A Unique Class of Near-Infrared Functional Fluorescent Dyes with Carboxylic-Acid-Modulated Fluorescence ON/OFF Switching: Rational Design, Synthesis, Optical Properties, Theoretical Calculations, and Applications for Fluorescence Imaging in Living Animals

2012 ◽  
Vol 134 (2) ◽  
pp. 1200-1211 ◽  
Author(s):  
Lin Yuan ◽  
Weiying Lin ◽  
Yueting Yang ◽  
Hua Chen
Keyword(s):  
Optical Properties ◽  
Carboxylic Acid ◽  
Fluorescence Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Fluorescent Dyes ◽  
Theoretical Calculations ◽  
Design Synthesis ◽  
Modulated Fluorescence

Theoretical Framework of 1,3-Thiazolium-5-Thiolates Mesoionic Compounds: Exploring the Nature of Photophysical Properties and Molecular Nonlinearity

2020 ◽  
Author(s):  
Zeyu Liu ◽  
Shugui Hua ◽  
Tian Lu ◽  
Ziqi Tian
Keyword(s):  
Optical Properties ◽  
Rational Design ◽  
Rayleigh Scattering ◽  
Function Analysis ◽  
Theoretical Calculations ◽  
Photophysical Properties ◽  
Optical Nonlinearity ◽  
Nonlinear Properties ◽  
Photoelectric Performance ◽  
Wave Function Analysis

Inspired by a previous experimental study on the first-order hyperpolarizabilities of 1,3-thiazolium-5-thiolates mesoionic compounds using Hyper-Rayleigh scattering technique, we theoretically investigated the UV-Vis absorption spectra and every order polarizabilities of these mesoionic molecules. Based on the fact that the photophysical and nonlinear properties observed in the experiment can be perfectly replicated, our theoretical calculations explored the essential characteristics of the optical properties of the mesoionic compounds with different electron-donating groups at the level of electronic structures through various wave function analysis methods. The influence of the electron-donating ability of the donor on the optical properties of the molecules and the contribution of the mesoionic ring moiety to their optical nonlinearity are clarified, which have not been reported by any research so far. This work will help people understand the nature of optical properties of mesoionic-based molecules and provide guidance for the rational design of molecules with excellent photoelectric performance in the future.

scholarly journals Towards rational design and optimization of near-field enhancement and spectral tunability of hybrid core-shell plasmonic nanoprobes

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Debadrita Paria ◽  
Chi Zhang ◽  
Ishan Barman
Keyword(s):  
Single Molecule ◽  
Rational Design ◽  
Near Infrared ◽  
Theoretical Calculations ◽  
Near Field ◽  
Field Enhancement ◽  
Infrared Region ◽  
Core Shell ◽  
Optimization Strategy ◽  
Design And Optimization

Abstract In biology, sensing is a major driver of discovery. A principal challenge is to create a palette of probes that offer near single-molecule sensitivity and simultaneously enable multiplexed sensing and imaging in the “tissue-transparent” near-infrared region. Surface-enhanced Raman scattering and metal-enhanced fluorescence have shown substantial promise in addressing this need. Here, we theorize a rational design and optimization strategy to generate nanostructured probes that combine distinct plasmonic materials sandwiching a dielectric layer in a multilayer core shell configuration. The lower energy resonance peak in this multi-resonant construct is found to be highly tunable from visible to the near-IR region. Such a configuration also allows substantially higher near-field enhancement, compared to a classical core-shell nanoparticle that possesses a single metallic shell, by exploiting the differential coupling between the two core-shell interfaces. Combining such structures in a dimer configuration, which remains largely unexplored at this time, offers significant opportunities not only for near-field enhancement but also for multiplexed sensing via the (otherwise unavailable) higher order resonance modes. Together, these theoretical calculations open the door for employing such hybrid multi-layered structures, which combine facile spectral tunability with ultrahigh sensitivity, for biomolecular sensing.

