scholarly journals The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

2012 ◽  
Vol 134 (33) ◽  
pp. 13535-13537 ◽  
Author(s):  
Catherine Leimkuhler Grimes ◽  
Lushanti De Zoysa Ariyananda ◽  
James E. Melnyk ◽  
Erin K. O’Shea
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Innate Immune ◽  
Cell Wall Fragment

Bacterial cell wall macroamphiphiles: Pathogen-/microbe-associated molecular patterns detected by mammalian innate immune system

Biochimie ◽  
2013 ◽  
Vol 95 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Aurélie Ray ◽  
Marlène Cot ◽  
Germain Puzo ◽  
Martine Gilleron ◽  
Jérôme Nigou
Keyword(s):  
Cell Wall ◽  
Immune System ◽  
Bacterial Cell ◽  
Innate Immune System ◽  
Bacterial Cell Wall ◽  
Innate Immune ◽  
Molecular Patterns

CD14, An Innate Immune Receptor for Various Bacterial Cell Wall Components

2020 ◽  
pp. 463-471
Author(s):  
Artur J. Ulmer ◽  
Volker T. El-Samalouti ◽  
Ernst T. Rietschel ◽  
Hans-Dieter Flad ◽  
Roman Dziarski
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Innate Immune ◽  
Immune Receptor ◽  
Cell Wall Components ◽  
Innate Immune Receptor ◽  
Wall Components

scholarly journals The role of bacterial cell wall dimers in the innate immune response (970.1)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Lauren Genova ◽  
James Melnyk ◽  
Vishnu Mohanan ◽  
Catherine Grimes
Keyword(s):  
Immune Response ◽  
Cell Wall ◽  
Innate Immune Response ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Innate Immune

Peptidoglycan Deacetylases in Bacterial Cell Wall Remodeling and Pathogenesis

2021 ◽  
Vol 28 ◽  
Author(s):  
Antoni Planas
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Biochemical Characterization ◽  
Dynamic Structure ◽  
Bacterial Cell Wall ◽  
Innate Immune ◽  
Functional Roles ◽  
Bacterial Division

: The bacterial cell wall peptidoglycan (PG) is a dynamic structure that is constantly synthesized, re-modeled and degraded during bacterial division and growth. Post-synthetic modifications modulate the action of endogenous autolysis during PG lysis and remodeling for growth and sporulation, but also they are a mechanism used by pathogenic bacteria to evade the host innate immune system. Modifica-tions of the glycan backbone are limited to the C-2 amine and the C-6 hydroxyl moieties of either Glc-NAc or MurNAc residues. This paper reviews the functional roles and properties of peptidoglycan de-N-acetylases (distinct PG GlcNAc and MurNAc deacetylases) and recent progress through genetic stud-ies and biochemical characterization to elucidate their mechanism of action, 3D structures, substrate specificities and biological functions. Since they are virulence factors in pathogenic bacteria, peptidogly-can deacetylases are potential targets for the design of novel antimicrobial agents.

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