NMR Study on the B–Z Junction Formation of DNA Duplexes Induced by Z-DNA Binding Domain of Human ADAR1

2012 ◽  
Vol 134 (11) ◽  
pp. 5276-5283 ◽  
Author(s):  
Yeon-Mi Lee ◽  
Hee-Eun Kim ◽  
Chin-Ju Park ◽  
Ae-Ree Lee ◽  
Hee-Chul Ahn ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Dna Duplexes ◽  
Nmr Study ◽  
Junction Formation ◽  
Z Dna

NMR dynamics study of the Z-DNA binding domain of human ADAR1 bound to various DNA duplexes

2012 ◽  
Vol 428 (1) ◽  
pp. 137-141 ◽  
Author(s):  
Ae-Ree Lee ◽  
Hee-Eun Kim ◽  
Yeon-Mi Lee ◽  
Minjee Jeong ◽  
Kwang-Ho Choi ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Dna Duplexes ◽  
Z Dna

Novel Interaction of the Z-DNA Binding Domain of Human ADAR1 with the Oncogenic c-Myc Promoter G-Quadruplex

2014 ◽  
Vol 426 (14) ◽  
pp. 2594-2604 ◽  
Author(s):  
Hyun-Jin Kang ◽  
Tuong Vy Thi Le ◽  
Kyungmin Kim ◽  
Jeonghwan Hur ◽  
Kyeong Kyu Kim ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
G Quadruplex ◽  
Z Dna

scholarly journals Distinct Z-DNA binding mode of a PKR-like protein kinase containing a Z-DNA binding domain (PKZ)

2014 ◽  
Vol 42 (9) ◽  
pp. 5937-5948 ◽  
Author(s):  
Doyoun Kim ◽  
Jeonghwan Hur ◽  
Kwangsoo Park ◽  
Sangsu Bae ◽  
Donghyuk Shin ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Dna Binding ◽  
Binding Mode ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Z Dna

scholarly journals Structural and functional studies of a large winged Z-DNA-binding domain ofDanio rerioprotein kinase PKZ

FEBS Letters ◽  
2016 ◽  
Vol 590 (14) ◽  
pp. 2275-2285 ◽  
Author(s):  
Vinod Kumar Subramani ◽  
Doyoun Kim ◽  
Kyunghee Yun ◽  
Kyeong Kyu Kim
Keyword(s):  
Dna Binding ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Functional Studies ◽  
Z Dna

Spectroscopic Characterization of a DNA-Binding Domain, Zα, from the Editing Enzyme, dsRNA Adenosine Deaminase:  Evidence for Left-Handed Z-DNA in the Zα−DNA Complex†

Biochemistry ◽  
1998 ◽  
Vol 37 (38) ◽  
pp. 13313-13321 ◽  
Author(s):  
Imre Berger ◽  
William Winston ◽  
Ramasamy Manoharan ◽  
Thomas Schwartz ◽  
Jens Alfken ◽  
...  
Keyword(s):  
Dna Binding ◽  
Adenosine Deaminase ◽  
Spectroscopic Characterization ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Left Handed ◽  
Z Dna ◽  
Editing Enzyme ◽  
Dna Complex

scholarly journals Solution structure of the free Zα domain of human DLM-1 (ZBP1/DAI), a Z-DNA binding domain

2014 ◽  
Vol 60 (2-3) ◽  
pp. 189-195 ◽  
Author(s):  
Yunhuang Yang ◽  
Theresa A. Ramelot ◽  
Hsiau-Wei Lee ◽  
Rong Xiao ◽  
John K. Everett ◽  
...  
Keyword(s):  
Dna Binding ◽  
Solution Structure ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Z Dna

scholarly journals BZLF1 Activation of the Methylated Form of the BRLF1 Immediate-Early Promoter Is Regulated by BZLF1 Residue 186

2005 ◽  
Vol 79 (12) ◽  
pp. 7338-7348 ◽  
Author(s):  
Prasanna M. Bhende ◽  
William T. Seaman ◽  
Henri-Jacques Delecluse ◽  
Shannon C. Kenney
Keyword(s):  
Dna Binding ◽  
Gene Transcription ◽  
Viral Genome ◽  
Gene Promoter ◽  
Binding Domain ◽  
Immediate Early ◽  
Dna Binding Domain ◽  
Barr Virus ◽  
Z Dna ◽  
Epstein Barr

ABSTRACT The Epstein-Barr virus (EBV) genome is highly methylated in latently infected cells. We recently reported that the EBV immediate-early (IE) protein BZLF1 (Z) preferentially binds to and activates transcription from the methylated form of the BRLF1 IE gene promoter (Rp). We now report that serine residue 186 in the Z DNA-binding domain plays an important role in the ability of Z to bind to and activate methylated Rp. A Z mutant containing an alanine residue at position 186 [Z(S186A)] was significantly defective in binding to methylated, as well as unmethylated, ZREs (Z-responsive elements) in Rp and was unable to activate lytic EBV gene transcription from the methylated or demethylated form of the viral genome. A Z mutant containing threonine at residue 186 [Z(S186T)] bound only to the methylated form of the ZRE-2 site in Rp and induced lytic EBV gene transcription from the methylated, but not demethylated, form of the viral genome. The defect in both of these mutants was primarily due to an inability to activate the Rp in the context of the viral genome. Finally, a Z mutant containing an aspartic acid at position 186 [Z(S186D)] did not bind to either the consensus AP-1 site or to the methylated or unmethylated Rp ZRE-2 site and did not induce lytic gene transcription. These results indicate that replacement of serine with threonine at residue 186 in the Z DNA-binding domain differentially affects its ability to reactivate the unmethylated, versus methylated, viral genome.

scholarly journals A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase

1997 ◽  
Vol 94 (16) ◽  
pp. 8421-8426 ◽  
Author(s):  
A. Herbert ◽  
J. Alfken ◽  
Y.-G. Kim ◽  
I. S. Mian ◽  
K. Nishikura ◽  
...  
Keyword(s):  
Dna Binding ◽  
Adenosine Deaminase ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Double Stranded Rna ◽  
Z Dna ◽  
Editing Enzyme
Sign in / Sign up

Export Citation Format

Share Document