scholarly journals Temperature Dependence of the Kinetic Isotope Effects in Thymidylate Synthase. A Theoretical Study

2011 ◽  
Vol 133 (17) ◽  
pp. 6692-6702 ◽  
Author(s):  
Natalia Kanaan ◽  
Silvia Ferrer ◽  
Sergio Martí ◽  
Mireia Garcia-Viloca ◽  
Amnon Kohen ◽  
...  
Keyword(s):  
Temperature Dependence ◽  
Thymidylate Synthase ◽  
Theoretical Study ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope

DEUTERIUM KINETIC ISOTOPE EFFECTS: V TEMPERATURE DEPENDENCE OF β-DEUTERIUM EFFECTS IN WATER SOLVOLYSIS OF ISOPROPYL COMPOUNDS

1961 ◽  
Vol 39 (10) ◽  
pp. 1989-1994 ◽  
Author(s):  
K. T. Leffek ◽  
R. E. Robertson ◽  
S. E. Sugamori
Keyword(s):  
Temperature Dependence ◽  
Isotope Effect ◽  
Isotope Effects ◽  
Zero Point ◽  
Kinetic Isotope Effects ◽  
Methyl Groups ◽  
Deuterium Isotope Effect ◽  
Point Energy ◽  
Kinetic Isotope ◽  
Enthalpy Of Activation

The secondary β-deuterium isotope effect (kH/kD) has been measured over a range of temperature for the water solvolysis reactions of isopropyl methanesulphonate, p-toluenesulphonate, and bromide. In these cases the isotope effect is due to a difference in entropies of activation of the isotopic analogues rather than a difference in the enthalpies of activation. It is suggested that the observed isotope effect is due to internal rotational effects of the methyl groups in the isopropyl radical, and the lack of an isotope effect on the enthalpy of activation is accounted for by a cancellation of an effect from this source and one from zero-point energy.

Sign in / Sign up

Export Citation Format

Share Document