Structurally Defined Nanoscale Sheets from Self-Assembly of Collagen-Mimetic Peptides

2014 ◽  
Vol 136 (11) ◽  
pp. 4300-4308 ◽  
Author(s):  
Tao Jiang ◽  
Chunfu Xu ◽  
Yang Liu ◽  
Zheng Liu ◽  
Joseph S. Wall ◽  
...  
Keyword(s):  
Self Assembly ◽  
Mimetic Peptides ◽  
Collagen Mimetic Peptides

scholarly journals Supramolecular Nanofibers from Collagen-Mimetic Peptides Bearing Various Aromatic Groups at N-Termini via Hierarchical Self-Assembly

2021 ◽  
Vol 22 (9) ◽  
pp. 4533
Author(s):  
Tomoyuki Koga ◽  
Shinya Kingetsu ◽  
Nobuyuki Higashi
Keyword(s):  
Self Assembly ◽  
Triple Helix ◽  
Wavelength Conversion ◽  
Nile Red ◽  
Tem Analysis ◽  
Mimetic Peptides ◽  
Collagen Mimetic Peptides ◽  
Potential Applications ◽  
Hydrophobic Molecule ◽  
Emission Behavior

Self-assembly of artificial peptides has been widely studied for constructing nanostructured materials, with numerous potential applications in the nanobiotechnology field. Herein, we report the synthesis and hierarchical self-assembly of collagen-mimetic peptides (CMPs) bearing various aromatic groups at the N-termini, including 2-naphthyl, 1-naphtyl, anthracenyl, and pyrenyl groups, into nanofibers. The CMPs (R-(GPO)n: n > 4) formed a triple helix structure in water at 4 °C, as confirmed via CD analyses, and their conformations were more stable with increasing hydrophobicity of the terminal aromatic group and peptide chain length. The resulting pre-organized triple helical CMPs showed diverse self-assembly into highly ordered nanofibers, reflecting their slight differences in hydrophobic/hydrophilic balance and configuration of aromatic templates. TEM analysis demonstrated that 2Np-CMPn (n = 6 and 7) and Py-CMP6 provided well-developed natural collagen-like nanofibers and An-CMPn (n = 5–7) self-assembled into rod-like micelle fibers. On the other hand, 2Np-CMP5 and 1Np-CMP6 were unable to form nanofibers under the same conditions. Furthermore, the Py-CMP6 nanofiber was found to encapsulate a guest hydrophobic molecule, Nile red, and exhibited unique emission behavior based on the specific nanostructure. In addition to the ability of CMPs to bind small molecules, their controlled self-assembly enables their versatile utilization in drug delivery and wavelength-conversion nanomaterials.

scholarly journals Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions

2008 ◽  
Vol 105 (25) ◽  
pp. 8513-8518 ◽  
Author(s):  
M. A. Cejas ◽  
W. A. Kinney ◽  
C. Chen ◽  
J. G. Vinter ◽  
H. R. Almond ◽  
...  
Keyword(s):  
Self Assembly ◽  
Triple Helix ◽  
Hydrophobic Interactions ◽  
Mimetic Peptides ◽  
Collagen Mimetic Peptides

Self-Assembly of Fiber-Forming Collagen Mimetic Peptides Controlled by Triple-Helical Nucleation

2014 ◽  
Vol 136 (41) ◽  
pp. 14417-14424 ◽  
Author(s):  
Biplab Sarkar ◽  
Lesley E. R. O’Leary ◽  
Jeffrey D. Hartgerink
Keyword(s):  
Self Assembly ◽  
Mimetic Peptides ◽  
Collagen Mimetic Peptides

scholarly journals Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation

2020 ◽  
Vol 8 ◽  
Author(s):  
Andrew T. Rowley ◽  
Vijaykumar S. Meli ◽  
Natalie J. Wu-Woods ◽  
Esther Y. Chen ◽  
Wendy F. Liu ◽  
...  
Keyword(s):  
Mimetic Peptides ◽  
Collagen Mimetic Peptides ◽  
Macrophage Uptake

scholarly journals Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions

2017 ◽  
Vol 15 (28) ◽  
pp. 5893-5898 ◽  
Author(s):  
Kenneth McGuinness ◽  
Vikas Nanda
Keyword(s):  
Hydrophobic Interactions ◽  
Mimetic Peptide ◽  
Natural Protein ◽  
Protein Fibers ◽  
Mimetic Peptides ◽  
Collagen Mimetic Peptides

Collagen mimetic peptides bind to a variety of fiber-forming proteins through complementary hydrophobic interactions, resulting in discs-on-a-string nanostructures and bundling of fibers.

A CMP-based method for tunable, cell-mediated gene delivery from collagen scaffolds

2014 ◽  
Vol 2 (46) ◽  
pp. 8174-8185 ◽  
Author(s):  
M. A. Urello ◽  
K. L. Kiick ◽  
M. O. Sullivan
Keyword(s):  
Gene Delivery ◽  
Collagen Scaffolds ◽  
Mimetic Peptides ◽  
Collagen Mimetic Peptides

Collagen mimetic peptides (CMP)s were used to tailor release vs. retention of DNA polyplexes from collagen while preserving polyplex activity.

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