Synthesis of Streptolydigin, a Potent Bacterial RNA Polymerase Inhibitor

2010 ◽  
Vol 132 (41) ◽  
pp. 14394-14396 ◽  
Author(s):  
Sergey V. Pronin ◽  
Sergey A. Kozmin
Keyword(s):  
Rna Polymerase ◽  
Bacterial Rna ◽  
Polymerase Inhibitor

scholarly journals Ribosomal RNA degradation induced by the bacterial RNA polymerase inhibitor rifampicin.

RNA ◽  
2021 ◽  
pp. rna.078776.121
Author(s):  
Lina Hamouche ◽  
Leonora Poljak ◽  
Agamemnon J. Carpousis
Keyword(s):  
Rna Polymerase ◽  
Ribosomal Rna ◽  
Rna Degradation ◽  
Bacterial Rna ◽  
Polymerase Inhibitor

scholarly journals New Insights into the Bacterial RNA Polymerase Inhibitor CBR703 as a Starting Point for Optimization as an Anti-Infective Agent

2014 ◽  
Vol 58 (7) ◽  
pp. 4242-4245 ◽  
Author(s):  
Weixing Zhu ◽  
Jörg Haupenthal ◽  
Matthias Groh ◽  
Michelle Fountain ◽  
Rolf W. Hartmann
Keyword(s):  
Rna Polymerase ◽  
Biofilm Formation ◽  
Mammalian Cells ◽  
Antibacterial Agents ◽  
Antibacterial Activities ◽  
Bacterial Rna ◽  
Starting Point ◽  
Polymerase Inhibitor ◽  
Derivatives Of ◽  
Infective Agent

ABSTRACTCBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents.

Total Synthesis of the Bacterial RNA Polymerase Inhibitor Ripostatin B

2012 ◽  
Vol 124 (14) ◽  
pp. 3461-3465 ◽  
Author(s):  
Florian Glaus ◽  
Karl-Heinz Altmann
Keyword(s):  
Rna Polymerase ◽  
Total Synthesis ◽  
Bacterial Rna ◽  
Polymerase Inhibitor
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