scholarly journals Design of a Bioactive Small Molecule That Targets the Myotonic Dystrophy Type 1 RNA via an RNA Motif–Ligand Database and Chemical Similarity Searching

2012 ◽  
Vol 134 (10) ◽  
pp. 4731-4742 ◽  
Author(s):  
Raman Parkesh ◽  
Jessica L. Childs-Disney ◽  
Masayuki Nakamori ◽  
Amit Kumar ◽  
Eric Wang ◽  
...  
Keyword(s):  
Myotonic Dystrophy ◽  
Small Molecule ◽  
Similarity Searching ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type ◽  
Chemical Similarity ◽  
Rna Motif

scholarly journals Mitigating RNA Toxicity in Myotonic Dystrophy using Small Molecules

2019 ◽  
Vol 20 (16) ◽  
pp. 4017 ◽  
Author(s):  
Kaalak Reddy ◽  
Jana R. Jenquin ◽  
John D. Cleary ◽  
J. Andrew Berglund
Keyword(s):  
Small Molecules ◽  
Myotonic Dystrophy ◽  
Small Molecule ◽  
Disease Onset ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type ◽  
Rna Toxicity ◽  
Complex Mechanisms ◽  
Potential Use

This review, one in a series on myotonic dystrophy (DM), is focused on the development and potential use of small molecules as therapeutics for DM. The complex mechanisms and pathogenesis of DM are covered in the associated reviews. Here, we examine the various small molecule approaches taken to target the DNA, RNA, and proteins that contribute to disease onset and progression in myotonic dystrophy type 1 (DM1) and 2 (DM2).

scholarly journals Small molecule kinase inhibitors alleviate different molecular features of myotonic dystrophy type 1

RNA Biology ◽  
2014 ◽  
Vol 11 (6) ◽  
pp. 742-754 ◽  
Author(s):  
Marzena Wojciechowska ◽  
Katarzyna Taylor ◽  
Krzysztof Sobczak ◽  
Marek Napierala ◽  
Wlodzimierz J Krzyzosiak
Keyword(s):  
Myotonic Dystrophy ◽  
Small Molecule ◽  
Kinase Inhibitors ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type ◽  
Molecular Features

SEVERE CONGENITAL MYOTONIC DYSTROPHY TYPE 1

2018 ◽  
Vol 97 (1) ◽  
pp. 78-81
Author(s):  
E.A. Mamaeva ◽  
◽  
L.A. Fedorova ◽  
S.E. Voronovich ◽  
V.D. Nazarov ◽  
...  
Keyword(s):  
Myotonic Dystrophy ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type ◽  
Congenital Myotonic Dystrophy
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