scholarly journals Intercepting Bacterial Indole Signaling with Flustramine Derivatives

2011 ◽  
Vol 133 (50) ◽  
pp. 20160-20163 ◽  
Author(s):  
Cynthia A. Bunders ◽  
Marine J. Minvielle ◽  
Roberta J. Worthington ◽  
Minoshka Ortiz ◽  
John Cavanagh ◽  
...  
Keyword(s):  
Indole Signaling

scholarly journals Indole Acts as an Extracellular Cue Regulating Gene Expression in Vibrio cholerae

2009 ◽  
Vol 191 (11) ◽  
pp. 3504-3516 ◽  
Author(s):  
Ryan S. Mueller ◽  
Sinem Beyhan ◽  
Simran G. Saini ◽  
Fitnat H. Yildiz ◽  
Douglas H. Bartlett
Keyword(s):  
Gene Expression ◽  
Vibrio Cholerae ◽  
Biofilm Formation ◽  
Signal Molecule ◽  
Control Of Gene Expression ◽  
Protozoan Grazing ◽  
Extracellular Signal ◽  
Grazing Resistance ◽  
Indole Signaling

ABSTRACT Indole has been proposed to act as an extracellular signal molecule influencing biofilm formation in a range of bacteria. For this study, the role of indole in Vibrio cholerae biofilm formation was examined. It was shown that indole activates genes involved in vibrio polysaccharide (VPS) production, which is essential for V. cholerae biofilm formation. In addition to activating these genes, it was determined using microarrays that indole influences the expression of many other genes, including those involved in motility, protozoan grazing resistance, iron utilization, and ion transport. A transposon mutagenesis screen revealed additional components of the indole-VPS regulatory circuitry. The indole signaling cascade includes the DksA protein along with known regulators of VPS production, VpsR and CdgA. A working model is presented in which global control of gene expression by indole is coordinated through σ54 and associated transcriptional regulators.

scholarly journals Cellular Stress Upregulates Indole Signaling Metabolites in Escherichia coli

2020 ◽  
Vol 27 (6) ◽  
pp. 698-707.e7
Author(s):  
Chung Sub Kim ◽  
Jhe-Hao Li ◽  
Brenden Barco ◽  
Hyun Bong Park ◽  
Alexandra Gatsios ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Cellular Stress ◽  
Indole Signaling

scholarly journals RpoS and Indole Signaling Control the Virulence of Vibrio anguillarum towards Gnotobiotic Sea Bass (Dicentrarchus labrax) Larvae

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e111801 ◽  
Author(s):  
Xuan Li ◽  
Qian Yang ◽  
Kristof Dierckens ◽  
Debra L. Milton ◽  
Tom Defoirdt
Keyword(s):  
Vibrio Anguillarum ◽  
Dicentrarchus Labrax ◽  
Sea Bass ◽  
Indole Signaling ◽  
Dicentrarchus Labrax Larvae

scholarly journals Erratum for Kumar et al., “Indole Signaling at the Host-Microbiota-Pathogen Interface”

mBio ◽  
2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Aman Kumar ◽  
Vanessa Sperandio
Keyword(s):  
Indole Signaling

scholarly journals Interspecies and Intraspecies Signals Synergistically Regulate Lysobacter enzymogenes Twitching Motility

2019 ◽  
Vol 85 (23) ◽  
Author(s):  
Tao Feng ◽  
Yong Han ◽  
Bingqing Li ◽  
Zhiqiang Li ◽  
Yameng Yu ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Gene Cluster ◽  
Gene Clusters ◽  
Research Area ◽  
Twitching Motility ◽  
Content Type ◽  
Dependent Behavior ◽  
Novel Theory ◽  
Important Research Area ◽  
Indole Signaling

