scholarly journals Non-ribosomal Propeptide Precursor in Nocardicin A Biosynthesis Predicted from Adenylation Domain Specificity Dependent on the MbtH Family Protein NocI

2013 ◽  
Vol 135 (5) ◽  
pp. 1749-1759 ◽  
Author(s):  
Jeanne M. Davidsen ◽  
David M. Bartley ◽  
Craig A. Townsend
Keyword(s):  
Domain Specificity ◽  
Adenylation Domain ◽  
Family Protein ◽  
Nocardicin A

scholarly journals Directed Evolution Reveals the Functional Sequence Space of an Adenylation Domain Specificity Code

2019 ◽  
Vol 14 (9) ◽  
pp. 2044-2054 ◽  
Author(s):  
Kurt Throckmorton ◽  
Vladimir Vinnik ◽  
Ratul Chowdhury ◽  
Taylor Cook ◽  
Marc G. Chevrette ◽  
...  
Keyword(s):  
Directed Evolution ◽  
Sequence Space ◽  
Domain Specificity ◽  
Adenylation Domain ◽  
Functional Sequence

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

2012 ◽  
Vol 51 (29) ◽  
pp. 7181-7184 ◽  
Author(s):  
Jenny Thirlway ◽  
Richard Lewis ◽  
Laura Nunns ◽  
Majid Al Nakeeb ◽  
Matthew Styles ◽  
...  
Keyword(s):  
Amino Acid ◽  
Domain Specificity ◽  
Peptide Antibiotic ◽  
Adenylation Domain ◽  
Natural Amino Acid ◽  
Nonribosomal Peptide

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

2012 ◽  
Vol 124 (29) ◽  
pp. 7293-7296 ◽  
Author(s):  
Jenny Thirlway ◽  
Richard Lewis ◽  
Laura Nunns ◽  
Majid Al Nakeeb ◽  
Matthew Styles ◽  
...  
Keyword(s):  
Amino Acid ◽  
Domain Specificity ◽  
Peptide Antibiotic ◽  
Adenylation Domain ◽  
Natural Amino Acid ◽  
Nonribosomal Peptide

scholarly journals Directed Evolution of an Adenylation Domain Specificity Code

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Vladimir Vinnik ◽  
Kurt Throckmorton ◽  
Taylor B. Cook ◽  
Brian F. Pfleger ◽  
Michael G. Thomas
Keyword(s):  
Directed Evolution ◽  
Domain Specificity ◽  
Adenylation Domain

scholarly journals NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

2011 ◽  
Vol 39 (suppl_2) ◽  
pp. W362-W367 ◽  
Author(s):  
Marc Röttig ◽  
Marnix H. Medema ◽  
Kai Blin ◽  
Tilmann Weber ◽  
Christian Rausch ◽  
...  
Keyword(s):  
Web Server ◽  
Domain Specificity ◽  
Adenylation Domain

Testing the Limits of Domain Specificity

1996 ◽  
Vol 41 (8) ◽  
pp. 828-829
Author(s):  
Amanda L. Woodward
Keyword(s):  
Domain Specificity

Domain specificity in inhibition of responding by macaques

2006 ◽  
Author(s):  
David A. Washburn ◽  
Michael J. Beran ◽  
Theodore A. Evans ◽  
Eric J. Vanman
Keyword(s):  
Domain Specificity

Hierarchical goals and social adjustment: Domain specificity of the meditational processes involving regulatory competence

2011 ◽  
Author(s):  
Hiroyuki Yoshizawa ◽  
Makoto Nakajima ◽  
Takuya Yoshida ◽  
Chika Harada ◽  
Koji Tsuchiya
Keyword(s):  
Social Adjustment ◽  
Domain Specificity ◽  
Hierarchical Goals

Factor VIII Inhibitor Antibodies with C2 Domain Specificity Are Less inhibitory to Factor VIII Complexed with von Willebrand Factor

1996 ◽  
Vol 76 (05) ◽  
pp. 749-754 ◽  
Author(s):  
Suzuki Suzuki ◽  
Morio Arai ◽  
Kagehiro Amano ◽  
Kazuhiko Kagawa ◽  
Katsuyuki Fukutake
Keyword(s):  
Complex Formation ◽  
Factor Viii ◽  
Von Willebrand Factor ◽  
Domain Specificity ◽  
Factor Viii Inhibitor ◽  
C2 Domain ◽  
Recombinant Fviii ◽  
Von Willebrand ◽  
A2 Domain ◽  
Willebrand Factor

SummaryIn order to clarify the potential role of von Willebrand factor (vWf) in attenuating the inactivation of factor VIII (fVIII) by those antibodies with C2 domain specificity, we investigated a panel of 14 human antibodies to fVIII. Immunoblotting analysis localized light chain (C2 domain) epitopes for four cases, heavy chain (A2 domain) epitopes in five cases, while the remaining five cases were both light and heavy chains. The inhibitor titer was considerably higher for Kogenate, a recombinant fVIII concentrate, than for Haemate P, a fVIII/vWf complex concentrate, in all inhibitor plasmas that had C2 domain specificity. In five inhibitor plasmas with A2 domain specificity and in five with both A2 and C2 domain specificities, Kogenate gave titers similar to or lower than those with Haemate P. The inhibitory effect of IgG of each inhibitor plasma was then compared with recombinant fVIII and its complex with vWf. When compared to the other 10 inhibitor IgGs, IgG concentration, which inhibited 50% of fVIII activity (IC50), was remarkably higher for the fVIII/vWf complex than for fVIII in all the inhibitor IgGs that had C2 domain reactivity. Competition of inhibitor IgG and vWf for fVIII binding was observed in an ELISA system. In 10 inhibitors that had C2 domain reactivity, the dose dependent inhibition of fVIII-vWf complex formation was observed, while, in the group of inhibitors with A2 domain specificity, there was no inhibition of the complex formation except one case. We conclude that a subset of fVIII inhibitors, those that bind to C2 domain determinants, are less inhibitory to fVIII when it is complexed with vWf that binds to overlapping region in the C2 domain.

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