Palladium-Catalyzed Direct Ethynylation of C(sp3)–H Bonds in Aliphatic Carboxylic Acid Derivatives

2011 ◽  
Vol 133 (33) ◽  
pp. 12984-12986 ◽  
Author(s):  
Yusuke Ano ◽  
Mamoru Tobisu ◽  
Naoto Chatani
Keyword(s):  
Carboxylic Acid ◽  
Aliphatic Carboxylic Acid ◽  
Palladium Catalyzed

Chelation-Assisted Palladium-Catalyzed γ-Arylation of Aliphatic Carboxylic Acid Derivatives

2017 ◽  
Vol 359 (8) ◽  
pp. 1301-1307 ◽  
Author(s):  
Aniruddha Dey ◽  
Sandeep Pimparkar ◽  
Arghya Deb ◽  
Srimanta Guin ◽  
Debabrata Maiti
Keyword(s):  
Carboxylic Acid ◽  
Aliphatic Carboxylic Acid ◽  
Palladium Catalyzed

Stereospecific, Palladium-catalyzed C(sp3)–H Alkenylation and Alkynylation of a Proline Derivative Enabled by 8-Aminoquinoline as a Directing Group

2020 ◽  
Author(s):  
Aleksandra Balliu ◽  
Aaltje Roelofje Femmigje Strijker ◽  
Michael Oschmann ◽  
Monireh Pourghasemi Lati ◽  
Oscar Verho
Keyword(s):  
Carboxylic Acid ◽  
Building Blocks ◽  
Wide Range ◽  
Palladium Catalyzed ◽  
Directing Group ◽  
High Yields ◽  
Vinyl Iodides ◽  
Initial Results

<p>In this preprint, we present our initial results concerning a stereospecific Pd-catalyzed protocol for the C3 alkenylation and alkynylation of a proline derivative carrying the well utilized 8‑aminoquinoline directing group. Efficient C–H alkenylation was achieved with a wide range of vinyl iodides bearing different aliphatic, aromatic and heteroaromatic substituents, to furnish the corresponding C3 alkenylated products in good to high yields. In addition, we were able show that this protocol can also be used to install an alkynyl group into the pyrrolidine scaffold, when a TIPS-protected alkynyl bromide was used as the reaction partner. Furthermore, two different methods for the removal of the 8-aminoquinoline auxiliary are reported, which can enable access to both <i>cis</i>- and <i>trans</i>-configured carboxylic acid building blocks from the C–H alkenylation products.</p>

Aliphatic Carboxylic Acid as Hydrogen-Bond Donor for Converting CO2 and Epoxide into Cyclic Carbonate under Mild Conditions

2021 ◽  
Author(s):  
Zheng Wang ◽  
Yajun Wang ◽  
Qianjie Xie ◽  
Zhiying Fan ◽  
Yehua Shen
Keyword(s):  
Hydrogen Bond ◽  
Carboxylic Acid ◽  
Value Added ◽  
Cyclic Carbonate ◽  
Hydrogen Bond Donor ◽  
Title Reaction ◽  
Aliphatic Carboxylic Acid ◽  
Mild Conditions ◽  
Atmospheric Carbon

The coupling of CO2 and epoxide is promising way to reduce atmospheric carbon by converting it into value-added cyclic carbonate. Pursuing efficient catalysts is highly attractive for the title reaction....

scholarly journals Comparison of Three Solid Phase Materials for the Extraction of Carboxylic Acids from River Water Followed by 2D GC × GC-TOFMS Determination

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
G. O. Bosire ◽  
J. C. Ngila ◽  
H. Parshotam
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Natural Organic Matter ◽  
Solid Phase ◽  
Cooling Water ◽  
Raw Water ◽  
Aliphatic Carboxylic Acid ◽  
Hydrophobic Nature ◽  
Relationship Of

The extraction and determination of aliphatic and aromatic carboxylic acids as well as their influence on the aromaticity and molecularity relationship of natural organic matter (NOM) in water are reported in this study. Three solid phase extraction (SPE) sorbents were used and their extraction efficiencies evaluated after chromatographic determinations (using gas chromatography with a time of flight mass spectrometer (GC × GC-TOFMS) and liquid chromatography with organic carbon detector (LC-OCD)). More than 42 carboxylic acids were identified in raw water from the Vaal River, which feeds the Lethabo Power Generation Station, South Africa, with cooling water. The aromatic carboxylic acid efficiency (28%) was achieved by using Strata™X SPE while the highest aliphatic carboxylic acid efficiency (92.08%) was achieved by silica SPE. The hydrophobic nature of NOM in water depends on the nature of organic compounds in water, whether aromatic or aliphatic. The LC-OCD was used to assess the hydrophobicity levels of NOM as a function of these carboxylic acids in cooling water. The LC-OCD results showed that the aromatic nature of NOM in SPE filtered water followed the order Silica>Strata X>C-18. From the results, the hydrophobicity degree of the samples depended on the type and number of carboxylic acids that were removed by the SPE cartridges.

THE APPLICATION OF THE ARNDT–EISTERT REACTION TO THE SYNTHESIS OF FATTY ACIDS OF HIGH MOLECULAR WEIGHT

1950 ◽  
Vol 28b (9) ◽  
pp. 556-560 ◽  
Author(s):  
F. A. Vandenheuvel ◽  
P. Yates
Keyword(s):  
Fatty Acids ◽  
Molecular Weight ◽  
Carboxylic Acid ◽  
Stearic Acid ◽  
High Molecular Weight ◽  
Efficient Method ◽  
Convenient Method ◽  
Ultraviolet Absorption ◽  
Aliphatic Carboxylic Acid ◽  
Eicosanoic Acid

The Arndt–Eistert reaction offers a convenient method for the synthesis of the higher members of the aliphatic carboxylic acid series. Nonadecanoic acid, eicosanoic acid, and heneicosanoic acid have been prepared successively from stearic acid in good yields. An efficient method of purification of the synthetic products is described. The ultraviolet absorption maxima for some diazoketones derived from the higher members of the aliphatic carboxylic acid series are recorded.

BIOSYNTHESIS OF 3-HYDROXYFUNCTIONALIZED C4-C8 ALIPHATIC CARBOXYLIC ACID FROM GLUCOSE THROUGH INVERTED FATTY ACID BETA- OXIDATION PATHWAY BY RECOMBINANT ESCHERICHIA COLI STRAINS

2020 ◽  
pp. 10-11
Author(s):  
A. Skorokhodova ◽  
V. Debabov
Keyword(s):  
Escherichia Coli ◽  
Fatty Acid ◽  
Carboxylic Acid ◽  
Recombinant Escherichia Coli ◽  
Beta Oxidation ◽  
Aliphatic Carboxylic Acid ◽  
Oxidation Pathway ◽  
Fatty Acid Beta Oxidation

The feasibility of the biosynthesis from glucose of 3-hydroxyfunctionalized C4-C8 carboxylates upon the reversal of the fatty acid beta-oxidation in recombinant Escherichia coli strains has been demonstrated.

Palladium-Catalyzed Direct ortho-Alkynylation of Aromatic Carboxylic Acid Derivatives

2011 ◽  
Vol 14 (1) ◽  
pp. 354-357 ◽  
Author(s):  
Yusuke Ano ◽  
Mamoru Tobisu ◽  
Naoto Chatani
Keyword(s):  
Carboxylic Acid ◽  
Aromatic Carboxylic Acid ◽  
Palladium Catalyzed
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