Photoinduced Electron Transfer of DNA/Ag Nanoclusters Modulated by G-Quadruplex/Hemin Complex for the Construction of Versatile Biosensors

2013 ◽  
Vol 135 (7) ◽  
pp. 2403-2406 ◽  
Author(s):  
Libing Zhang ◽  
Jinbo Zhu ◽  
Shaojun Guo ◽  
Tao Li ◽  
Jing Li ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Photoinduced Electron Transfer ◽  
G Quadruplex ◽  
Ag Nanoclusters

Rational design of signal-on biosensors by using photoinduced electron transfer between Ag nanoclusters and split G-quadruplex halves–hemin complexes

2014 ◽  
Vol 50 (91) ◽  
pp. 14221-14224 ◽  
Author(s):  
Kai Zhang ◽  
Ke Wang ◽  
Xue Zhu ◽  
Yun Gao ◽  
Minhao Xie
Keyword(s):  
Electron Transfer ◽  
Photoinduced Electron Transfer ◽  
Rational Design ◽  
Sensing Platform ◽  
G Quadruplex ◽  
Ag Nanoclusters

Photoinduced electron transfer (PET) between DNA–Ag nanoclusters (AgNCs) and G-quadruplex halves–hemin has been used for building a new sensing platform for the signal-on detection of adenosine and RNA.

A photoelectrochemical sensor through quenching of photoinduced electrons based on a G-quadruplex/hemin complex

2015 ◽  
Vol 7 (9) ◽  
pp. 3697-3700 ◽  
Author(s):  
Xiang Yan ◽  
Kewei Wang ◽  
Danping Xie ◽  
Lijun Xu ◽  
Qianqian Han ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Photoinduced Electron Transfer ◽  
Label Free ◽  
Withdrawal Effect ◽  
Photoelectrochemical Sensor ◽  
G Quadruplex ◽  
Electron Withdrawal

A novel label-free photoelectrochemical sensor was fabricated for the detection of K+ based on the electron withdrawal effect of hemin. The decreasing photocurrent from photoinduced electron transfer by a G-quadruplex/hemin complex was utilized.

A fluorescent signal-on sensor based on photoinduced electron transfer between copper nanoparticles and G-quadruplex/hemin

2019 ◽  
Vol 11 (18) ◽  
pp. 2410-2414
Author(s):  
Li Juan Ou ◽  
Si Wen Qin ◽  
Heng Bo ◽  
Jian Xin Luo ◽  
Ni Cui Yuan ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Copper Nanoparticles ◽  
Photoinduced Electron Transfer ◽  
Fluorescence Signal ◽  
Copper Nanoclusters ◽  
Fluorescent Signal ◽  
G Quadruplex

A novel fluorescence signal-on biosensing platform was developed by using photoinduced electron transfer (PET) between copper nanoclusters (CuNCs) and G-quadruplex/hemin.

scholarly journals Topology-Selective, Fluorescent “Light-Up” Probes for G-Quadruplex DNA Based on Photoinduced Electron Transfer

2018 ◽  
Vol 24 (48) ◽  
pp. 12638-12651 ◽  
Author(s):  
Xiao Xie ◽  
Oksana Reznichenko ◽  
Ludovic Chaput ◽  
Pascal Martin ◽  
Marie-Paule Teulade-Fichou ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Photoinduced Electron Transfer ◽  
Fluorescent Light ◽  
Quadruplex Dna ◽  
G Quadruplex

Computationally Assisted Design of High Signal-to-Noise Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes

2020 ◽  
Author(s):  
Rishikesh Kulkarni ◽  
Anneliese Gest ◽  
Chun Kei Lam ◽  
Benjamin Raliski ◽  
Feroz James ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Dft Calculations ◽  
Photoinduced Electron Transfer ◽  
Density Functional ◽  
Embryonic Stem ◽  
High Sensitivity ◽  
Md Simulations ◽  
High Signal ◽  
Signal To Noise ◽  
Green Fluorescent

<p>High signal-to-noise optical voltage indicators will enable simultaneous interrogation of membrane potential in large ensembles of neurons. However, design principles for voltage sensors with high sensitivity and brightness remain elusive, limiting the applicability of voltage imaging. In this paper, we use molecular dynamics (MD) simulations and density functional theory (DFT) calculations to guide the design of a bright and sensitive green-fluorescent voltage-sensitive fluorophore, or VoltageFluor (VF dye), that uses photoinduced electron transfer (PeT) as a voltage-sensing mechanism. MD simulations predict an 11% increase in sensitivity due to membrane orientation, while DFT calculations predict an increase in fluorescence quantum yield, but a decrease in sensitivity due to a decrease in rate of PeT. We confirm these predictions by synthesizing a new VF dye and demonstrating that it displays the expected improvements by doubling the brightness and retaining similar sensitivity to prior VF dyes. Combining theoretical predictions and experimental validation has resulted in the synthesis of the highest signal-to-noise green VF dye to date. We use this new voltage indicator to monitor the electrophysiological maturation of human embryonic stem cell-derived medium spiny neurons. </p>

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