“Donor–Two-Acceptor” Dye Design: A Distinct Gateway to NIR Fluorescence

2012 ◽  
Vol 134 (50) ◽  
pp. 20412-20420 ◽  
Author(s):  
Naama Karton-Lifshin ◽  
Lorenzo Albertazzi ◽  
Michael Bendikov ◽  
Phil S. Baran ◽  
Doron Shabat
Keyword(s):  
Nir Fluorescence

Infrared fluorescence lymphography in experimental and clinical practice

2018 ◽  
Vol 17 (2) ◽  
pp. 84-91 ◽  
Author(s):  
G. V. Papayan ◽  
A. L. Akopov ◽  
P. A. Antonyan ◽  
A. A. Ilin ◽  
N. N. Petrishchev
Keyword(s):  
Lymph Nodes ◽  
Near Infrared ◽  
Lymphatic System ◽  
Lymphatic Vessels ◽  
Diagnostic System ◽  
Biological Tissues ◽  
Peritumoral Injection ◽  
Intradermal Administration ◽  
Nir Fluorescence ◽  
Real Time Visualization

Introduction. Near infrared (NIR) fluorescent diagnostics is promising due to a deeper penetration into biological tissues. Material and methods. In experiments on rabbits and in clinical studies evaluation the lymphatic system with the use of the instrument complex FLUM-808 was analysed. Results. For visualization of the lymphatic vessels of the skin, the intradermal administration of ICG, dissolved in 20 % albumin in the order of 0.02 mg/ml, is optimal. Peritumoral injection of ICG allows visualizing sentinel lymph nodes in patients with lung cancer. Conclusions. The developed NIR fluorescence diagnostic system FLUM-808 allows to real time visualization of lymphatic vessels and lymph nodes.

N-(5-Amino-9H-benzo[a]phenoxazin-9-ylidene)propan-1-aminium chlorides as antifungal agents and NIR fluorescence probes

2021 ◽  
Author(s):  
Rui P. C. L. Sousa ◽  
João C. C. Ferreira ◽  
Maria João Sousa ◽  
M Sameiro Sameiro T T Gonçalves
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agents ◽  
Nile Blue ◽  
Fluorescence Probes ◽  
Cell Labelling ◽  
Nir Fluorescence ◽  
High Antifungal Activity

The search for benzo[a]phenoxazines, Nile Blue derivatives, with high antifungal activity and cell labelling capacity based on our previously published works in this type of compounds, led us to the...

Ultrasensitive NIR fluorescence detection and its application to the analysis of DNA

1993 ◽  
Author(s):  
Steven A. Soper ◽  
Quincy L. Mattingly ◽  
Benjamin L. Legendre, Jr. ◽  
Daryl Williams ◽  
James H. Flanagan, Jr. ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Nir Fluorescence

Near-infrared fluorescence imaging with indocyanine green for quantification of changes in tissue perfusion following revascularization

Vascular ◽  
2021 ◽  
pp. 170853812110328
Author(s):  
Pim Van den Hoven ◽  
Floris S Weller ◽  
Merel Van De Bent ◽  
Lauren N Goncalves ◽  
Melissa Ruig ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Fluorescence Intensity ◽  
Near Infrared ◽  
Tissue Perfusion ◽  
Control Group ◽  
Maximum Slope ◽  
Nir Fluorescence ◽  
Significant Difference ◽  
Revascularization Procedures

Objectives Current diagnostic modalities for patients with peripheral artery disease (PAD) mainly focus on the macrovascular level. For assessment of tissue perfusion, near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) seems promising. In this prospective cohort study, ICG NIR fluorescence imaging was performed pre- and post-revascularization to assess changes in foot perfusion. Methods ICG NIR fluorescence imaging was performed in 36 patients with PAD pre- and post-intervention. After intravenous bolus injection of 0.1 mg/kg ICG, the camera registered the NIR fluorescence intensity over time on the dorsum of the feet for 15 min using the Quest Spectrum Platform®. Time-intensity curves were plotted for three regions of interest (ROI): (1) the dorsum of the foot, (2) the forefoot, and (3) the hallux. Time-intensity curves were normalized for maximum fluorescence intensity. Extracted parameters were the maximum slope, area under the curve (AUC) for the ingress, and the AUC for the egress. The non-treated contralateral leg was used as a control group. Results Successful revascularization was performed in 32 patients. There was a significant increase for the maximum slope and AUC egress in all three ROIs. The most significant difference was seen for the maximum slope in ROI 3 (3.7%/s to 6.6%/s, p < 0.001). In the control group, no significant differences were seen for the maximum slope and AUC egress in all ROIs. Conclusions This study shows the potential of ICG NIR fluorescence imaging in assessing the effect of revascularization procedures on foot perfusion. Future studies should focus on the use of this technique in predicting favorable outcome of revascularization procedures.

NIR fluorescence imaging of lipid drops viscosity in liver organs of diabetic mice

2021 ◽  
Vol 187 ◽  
pp. 109120
Author(s):  
Bingli Lu ◽  
Junling Yin ◽  
Cong Liu ◽  
Weiying Lin
Keyword(s):  
Fluorescence Imaging ◽  
Diabetic Mice ◽  
Nir Fluorescence

Gold nanoparticle-enhanced near infrared fluorescent nanocomposites for targeted bio-imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Hao Cheng ◽  
Chuanxi Wang ◽  
Zhenzhu Xu ◽  
Huihui Lin ◽  
Chi Zhang
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Gold Nanoparticle ◽  
Near Infrared ◽  
Water Solubility ◽  
Imaging Agents ◽  
Nir Fluorescence ◽  
Target Imaging ◽  
Bio Imaging ◽  
Low Toxicity

Folic acid-conjugated nanocomposites with NIR fluorescence, water-solubility, and low toxicity are prepared and used as target-imaging agents for cancer cells.

scholarly journals Noncovalent Attachment of PbS Quantum Dots to Single- and Multiwalled Carbon Nanotubes

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Anirban Das ◽  
Eric Hall ◽  
Chien M. Wai
Keyword(s):  
Carbon Nanotubes ◽  
Quantum Dots ◽  
Oleic Acid ◽  
Multiwalled Carbon Nanotubes ◽  
Single Walled Carbon Nanotubes ◽  
Stacking Interactions ◽  
Multiwalled Carbon ◽  
Nir Fluorescence ◽  
Walled Carbon Nanotubes ◽  
Pbs Quantum Dots

Attachment of PbS quantum dots (QD) to single-walled carbon nanotubes (SWNT) and multiwalled carbon nanotubes (MWCNT) is described; wherein commercially obtained PbS-QD of size 2.7 nm, stabilized by oleic acid, are added to a suspension of single- or multiwalled carbon nanotubes (CNT) prefunctionalized noncovalently with 1,2-benzenedimethanethiol (1,2-BDMT) in ethanol. The aromatic part of 1,2-BDMT attaches to the CNT byπ-πstacking interactions, noncovalently functionalizing the CNT. The thiol part of the 1,2-BDMT on the functionalized CNT replaces oleic acid on the surface of the QD facilitating the noncovalent attachment of the QD to the CNT. The composites were characterized by TEM and FTIR spectroscopy. Quenching of NIR fluorescence of the PbS-QD on attachment to the carbon nanotubes (CNT) was observed, indicating FRET from the QD to the CNT.

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