Solid-Phase Synthesis, Thermal Denaturation Studies, Nuclease Resistance, and Cellular Uptake of (Oligodeoxyribonucleoside)methylborane Phosphine–DNA Chimeras

2011 ◽  
Vol 133 (25) ◽  
pp. 9844-9854 ◽  
Author(s):  
Heera Krishna ◽  
Marvin H. Caruthers
Keyword(s):  
Cellular Uptake ◽  
Thermal Denaturation ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Nuclease Resistance

Solid-phase synthesis and thermal denaturation study of cyclic PNAs targeting the HIV-1 TAR RNA loop

2007 ◽  
Vol 17 (21) ◽  
pp. 6026-6030 ◽  
Author(s):  
Gregory Upert ◽  
Mohamed Mehiri ◽  
Audrey Di Giorgio ◽  
Roger Condom ◽  
Nadia Patino
Keyword(s):  
Thermal Denaturation ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Thermal Denaturation Study ◽  
Tar Rna ◽  
Hiv 1

Synthesis of Asparagusic Acid Modified Lysine and its Application in Solid-Phase Synthesis of Peptides with Enhanced Cellular Uptake

Synlett ◽  
2017 ◽  
Vol 29 (10) ◽  
pp. 1289-1292 ◽  
Author(s):  
Pablo Rivera-Fuentes ◽  
Alina Tirla ◽  
Moritz Hansen
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Cellular Uptake ◽  
Building Block ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Live Cells ◽  
Phase Synthesis ◽  
Scalable Synthesis

Cyclic disulfides, such as asparagusic acid, enhance the uptake of a variety of cargoes into live cells. Here, we report a robust and scalable synthesis of an asparagusic acid modified lysine. This amino acid can be used in solid-phase peptide synthesis. We confirmed that incorporation of this building block into the sequence of a peptide increases its cellular uptake substantially.

Concise solid-phase synthesis enables derivatisation of YEATS domain cyclopeptide inhibitors for improved cellular uptake

2021 ◽  
pp. 116342
Author(s):  
Yixiang Jiang ◽  
Sha Liu ◽  
Gaofei Tian ◽  
Hayden Jit Hei Cheung ◽  
Xin Li ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis
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