ABSTRACT The twitching motility of bacteria is closely related to environmental adaptability and pathogenic behaviors. Lysobacter is a good genus in which to study twitching motility because of the complex social activities and distinct movement patterns of its members. Regardless, the mechanism that induces twitching motility is largely unknown. In this study, we found that the interspecies signal indole caused Lysobacter to have irregular, random twitching motility with significantly enhanced speed. Deletion of qseC or qseB from the two-component system for indole signaling perception resulted in the disappearance of rapid, random movements and significantly decreased twitching activity. Indole-induced, rapid, random twitching was achieved through upregulation of expression of gene cluster pilE1-pilY11-pilX1-pilW1-pilV1-fimT1. In addition, under conditions of extremely low bacterial density, individual Lysobacter cells grew and divided in a stable manner in situ without any movement. The intraspecies quorum-sensing signaling factor 13-methyltetradecanoic acid, designated L. enzymogenes diffusible signaling factor (LeDSF), was essential for Lysobacter to produce twitching motility through indirect regulation of gene clusters pilM-pilN-pilO-pilP-pilQ and pilS1-pilR-pilA-pilB-pilC. These results demonstrate that the motility of Lysobacter is induced and regulated by indole and LeDSF, which reveals a novel theory for future studies of the mechanisms of bacterial twitching activities. IMPORTANCE The mechanism underlying bacterial twitching motility is an important research area because it is closely related to social and pathogenic behaviors. The mechanism mediating cell-to-cell perception of twitching motility is largely unknown. Using Lysobacter as a model, we found in this study that the interspecies signal indole caused Lysobacter to exhibit irregular, random twitching motility via activation of gene cluster pilE1-pilY11-pilX1-pilW1-pilV1-fimT1. In addition, population-dependent behavior induced by 13-methyltetradecanoic acid, a quorum-sensing signaling molecule designated LeDSF, was involved in twitching motility by indirectly regulating gene clusters pilM-pilN-pilO-pilP-pilQ and pilS1-pilR-pilA-pilB-pilC. The results demonstrate that the twitching motility of Lysobacter is regulated by these two signaling molecules, offering novel clues for exploring the mechanisms of twitching motility and population-dependent behaviors of bacteria.

scholarly journals In vitro activity of AST-120 that suppresses indole signaling in Escherichia coli, which attenuates drug tolerance and virulence

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0232461
Author(s):  
Hidetada Hirakawa ◽  
Motoyuki Uchida ◽  
Kumiko Kurabayashi ◽  
Fuyuhiko Nishijima ◽  
Ayako Takita ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Drug Tolerance ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Indole Signaling

Indole signaling decreases biofilm formation and related virulence of Listeria monocytogenes

2020 ◽  
Vol 367 (14) ◽  
Author(s):  
Paramaporn Rattanaphan ◽  
Pimonsri Mittraparp-Arthorn ◽  
Kanitta Srinoun ◽  
Varaporn Vuddhakul ◽  
Natta Tansila
Keyword(s):  
Listeria Monocytogenes ◽  
Quorum Sensing ◽  
Biofilm Formation ◽  
Cell Aggregation ◽  
Signal Molecules ◽  
Bacterial Survival ◽  
Gene Encoding ◽  
Cellular Processes ◽  
Molecular Approaches ◽  
Indole Signaling

ABSTRACT Bacterial communication system known as quorum sensing (QS) is a pivotal system for bacterial survival, adaptation and pathogenesis. Members in the multicellular community may synthesize or acquire a signaling molecule in order to elicit downstream cellular processes. Roles of indole and derivatives, a new class of quorum-sensing signal molecules, in various bacterial physiologies and virulence have been reported recently. Indole is normally found in mammal gastrointestinal tract as a metabolite of tryptophan metabolism by microbiota. Therefore, interspecies connection via indole signaling among commensal bacteria and enteric pathogens could be anticipated. Effects of indole exposure on the virulence of Listeria monocytogenes were investigated by phenotypic and molecular approaches. Results demonstrated that synthetic indole and indole-rich conditioned medium significantly diminished biofilm formation and related virulence of L. monocytogenes including motility, cell aggregation and exopolysaccharide production. Transcript levels of virulence-associated (pssE, dltA, flaA, fliI, motB, agrA and hly) and regulatory genes (codY, sigB, prfA and gmaR) were substantially downregulated in indole-treated cells. Only mogR gene encoding for a repressor of motility genes was upregulated after indole exposure. Our findings raise the possibility that L. monocytogenes may acquire indole signaling from gut microbiota for resource-effective adaptation upon transition to new environment.

Dynamics of transcription–translation coordination tune bacterial indole signaling

2019 ◽  
Vol 16 (4) ◽  
pp. 440-449 ◽  
Author(s):  
Tianmin Wang ◽  
Xiang Zheng ◽  
Haonan Ji ◽  
Ting-Liang Wang ◽  
Xin-Hui Xing ◽  
...  
Keyword(s):  
Indole Signaling
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