β-turn structure of the cyclic peptide on its biological activity. In one approach, the hydrophobic nature of GS10 was conserved, and single amino acids in its backbone were replaced systematically with their corresponding enantiomers to give five diastereoisomeric analogues. In a related approach, a more basic and hydrophilic analogue of GS10 [cyclo-(Lys-Val-Lys-D-Tyr-Pro5-Lys-Leu-Lys-D-Tyr-Pro10)], together with two of its monosubstituted diastereoisomeric analogues (featuring D-Lys1 or D-Val2 respectively), were synthesized. CD spectra were measured in a variety of environments, i.e. aqueous, aqueous trifluoroethanol and those containing SDS micelles or phospholipid vesicles. In comparison with GS10 spectra, CD spectra of both groups of analogues in these environments exhibited structural distortion. Moreover, compared with GS10, antimicrobial and haemolytic activities of the analogues were drastically decreased, implying the existence of a threshold minimum amphipathicity for effective biological activity. However, in both groups of analogues, there was a correlation between amphipathicity and antimicrobial and haemolytic activities. In the second group of analogues, both electrostatic and hydrophobic factors were related to their antimicrobial and haemolytic activities. In order to gain an insight into the nature of the biological activity of the two classes of cyclic peptides, the relationship of their structure to interaction with lipid membranes, and the implied mechanisms, were analysed in some detail in the present study.

Oriented Self-Assembly of Cyclic Peptide Nanotubes in Lipid Membranes

1998 ◽  
Vol 120 (18) ◽  
pp. 4417-4424 ◽  
Author(s):  
Hui Sun Kim ◽  
Jeffrey D. Hartgerink ◽  
M. Reza Ghadiri
Keyword(s):  
Self Assembly ◽  
Lipid Membranes ◽  
Cyclic Peptide ◽  
Peptide Nanotubes ◽  
Cyclic Peptide Nanotubes

scholarly journals Tubular Supramolecular Alternating Copolymers Fabricated by Cyclic Peptide–Polymer Conjugates

2021 ◽  
Author(s):  
Qiao Song ◽  
Andrew Kerr ◽  
Jie Yang ◽  
Stephen Hall ◽  
Sebastien Perrier
Keyword(s):  
Cyclic Peptide ◽  
Noncovalent Interactions ◽  
Polymer Conjugates ◽  
Alternating Copolymers ◽  
Multiple Components

Supramolecular copolymers are an emerging class of materials, which bring together different properties and functionalities of multiple components via noncovalent interactions. While it is widely acknowledged that the repeating unit...

scholarly journals Pyridyl Disulfide Reaction Chemistry: An Efficient Strategy toward Redox-Responsive Cyclic Peptide–Polymer Conjugates

2019 ◽  
Vol 8 (10) ◽  
pp. 1347-1352 ◽  
Author(s):  
Qiao Song ◽  
Jie Yang ◽  
Stephen C. L. Hall ◽  
Pratik Gurnani ◽  
Sébastien Perrier
Keyword(s):  
Cyclic Peptide ◽  
Efficient Strategy ◽  
Polymer Conjugates ◽  
Redox Responsive

Synthesis of cyclic peptide disulfide–PHPMA conjugates via sequential active ester aminolysis and CuAAC coupling

2016 ◽  
Vol 7 (4) ◽  
pp. 970-978 ◽  
Author(s):  
Kemal Arda Günay ◽  
Harm-Anton Klok
Keyword(s):  
Cyclic Peptide ◽  
Protecting Groups ◽  
Polymer Conjugates ◽  
Synthetic Strategy ◽  
Active Ester ◽  
Ester Aminolysis

A synthetic strategy for the preparation of cyclic peptide disulfide–polymer conjugates that does not require peptide protecting groups is reported.

Cyclic peptide-polymer conjugates: Grafting-to vs grafting-from

2015 ◽  
Vol 54 (7) ◽  
pp. 1003-1011 ◽  
Author(s):  
Sophie C. Larnaudie ◽  
Johannes C. Brendel ◽  
Katrina A. Jolliffe ◽  
Sébastien Perrier
Keyword(s):  
Cyclic Peptide ◽  
Polymer Conjugates ◽  
Grafting From

scholarly journals Stimuli-responsive membrane activity of cyclic-peptide–polymer conjugates

2019 ◽  
Vol 10 (21) ◽  
pp. 5476-5483 ◽  
Author(s):  
Matthias Hartlieb ◽  
Sylvain Catrouillet ◽  
Agnès Kuroki ◽  
Carlos Sanchez-Cano ◽  
Raoul Peltier ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Stimuli Responsive ◽  
Peptide Nanotubes ◽  
Membrane Activity ◽  
Polymer Conjugates ◽  
On Demand ◽  
Cyclic Peptide Nanotubes

Cyclic peptide nanotubes were coupled to poly(oxazoline)s using a cleavable connection. Upon stimuli responsive detachment of the polymer an on-demand membrane activity could be achieved.

scholarly journals pH-Responsive, Amphiphilic Core–Shell Supramolecular Polymer Brushes from Cyclic Peptide–Polymer Conjugates

2017 ◽  
Vol 6 (12) ◽  
pp. 1347-1351 ◽  
Author(s):  
Sophie C. Larnaudie ◽  
Johannes C. Brendel ◽  
Katrina A. Jolliffe ◽  
Sébastien Perrier
Keyword(s):  
Polymer Brushes ◽  
Cyclic Peptide ◽  
Supramolecular Polymer ◽  
Core Shell ◽  
Ph Responsive ◽  
Polymer Conjugates

scholarly journals Supramolecular switching of the self-assembly of cyclic peptide–polymer conjugates via host–guest chemistry

2019 ◽  
Vol 55 (36) ◽  
pp. 5291-5294 ◽  
Author(s):  
Qiao Song ◽  
Jie Yang ◽  
Julia Y. Rho ◽  
Sébastien Perrier
Keyword(s):  
Self Assembly ◽  
Cyclic Peptide ◽  
The Self ◽  
Polymer Conjugates ◽  
Guest Chemistry

A supramolecular strategy of switching the self-assembly of cyclic peptide–polymer conjugates using host–guest chemistry is proposed.

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