Spore-Terminated Cantilevers for Chemical Patterning on Complex Architectures

2011 ◽  
Vol 133 (25) ◽  
pp. 9627-9629 ◽  
Author(s):  
Marcus A. Kramer ◽  
Richard L. Gieseck ◽  
Benjamin Andrews ◽  
Albena Ivanisevic
Keyword(s):  
Chemical Patterning ◽  
Complex Architectures

Chemically Fueled Assembly of Macrocycles Comprising Multiple Transient Bonds

2019 ◽  
Author(s):  
Mohammad Mosharraf Hossain ◽  
Joshua Atkinson ◽  
Scott Hartley
Keyword(s):  
Covalent Bond ◽  
Dicarboxylic Acids ◽  
Molecular Assembly ◽  
Chemical Systems ◽  
Complex Architectures ◽  
The Creation ◽  
Dynamic Exchange

Dissipative (nonequilibrium) assembly powered by chemical fuels has great potential for the creation of new adaptive chemical systems. However, while molecular assembly at equilibrium is routinely used to prepare complex architectures from polyfunctional monomers, species formed out of equilibrium have, to this point, been structurally very simple. In most examples the fuel simply effects the formation of a single transient covalent bond. Here, we show that chemical fuels can assemble bifunctional components into macrocycles containing multiple transient bonds. Specifically, dicarboxylic acids give aqueous dianhydride macrocycles on treatment with a carbodiimide. The macrocycle is assembled efficiently as a consequence of both fuel-dependent and -independent mechanisms: it undergoes slower decomposition, building up as the fuel recycles the components, and is a favored product of the dynamic exchange of the anhydride bonds. These results create new possibilities for generating structurally sophisticated out-of-equilibrium species.

Chemically Fueled Assembly of Macrocycles Comprising Multiple Transient Bonds

2019 ◽  
Author(s):  
Mohammad Mosharraf Hossain ◽  
Joshua Atkinson ◽  
Scott Hartley
Keyword(s):  
Covalent Bond ◽  
Dicarboxylic Acids ◽  
Molecular Assembly ◽  
Chemical Systems ◽  
Complex Architectures ◽  
The Creation ◽  
Dynamic Exchange

Dissipative (nonequilibrium) assembly powered by chemical fuels has great potential for the creation of new adaptive chemical systems. However, while molecular assembly at equilibrium is routinely used to prepare complex architectures from polyfunctional monomers, species formed out of equilibrium have, to this point, been structurally very simple. In most examples the fuel simply effects the formation of a single transient covalent bond. Here, we show that chemical fuels can assemble bifunctional components into macrocycles containing multiple transient bonds. Specifically, dicarboxylic acids give aqueous dianhydride macrocycles on treatment with a carbodiimide. The macrocycle is assembled efficiently as a consequence of both fuel-dependent and -independent mechanisms: it undergoes slower decomposition, building up as the fuel recycles the components, and is a favored product of the dynamic exchange of the anhydride bonds. These results create new possibilities for generating structurally sophisticated out-of-equilibrium species.

Combining Conventional Lithography with Molecular Self-Assembly for Chemical Patterning

2006 ◽  
Vol 18 (24) ◽  
pp. 3258-3260 ◽  
Author(s):  
M. E. Anderson ◽  
C. Srinivasan ◽  
J. N. Hohman ◽  
E. M. Carter ◽  
M. W. Horn ◽  
...  
Keyword(s):  
Self Assembly ◽  
Chemical Patterning

Digital documentation of complex architectures by integration of multiple techniques: the case study of Valer Castle

2007 ◽  
Author(s):  
Francesca Voltolini ◽  
Sabry El-Hakim ◽  
Fabio Remondino ◽  
Stefano Girardi ◽  
Alessandro Rizzi ◽  
...  
Keyword(s):  
Complex Architectures ◽  
Digital Documentation

Directed adenine functionalization for creating complex architectures for material and biological applications

2017 ◽  
Vol 53 (35) ◽  
pp. 4748-4758 ◽  
Author(s):  
Balaram Mohapatra ◽  
Pratibha Pratibha ◽  
Sandeep Verma
Keyword(s):  
Metal Complexes ◽  
Coordination Polymers ◽  
Gas Adsorption ◽  
Bioactive Molecules ◽  
Biological Applications ◽  
Design Strategies ◽  
Feature Article ◽  
Complex Architectures ◽  
Adenine Derivatives

This feature article outlines design strategies for modified adenine derivatives to construct discrete metal complexes, ring-expanded skeletons, coordination polymers, MOFs, and capped nanoparticles, for applications in gas adsorption, as bioimaging agents and as bioactive molecules.

Roles of temperature, solvent, M/L ratios and anion in preparing complexes containing a Himta ligand

CrystEngComm ◽  
2016 ◽  
Vol 18 (8) ◽  
pp. 1350-1362 ◽  
Author(s):  
Tiantian Yu ◽  
Shimin Wang ◽  
Xuemin Li ◽  
Xiaoli Gao ◽  
Chunlin Zhou ◽  
...  
Keyword(s):  
Influence Factors ◽  
Comprehensive Investigation ◽  
Complex Architectures

Nine new complexes based on the Himta ligand were hydrothermally synthesized and structurally characterized. A systematic and comprehensive investigation of four influence factors on some complex architectures was carried out.

