Conformational Control of Thymine Photodimerization in Single-Strand and Duplex DNA Containing Locked Nucleic Acid TT Steps

2010 ◽  
Vol 132 (37) ◽  
pp. 12856-12858 ◽  
Author(s):  
Mahesh Hariharan ◽  
Martin McCullagh ◽  
George C. Schatz ◽  
Frederick D. Lewis
Keyword(s):  
Nucleic Acid ◽  
Single Strand ◽  
Locked Nucleic Acid ◽  
Duplex Dna ◽  
Conformational Control

scholarly journals Conformational Control of Thymine Photodimerization in Single-Strand and Duplex DNA Containing Locked Nucleic Acid TT Steps

2010 ◽  
Vol 132 (44) ◽  
pp. 15831-15831 ◽  
Author(s):  
Mahesh Hariharan ◽  
Martin McCullagh ◽  
George C. Schatz ◽  
Frederick D. Lewis
Keyword(s):  
Nucleic Acid ◽  
Single Strand ◽  
Locked Nucleic Acid ◽  
Duplex Dna ◽  
Conformational Control

scholarly journals Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA

2013 ◽  
Vol 41 (5) ◽  
pp. 3257-3273 ◽  
Author(s):  
Pedro M. D. Moreno ◽  
Sylvain Geny ◽  
Y. Vladimir Pabon ◽  
Helen Bergquist ◽  
Eman M. Zaghloul ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Duplex Dna

Structures of Artificially Designed RNA Nanoarchitectures at Near-Atomic Resolution

2020 ◽  
Author(s):  
Di Liu ◽  
Yaming Shao ◽  
Joseph A. Piccirilli ◽  
Yossi Weizmann
Keyword(s):  
Nucleic Acid ◽  
High Resolution ◽  
Single Strand ◽  
Atomic Resolution ◽  
Rna Motifs ◽  
X Ray ◽  
Structural Details ◽  
Rna Motif

<p>Though advances in nanotechnology have enabled the construction of synthetic nucleic acid based nanoarchitectures with ever-increasing complexity for various applications, high-resolution structures are lacking due to the difficulty of obtaining good diffracting crystals. Here we report the design of RNA nanostructures based on homooligomerizable tiles from an RNA single-strand for X-ray determination. Three structures are solved to near-atomic resolution: a 2D parallelogram, an unexpectedly formed 3D nanobracelet, and a 3D nanocage. Structural details of their constituent motifs—such as kissing loops, branched kissing-loops and T-junctions—that resemble natural RNA motifs and resisted X-ray determination are revealed. This work unveils the largely unexplored potential of crystallography in gaining high-resolution feedback for nanostructure design and suggests a novel route to investigate RNA motif structures by configuring them into nanoarchitectures.</p>

Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications

2021 ◽  
Author(s):  
Annamalai Senthilvelan ◽  
Tyson Vonderfecht ◽  
Muthian Shanmugasundaram ◽  
Indra Pal ◽  
Jason Potter ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Acid Moiety ◽  
Therapeutic Applications

Solution Structure of a Locked Nucleic Acid Modified Quadruplex: Introducing the V4 Folding Topology

2009 ◽  
Vol 121 (17) ◽  
pp. 3145-3149 ◽  
Author(s):  
Jakob T. Nielsen ◽  
Khalil Arar ◽  
Michael Petersen
Keyword(s):  
Nucleic Acid ◽  
Solution Structure ◽  
Locked Nucleic Acid

i-Motif Formation with Locked Nucleic Acid (LNA)

2007 ◽  
Vol 119 (48) ◽  
pp. 9380-9382 ◽  
Author(s):  
Niti Kumar ◽  
Jakob T. Nielsen ◽  
Souvik Maiti ◽  
Michael Petersen
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid

A Locked Nucleic Acid-Based Nanocrawler: Designed and Reversible Movement Detected by Multicolor Fluorescence

2013 ◽  
Vol 135 (7) ◽  
pp. 2423-2426 ◽  
Author(s):  
I. Kira Astakhova ◽  
Karol Pasternak ◽  
Meghan A. Campbell ◽  
Pankaj Gupta ◽  
Jesper Wengel
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Multicolor Fluorescence
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