Galacto-Configured Aminocyclitol Phytoceramides Are Potent in Vivo Invariant Natural Killer T Cell Stimulators

2011 ◽  
Vol 133 (31) ◽  
pp. 12079-12084 ◽  
Author(s):  
Youssef Harrak ◽  
Carolina M. Barra ◽  
Antonio Delgado ◽  
A. Raúl Castaño ◽  
Amadeu Llebaria
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Natural Killer T Cell ◽  
Invariant Natural Killer ◽  
Killer T Cell ◽  
Natural Killer T

scholarly journals Embryonic macrophages function during early life to determine invariant natural killer T cell levels at barrier surfaces

2021 ◽  
Vol 22 (6) ◽  
pp. 699-710 ◽  
Author(s):  
Thomas Gensollen ◽  
Xi Lin ◽  
Ting Zhang ◽  
Michal Pyzik ◽  
Peter See ◽  
...  
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Early Life ◽  
Natural Killer T Cell ◽  
Invariant Natural Killer ◽  
Killer T Cell ◽  
Natural Killer T

scholarly journals Stages versus subsets: Invariant Natural Killer T cell lineage differentiation

Cytokine ◽  
2015 ◽  
Vol 72 (2) ◽  
pp. 204-209 ◽  
Author(s):  
Heather M. Buechel ◽  
Martin H. Stradner ◽  
Louise M. D’Cruz
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Cell Lineage ◽  
Natural Killer T Cell ◽  
Lineage Differentiation ◽  
Invariant Natural Killer ◽  
Killer T Cell ◽  
Natural Killer T

scholarly journals A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo

2014 ◽  
Vol 5 (4) ◽  
pp. 1437-1441 ◽  
Author(s):  
S. Deng ◽  
L. Bai ◽  
R. Reboulet ◽  
R. Matthew ◽  
D. A. Engler ◽  
...  
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Antibody Responses ◽  
Natural Killer T Cell ◽  
Cell Antigen ◽  
Killer T Cell ◽  
Natural Killer T

Vaccination of mice with liposomes containing an oligosaccharide and a natural killer T cell agonist results in generation of high titers of antibodies (IgM and IgG) for the oligosaccharide.

scholarly journals β-galactosylceramide alters invariant natural killer T cell function and is effective treatment for lupus

2009 ◽  
Vol 132 (3) ◽  
pp. 321-333 ◽  
Author(s):  
Sufi R. Morshed ◽  
Tsuyoshi Takahashi ◽  
Paul B. Savage ◽  
Neeraja Kambham ◽  
Samuel Strober
Keyword(s):  
T Cell ◽  
Effective Treatment ◽  
Natural Killer ◽  
Cell Function ◽  
Natural Killer T Cell ◽  
T Cell Function ◽  
Invariant Natural Killer ◽  
Killer T Cell ◽  
Natural Killer T

scholarly journals CircADARB1 serves as a new biomarker in natural killer T-cell lymphoma and a potential regulator of p-Stat3

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mei Mei ◽  
Yingjun Wang ◽  
Wenting Song ◽  
Zhaoming Li ◽  
Qilong Wang ◽  
...  
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Natural Killer T Cell ◽  
Potential Biomarker ◽  
Killer T Cell ◽  
Natural Killer T

Abstract Background Natural killer/T-cell lymphoma (NKTCL) is a rare and aggressive subtype of Non-Hodgkin’s Lymphoma. CircRNA has shown great potential to become a biomarker in plasma. In this study, we aimed to determine circRNA for its diagnostic and prognostic value and biological function in NKTCL. Method The circRNA microarray of plasma from NKTCL patients and healthy donors were conducted. The relative expressions of target circRNA were verified by qRT-PCR. We conducted function experiments in vitro and in vivo. Bioinformatics predicted the target miRNA of the target circRNA and the binding site was detected by the dual luciferase report assay. Downstream target protein was predicted and detected by western blot in vitro and immunohistochemistry in vivo. Result By analyzing the plasma circRNA microarrays in NKTCL, 6137 circRNAs were up-regulated and 6190 circRNAs were down-regulated. The relative expressions of circADARB1 were significantly higher in NKTCL patients. The knockdown of circADARB1 inhibited proliferation of NKTCL cells in vitro and in vivo. CircADARB1 could bind to miR-214-3p in the downstream and regulate the expression of p-Stat3. In nude mice tumor tissue, p-Stat3 was under-expressed in the circADARB1 knockdown group. Conclusion CircADARB1 was highly expressed in NKTCL plasma and circADARB1 was a potential biomarker to assist diagnosis and predict the response in NKTCL. CircADARB1 bound up to miR-214-3p and regulated p-Stat3.

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