Chemical patterning of sub-50-nm half pitches via nanoimprint lithography

2005 ◽  
Vol 78-79 ◽  
pp. 682-688 ◽  
Author(s):  
Sunggook Park ◽  
Sina Saxer ◽  
Celestino Padeste ◽  
Harun H. Solak ◽  
Jens Gobrecht ◽  
...  
Keyword(s):  
Nanoimprint Lithography ◽  
Chemical Patterning

Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs

1996 ◽  
Vol 109 (2) ◽  
pp. 367-377 ◽  
Author(s):  
H. Dutartre ◽  
J. Davoust ◽  
J.P. Gorvel ◽  
P. Chavrier
Keyword(s):  
Actin Cytoskeleton ◽  
Rho Gtpases ◽  
Mammalian Cells ◽  
Laser Scanning ◽  
Rho Gtpase ◽  
Laser Scanning Microscopy ◽  
Regulatory Subunit ◽  
Confocal Laser ◽  
Complex Architectures ◽  
Immunofluorescence Labelling

In mammalian cells, Rho GTPases control the reorganisation of the actin cytoskeleton in response to growth factors. In the cytoplasm, the polymerisation of actin filaments and their organisation into complex architectures is orchestrated by numerous proteins which act either directly, by interacting with actin, or by producing secondary messengers which serve as mediators between signal transduction pathways and the microfilament organisation. We sought to determine whether the intracellular distribution of some of these regulatory components may be controlled by the Rho GTPase CDC42Hs. With this aim, we have established HeLa-derived human cell lines in which expression of a constitutively activated mutant of CDC42Hs is inducible. Morphological analysis by immunofluorescence labelling and confocal laser scanning microscopy revealed a massive reorganisation of F-actin in cortical microspikes as well as podosome-like structures located at the ventral face of the cells. Concomitantly, the cells became giant and multinucleate indicating that cytokinesis was impaired. The actin bundling protein T-plastin, the vasodilatator-stimulated phosphoprotein (VASP), a profilin ligand, as well as the 85 kDa regulatory subunit of the phosphoinosite 3-kinase redistributed with F-actin into the CDC42Hs-induced structures.

How cells tell up from down and stick together to construct multicellular tissues – interplay between apicobasal polarity and cell–cell adhesion

2021 ◽  
Vol 134 (21) ◽  
Author(s):  
Claudia G. Vasquez ◽  
Eva L. de la Serna ◽  
Alexander R. Dunn
Keyword(s):  
Cell Adhesion ◽  
Protein Complexes ◽  
Basic Function ◽  
Cell Junction ◽  
Evolutionary Innovation ◽  
Apicobasal Polarity ◽  
Complex Architectures ◽  
Main Components ◽  
Definition Of ◽  
Cell Cell

ABSTRACT Polarized epithelia define a topological inside and outside, and hence constitute a key evolutionary innovation that enabled the construction of complex multicellular animal life. Over time, this basic function has been elaborated upon to yield the complex architectures of many of the organs that make up the human body. The two processes necessary to yield a polarized epithelium, namely regulated adhesion between cells and the definition of the apicobasal (top–bottom) axis, have likewise undergone extensive evolutionary elaboration, resulting in multiple sophisticated protein complexes that contribute to both functions. Understanding how these components function in combination to yield the basic architecture of a polarized cell–cell junction remains a major challenge. In this Review, we introduce the main components of apicobasal polarity and cell–cell adhesion complexes, and outline what is known about their regulation and assembly in epithelia. In addition, we highlight studies that investigate the interdependence between these two networks. We conclude with an overview of strategies to address the largest and arguably most fundamental unresolved question in the field, namely how a polarized junction arises as the sum of its molecular parts.

scholarly journals Methodology for the Assessment of Imprecise Multi-State System Availability

Mathematics ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 150
Author(s):  
Joanna Akrouche ◽  
Mohamed Sallak ◽  
Eric Châtelet ◽  
Fahed Abdallah ◽  
Hiba Hajj Chehade
Keyword(s):  
Markov Chains ◽  
Constraint Propagation ◽  
State System ◽  
Combined Approach ◽  
System Availability ◽  
Contraction Method ◽  
Numerical Examples ◽  
Complex Architectures ◽  
Backward Propagation ◽  
Interval Constraint

Most existing studies of a system’s availability in the presence of epistemic uncertainties assume that the system is binary. In this paper, a new methodology for the estimation of the availability of multi-state systems is developed, taking into consideration epistemic uncertainties. This paper formulates a combined approach, based on continuous Markov chains and interval contraction methods, to address the problem of computing the availability of multi-state systems with imprecise failure and repair rates. The interval constraint propagation method, which we refer to as the forward–backward propagation (FBP) contraction method, allows us to contract the probability intervals, keeping all the values that may be consistent with the set of constraints. This methodology is guaranteed, and several numerical examples of systems with complex architectures are studied.

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