Real-Time NMR Characterization of Structure and Dynamics in a Transiently Populated Protein Folding Intermediate

2012 ◽  
Vol 134 (19) ◽  
pp. 8066-8069 ◽  
Author(s):  
Enrico Rennella ◽  
Thomas Cutuil ◽  
Paul Schanda ◽  
Isabel Ayala ◽  
Vincent Forge ◽  
...  
Keyword(s):  
Protein Folding ◽  
Real Time ◽  
Folding Intermediate ◽  
Structure And Dynamics ◽  
Nmr Characterization

Fluorescence, CD, attenuated total reflectance (ATR) FTIR, and carbon-13 NMR characterization of the structure and dynamics of synthetic melittin and melittin analogs in lipid environments

Biochemistry ◽  
1992 ◽  
Vol 31 (5) ◽  
pp. 1301-1313 ◽  
Author(s):  
Arthur J. Weaver ◽  
Marvin D. Kemple ◽  
Joseph W. Brauner ◽  
Richard Mendelsohn ◽  
Franklyn G. Prendergast
Keyword(s):  
Attenuated Total Reflectance ◽  
Total Reflectance ◽  
Structure And Dynamics ◽  
Nmr Characterization

NMR Characterization of the Structure and Dynamics of a Cavitand–SDS Complex

2007 ◽  
Vol 19 (6) ◽  
pp. 399-402 ◽  
Author(s):  
Wayne E. Steinmetz ◽  
William R. Trevor
Keyword(s):  
Structure And Dynamics ◽  
Nmr Characterization

scholarly journals NMR characterization of substrate induced changes in structure and dynamics of human phosphomevalonate kinase

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Andrew L Olson ◽  
Huili Yao ◽  
Shen Cai ◽  
Tim Herdendorf ◽  
Henry M Miziorko ◽  
...  
Keyword(s):  
Structure And Dynamics ◽  
Nmr Characterization ◽  
Phosphomevalonate Kinase ◽  
Induced Changes

scholarly journals ATP emerged to induce protein folding, inhibit aggregation and increase stability

2019 ◽  
Author(s):  
Jian Kang ◽  
Liangzhong Lim ◽  
Jianxing Song
Keyword(s):  
Protein Folding ◽  
Small Molecules ◽  
Origin Of Life ◽  
Protein Homeostasis ◽  
Nmr Characterization ◽  
General Capacity ◽  
The Origin Of Life ◽  
First Time ◽  
Control Protein

AbstractBy NMR characterization of effects of ATP and related molecules on the folding and dynamics of the ALS-causing C71G-PFN1 and nascent hSOD1, we reveal for the first time that ATP has a general capacity in inducing protein folding with the highest efficiency known so far. This capacity was further identified to result from triphosphate, a key intermediate in prebiotic chemistry, which, however, can severely trigger protein aggregation. Remarkably, by joining adenosine and triphosphate together, ATP integrates three abilities to simultaneously induce protein folding, inhibit aggregation and increase thermodynamic stability. Our study implies that the emergence of ATP might represent an irreplaceable step essential for the Origin of Life, and decrypts a principle for engineering small molecules with three functions to treat aggregation-associated ageing and diseases.One sentence summaryBy joining adenosine and triphosphate, ATP integrates three abilities to control protein homeostasis for the Origin of Life.

Chapter 14 Real Time Investigation of Protein Folding, Structure, and Dynamics in Living Cells

2008 ◽  
pp. 287-325 ◽  
Author(s):  
Qianqian Li ◽  
Yuefei Huang ◽  
Nan Xiao ◽  
Victoria Murray ◽  
Jianglei Chen ◽  
...  
Keyword(s):  
Protein Folding ◽  
Real Time ◽  
Living Cells ◽  
Structure And Dynamics ◽  
Folding Structure
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