scholarly journals Plasmonic Imaging of Human Oral Cancer Cell Communities during Programmed Cell Death by Nuclear-Targeting Silver Nanoparticles

2011 ◽  
Vol 133 (44) ◽  
pp. 17594-17597 ◽  
Author(s):  
Lauren A. Austin ◽  
Bin Kang ◽  
Chun-Wan Yen ◽  
Mostafa A. El-Sayed
2007 ◽  
Vol 2 (1) ◽  
pp. 196
Author(s):  
R.B. Zain ◽  
S. Hamid ◽  
C.P. Gan ◽  
S.M. Ismail ◽  
W.M.W. Mahadzir ◽  
...  

2015 ◽  
Vol 6 (8) ◽  
pp. 877-881 ◽  
Author(s):  
Patricia G. Cruz ◽  
Andrew M. Fribley ◽  
Justin R. Miller ◽  
Martha J. Larsen ◽  
Pamela J. Schultz ◽  
...  

2021 ◽  
Vol 22 (16) ◽  
pp. 8686
Author(s):  
Rajdeep Chakraborty ◽  
Karen Vickery ◽  
Charbel Darido ◽  
Shoba Ranganathan ◽  
Honghua Hu

Oral cancer is a major global health problem with high incidence and low survival rates. The oral cavity contains biofilms as dental plaques that harbour both Gram-negative and Gram-positive bacterial antigens, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), respectively. LPS and LTA are known to stimulate cancer cell growth, and the bioactive phytochemical capsaicin has been reported to reverse this effect. Here, we tested the efficacy of oral cancer chemotherapy treatment with capsaicin in the presence of LPS, LTA or the combination of both antigens. LPS and LTA were administered to Cal 27 oral cancer cells prior to and/or concurrently with capsaicin, and the treatment efficacy was evaluated by measuring cell proliferation and apoptotic cell death. We found that while capsaicin inhibits oral cancer cell proliferation and metabolism (MT Glo assay) and increases cell death (Trypan blue exclusion assay and Caspase 3/7 expression), its anti-cancer effect was significantly reduced on cells that are either primed or exposed to the bacterial antigens. Capsaicin treatment significantly increased oral cancer cells’ suppressor of cytokine signalling 3 gene expression. This increase was reversed in the presence of bacterial antigens during treatment. Our data establish a rationale for clinical consideration of bacterial antigens that may interfere with the treatment efficacy of oral cancer.


2010 ◽  
Vol 48 (12) ◽  
pp. 1354-1360 ◽  
Author(s):  
WonBong Lim ◽  
OkSu Kim ◽  
JinAn Jung ◽  
YoungJong Ko ◽  
JooWon Ha ◽  
...  

2021 ◽  
Vol 133 ◽  
pp. 111057
Author(s):  
Chin-Shan Kuo ◽  
Cheng-Yu Yang ◽  
Chih-Kung Lin ◽  
Gu-Jiun Lin ◽  
Huey-Kang Sytwu ◽  
...  

Author(s):  
Anirudh Menon ◽  
Vishnu Priya V ◽  
Gayathri R

<p>ABSTRACT<br />Objective: This study aims at performing a preliminary phytochemical analysis to evaluate the phytochemical composition of pineapple extract and<br />its cytotoxicity potential on oral cancer cell lines.<br />Methods: Preliminary phytochemical analysis of pineapple extract was done, 3-(4, 5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide<br />assay for evaluating the cytotoxicity potential of the extract on oral cancer cell lines was performed.<br />Results: Phytoconstituents such as flavonoids, coumarins, and phenols were present in the pineapple extract. The extract also exhibited increased<br />cytotoxicity with increased concentration.<br />Conclusion: This study is conducted to see if pineapple extract is effective in treating oral cancer in a natural way instead of harmful treatments.<br />Keywords: Cytotoxicity, Pineapple extract, Anticancer drug.</p><p> </p>


PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12554 ◽  
Author(s):  
Daisuke Yamamoto ◽  
Kaori Shima ◽  
Kou Matsuo ◽  
Takashi Nishioka ◽  
Chang Yan Chen ◽  
...  

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