Synthesis and optical properties of emission-tunable PbS/CdS core–shell quantum dots for in vivo fluorescence imaging in the second near-infrared window

RSC Advances ◽  
2014 ◽  
Vol 4 (77) ◽  
pp. 41164-41171 ◽  
Author(s):  
Yoshikazu Tsukasaki ◽  
Masatoshi Morimatsu ◽  
Goro Nishimura ◽  
Takao Sakata ◽  
Hidehiro Yasuda ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Core Shell ◽  
Cds Quantum Dots ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Infrared Window

This paper describes the synthesis and optical properties of PbS/CdS quantum dots for in vivo fluorescence imaging.

scholarly journals Rational design of a NIR-II fluorescent nano-system with maximized fluorescence performance and applications

2021 ◽  
Author(s):  
Haoli Yu ◽  
Yuesong Wang ◽  
Yan Chen ◽  
Min Ji
Keyword(s):  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Nir Fluorescence

Purpose: Near-infrared (NIR) fluorescence imaging (FI) become a research hotspot in the field of in vivo imaging. Here, we intend to synthesize a NIR-II fluorescence nano-system with an excellent fluorescence...

Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

2020 ◽  
Author(s):  
wei zhu ◽  
Miaomiao Kang ◽  
qian wu ◽  
Zhijun Zhang ◽  
yi wu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Molecular Design ◽  
Infrared Region ◽  
High Fidelity ◽  
Facile Synthesis ◽  
Rational Molecular Design ◽  
Near Infrared Region ◽  
Synthesis Protocol

Fluorescence imaging in the second near-infrared region (NIR-II) can penetrate tissue at centimeter depths and obtain high fidelity of images. However, facile synthesis of small-molecule fluorescent photosensitizers for efficient NIR-II fluorescence imaging as well as photodynamic and photothermal combinatorial therapies (PDT-PTT) is still a challenging task. Herein, we reported a rational design and facile synthesis protocol for a series of novel NIR-emissive zwitterionic luminogens with aggregation-induced emission (AIE) features for cancer phototheranostics.

scholarly journals Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

2020 ◽  
Author(s):  
wei zhu ◽  
Miaomiao Kang ◽  
qian wu ◽  
Zhijun Zhang ◽  
yi wu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Molecular Design ◽  
Infrared Region ◽  
High Fidelity ◽  
Facile Synthesis ◽  
Rational Molecular Design ◽  
Near Infrared Region ◽  
Synthesis Protocol

Fluorescence imaging in the second near-infrared region (NIR-II) can penetrate tissue at centimeter depths and obtain high fidelity of images. However, facile synthesis of small-molecule fluorescent photosensitizers for efficient NIR-II fluorescence imaging as well as photodynamic and photothermal combinatorial therapies (PDT-PTT) is still a challenging task. Herein, we reported a rational design and facile synthesis protocol for a series of novel NIR-emissive zwitterionic luminogens with aggregation-induced emission (AIE) features for cancer phototheranostics.

Theoretical Framework of 1,3-Thiazolium-5-Thiolates Mesoionic Compounds: Exploring the Nature of Photophysical Properties and Molecular Nonlinearity

2020 ◽  
Author(s):  
Zeyu Liu ◽  
Shugui Hua ◽  
Tian Lu ◽  
Ziqi Tian
Keyword(s):  
Optical Properties ◽  
Rational Design ◽  
Rayleigh Scattering ◽  
Function Analysis ◽  
Theoretical Calculations ◽  
Photophysical Properties ◽  
Optical Nonlinearity ◽  
Nonlinear Properties ◽  
Photoelectric Performance ◽  
Wave Function Analysis

Inspired by a previous experimental study on the first-order hyperpolarizabilities of 1,3-thiazolium-5-thiolates mesoionic compounds using Hyper-Rayleigh scattering technique, we theoretically investigated the UV-Vis absorption spectra and every order polarizabilities of these mesoionic molecules. Based on the fact that the photophysical and nonlinear properties observed in the experiment can be perfectly replicated, our theoretical calculations explored the essential characteristics of the optical properties of the mesoionic compounds with different electron-donating groups at the level of electronic structures through various wave function analysis methods. The influence of the electron-donating ability of the donor on the optical properties of the molecules and the contribution of the mesoionic ring moiety to their optical nonlinearity are clarified, which have not been reported by any research so far. This work will help people understand the nature of optical properties of mesoionic-based molecules and provide guidance for the rational design of molecules with excellent photoelectric performance in the future.

A series of novel NIR fluorescent dyes: Synthesis, theoretical calculations and fluorescence imaging applications in living cells

2016 ◽  
Vol 125 ◽  
pp. 220-228 ◽  
Author(s):  
Ming Zhang ◽  
Shu-ting Zheng ◽  
Xiao-jing Liu ◽  
Ying Long ◽  
Bing-qin Yang
Keyword(s):  
Fluorescence Imaging ◽  
Fluorescent Dyes ◽  
Theoretical Calculations ◽  
Living Cells
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